Determination of potency and paraspecific effects of Androctonus crassicauda (Olivier, 1807) antivenom against Mesobuthus gibbosus (Brullé, 1832) venom (Scorpiones: Buthidae)
Scorpion envenomation remains a real health problem in many countries. In scorpionism cases, it is often recommended that patients be treated with species-specific antivenom. Androctonus crassicauda venom has been used as antigen for antivenom production in Turkey, where this antivenom, called Turki...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:0ecd4b384a184a3bb3b29507c5f9af4d 2023-05-15T15:05:26+02:00 Determination of potency and paraspecific effects of Androctonus crassicauda (Olivier, 1807) antivenom against Mesobuthus gibbosus (Brullé, 1832) venom (Scorpiones: Buthidae) O. Ozkan S. Adiguzel S. Kar S. Yakistiran Y. Cesaretli K. Z. Karaer 2007-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992007000200008 https://doaj.org/article/0ecd4b384a184a3bb3b29507c5f9af4d EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000200008 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992007000200008 1678-9199 https://doaj.org/article/0ecd4b384a184a3bb3b29507c5f9af4d Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 2, Pp 500-508 (2007) scorpion antivenom Androctonus crassicauda Mesobuthus gibbosus paraspecific activity Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2007 ftdoajarticles https://doi.org/10.1590/S1678-91992007000200008 2022-12-31T15:01:02Z Scorpion envenomation remains a real health problem in many countries. In scorpionism cases, it is often recommended that patients be treated with species-specific antivenom. Androctonus crassicauda venom has been used as antigen for antivenom production in Turkey, where this antivenom, called Turkish antivenom, has also been effective in the treatment of envenomation caused by species other than A. crassicauda. The present study aimed at determining the paraspecific effects and potency of the Turkish antivenom against Mesobuthus gibbosus (Brullé, 1832) venom. To assess the venom toxicity and the antivenom efficacy, we determined the Minimum Lethal Dose (MLD) and the Minimum Effective Dose (MED) instead of LD50 and ED50, respectively. Androctonus crassicauda antivenom was capable of neutralizing M. gibbosus venom (20 MLD). This was the first study indicating that A. crassicauda antivenom can be used for the treatment of Mesobuthus gibbosus stings, especially in Aegean Region, Turkey. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 13 2 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
scorpion antivenom Androctonus crassicauda Mesobuthus gibbosus paraspecific activity Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
scorpion antivenom Androctonus crassicauda Mesobuthus gibbosus paraspecific activity Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 O. Ozkan S. Adiguzel S. Kar S. Yakistiran Y. Cesaretli K. Z. Karaer Determination of potency and paraspecific effects of Androctonus crassicauda (Olivier, 1807) antivenom against Mesobuthus gibbosus (Brullé, 1832) venom (Scorpiones: Buthidae) |
topic_facet |
scorpion antivenom Androctonus crassicauda Mesobuthus gibbosus paraspecific activity Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Scorpion envenomation remains a real health problem in many countries. In scorpionism cases, it is often recommended that patients be treated with species-specific antivenom. Androctonus crassicauda venom has been used as antigen for antivenom production in Turkey, where this antivenom, called Turkish antivenom, has also been effective in the treatment of envenomation caused by species other than A. crassicauda. The present study aimed at determining the paraspecific effects and potency of the Turkish antivenom against Mesobuthus gibbosus (Brullé, 1832) venom. To assess the venom toxicity and the antivenom efficacy, we determined the Minimum Lethal Dose (MLD) and the Minimum Effective Dose (MED) instead of LD50 and ED50, respectively. Androctonus crassicauda antivenom was capable of neutralizing M. gibbosus venom (20 MLD). This was the first study indicating that A. crassicauda antivenom can be used for the treatment of Mesobuthus gibbosus stings, especially in Aegean Region, Turkey. |
format |
Article in Journal/Newspaper |
author |
O. Ozkan S. Adiguzel S. Kar S. Yakistiran Y. Cesaretli K. Z. Karaer |
author_facet |
O. Ozkan S. Adiguzel S. Kar S. Yakistiran Y. Cesaretli K. Z. Karaer |
author_sort |
O. Ozkan |
title |
Determination of potency and paraspecific effects of Androctonus crassicauda (Olivier, 1807) antivenom against Mesobuthus gibbosus (Brullé, 1832) venom (Scorpiones: Buthidae) |
title_short |
Determination of potency and paraspecific effects of Androctonus crassicauda (Olivier, 1807) antivenom against Mesobuthus gibbosus (Brullé, 1832) venom (Scorpiones: Buthidae) |
title_full |
Determination of potency and paraspecific effects of Androctonus crassicauda (Olivier, 1807) antivenom against Mesobuthus gibbosus (Brullé, 1832) venom (Scorpiones: Buthidae) |
title_fullStr |
Determination of potency and paraspecific effects of Androctonus crassicauda (Olivier, 1807) antivenom against Mesobuthus gibbosus (Brullé, 1832) venom (Scorpiones: Buthidae) |
title_full_unstemmed |
Determination of potency and paraspecific effects of Androctonus crassicauda (Olivier, 1807) antivenom against Mesobuthus gibbosus (Brullé, 1832) venom (Scorpiones: Buthidae) |
title_sort |
determination of potency and paraspecific effects of androctonus crassicauda (olivier, 1807) antivenom against mesobuthus gibbosus (brullé, 1832) venom (scorpiones: buthidae) |
publisher |
SciELO |
publishDate |
2007 |
url |
https://doi.org/10.1590/S1678-91992007000200008 https://doaj.org/article/0ecd4b384a184a3bb3b29507c5f9af4d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 2, Pp 500-508 (2007) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000200008 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992007000200008 1678-9199 https://doaj.org/article/0ecd4b384a184a3bb3b29507c5f9af4d |
op_doi |
https://doi.org/10.1590/S1678-91992007000200008 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
13 |
container_issue |
2 |
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1766337141799911424 |