Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents
A phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT...
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ftdoajarticles:oai:doaj.org/article:0e82546d8ca942eb964536ff494589af 2024-09-09T19:25:20+00:00 Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents Geraldo Célio Brandão Erna G. Kroon José D. Souza Filho Alaíde Braga Oliveira 2017-01-01T00:00:00Z https://doi.org/10.1155/2017/6106959 https://doaj.org/article/0e82546d8ca942eb964536ff494589af EN eng Wiley http://dx.doi.org/10.1155/2017/6106959 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2017/6106959 https://doaj.org/article/0e82546d8ca942eb964536ff494589af Journal of Tropical Medicine, Vol 2017 (2017) Arctic medicine. Tropical medicine RC955-962 article 2017 ftdoajarticles https://doi.org/10.1155/2017/6106959 2024-08-05T17:48:37Z A phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT method. All the ethanol extracts were active against DENV-2, HSV-1, and VACV-WR with best results for the fruits extract against DENV-2 (SI > 38.2). For VACV-WR and HSV-1, EC50 values > 200 μg mL−1 were determined, while no inhibition of the cytopathic effect was observed with EMCV. Five compounds were isolated and identified as the C-glucosylxanthones mangiferin (1), 2′-O-trans-caffeoylmangiferin (2), 2′-O-trans-coumaroylmangiferin (3), 2′-O-trans-cinnamoylmangiferin (5), and the flavonoid chrysin (4). The most active compound was 2′-O-trans-coumaroylmangiferin (3) with SI > 121.9 against DENV-2 and 108.7 for HSV-1. These results indicate that mangiferin cinnamoyl esters might be potential antiviral drugs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2017 1 11 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Geraldo Célio Brandão Erna G. Kroon José D. Souza Filho Alaíde Braga Oliveira Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
A phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT method. All the ethanol extracts were active against DENV-2, HSV-1, and VACV-WR with best results for the fruits extract against DENV-2 (SI > 38.2). For VACV-WR and HSV-1, EC50 values > 200 μg mL−1 were determined, while no inhibition of the cytopathic effect was observed with EMCV. Five compounds were isolated and identified as the C-glucosylxanthones mangiferin (1), 2′-O-trans-caffeoylmangiferin (2), 2′-O-trans-coumaroylmangiferin (3), 2′-O-trans-cinnamoylmangiferin (5), and the flavonoid chrysin (4). The most active compound was 2′-O-trans-coumaroylmangiferin (3) with SI > 121.9 against DENV-2 and 108.7 for HSV-1. These results indicate that mangiferin cinnamoyl esters might be potential antiviral drugs. |
format |
Article in Journal/Newspaper |
author |
Geraldo Célio Brandão Erna G. Kroon José D. Souza Filho Alaíde Braga Oliveira |
author_facet |
Geraldo Célio Brandão Erna G. Kroon José D. Souza Filho Alaíde Braga Oliveira |
author_sort |
Geraldo Célio Brandão |
title |
Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents |
title_short |
Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents |
title_full |
Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents |
title_fullStr |
Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents |
title_full_unstemmed |
Antiviral Activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents |
title_sort |
antiviral activity of fridericia formosa (bureau) l. g. lohmann (bignoniaceae) extracts and constituents |
publisher |
Wiley |
publishDate |
2017 |
url |
https://doi.org/10.1155/2017/6106959 https://doaj.org/article/0e82546d8ca942eb964536ff494589af |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2017 (2017) |
op_relation |
http://dx.doi.org/10.1155/2017/6106959 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2017/6106959 https://doaj.org/article/0e82546d8ca942eb964536ff494589af |
op_doi |
https://doi.org/10.1155/2017/6106959 |
container_title |
Journal of Tropical Medicine |
container_volume |
2017 |
container_start_page |
1 |
op_container_end_page |
11 |
_version_ |
1809895073485160448 |