Ventricular arrhythmias in Chagas disease
Sudden death is one of the most characteristic phenomena of Chagas disease, and approximately one-third of infected patients develop life-threatening heart disease, including malignant ventricular arrhythmias. Fibrotic lesions secondary to chronic cardiomyopathy produce arrhythmogenic substrates tha...
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ftdoajarticles:oai:doaj.org/article:0e24567fbc984a92a69ebf742fd983e7 2023-05-15T15:09:55+02:00 Ventricular arrhythmias in Chagas disease Marco Paulo Tomaz Barbosa Andre Assis Lopes do Carmo Manoel Otávio da Costa Rocha Antonio Luiz Pinho Ribeiro 2015-02-01T00:00:00Z https://doi.org/10.1590/0037-8682-0003-2014 https://doaj.org/article/0e24567fbc984a92a69ebf742fd983e7 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000100004&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0003-2014 https://doaj.org/article/0e24567fbc984a92a69ebf742fd983e7 Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 1, Pp 4-10 (2015) Chagas disease Arrhythmia Sudden death Pacemaker Implantable cardioverter Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.1590/0037-8682-0003-2014 2022-12-30T21:38:59Z Sudden death is one of the most characteristic phenomena of Chagas disease, and approximately one-third of infected patients develop life-threatening heart disease, including malignant ventricular arrhythmias. Fibrotic lesions secondary to chronic cardiomyopathy produce arrhythmogenic substrates that lead to the appearance and maintenance of ventricular arrhythmias. The objective of this study is to discuss the main clinical and epidemiological aspects of ventricular arrhythmias in Chagas disease, the specific workups and treatments for these abnormalities, and the breakthroughs needed to determine a more effective approach to these arrhythmias. A literature review was performed via a search of the PubMed database from 1965 to May 31, 2014 for studies of patients with Chagas disease. Clinical management of patients with chronic Chagas disease begins with proper clinical stratification and the identification of individuals at a higher risk of sudden cardiac death. Once a patient develops malignant ventricular arrhythmia, the therapeutic approach aims to prevent the recurrence of arrhythmias and sudden cardiac death by the use of implantable cardioverter defibrillators, antiarrhythmic drugs, or both. In select cases, invasive ablation of the reentrant circuit causing tachycardia may be useful. Ventricular arrhythmias are important manifestations of Chagas cardiomyopathy. This review highlights the absence of high-quality evidence regarding the treatment of ventricular arrhythmias in Chagas disease. Recognizing high-risk patients who require specific therapies, especially invasive procedures such as the implantation of cardioverter defibrillators and ablative approaches, is a major challenge in clinical practice. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 48 1 4 10 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Chagas disease Arrhythmia Sudden death Pacemaker Implantable cardioverter Arctic medicine. Tropical medicine RC955-962 |
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Chagas disease Arrhythmia Sudden death Pacemaker Implantable cardioverter Arctic medicine. Tropical medicine RC955-962 Marco Paulo Tomaz Barbosa Andre Assis Lopes do Carmo Manoel Otávio da Costa Rocha Antonio Luiz Pinho Ribeiro Ventricular arrhythmias in Chagas disease |
topic_facet |
Chagas disease Arrhythmia Sudden death Pacemaker Implantable cardioverter Arctic medicine. Tropical medicine RC955-962 |
description |
Sudden death is one of the most characteristic phenomena of Chagas disease, and approximately one-third of infected patients develop life-threatening heart disease, including malignant ventricular arrhythmias. Fibrotic lesions secondary to chronic cardiomyopathy produce arrhythmogenic substrates that lead to the appearance and maintenance of ventricular arrhythmias. The objective of this study is to discuss the main clinical and epidemiological aspects of ventricular arrhythmias in Chagas disease, the specific workups and treatments for these abnormalities, and the breakthroughs needed to determine a more effective approach to these arrhythmias. A literature review was performed via a search of the PubMed database from 1965 to May 31, 2014 for studies of patients with Chagas disease. Clinical management of patients with chronic Chagas disease begins with proper clinical stratification and the identification of individuals at a higher risk of sudden cardiac death. Once a patient develops malignant ventricular arrhythmia, the therapeutic approach aims to prevent the recurrence of arrhythmias and sudden cardiac death by the use of implantable cardioverter defibrillators, antiarrhythmic drugs, or both. In select cases, invasive ablation of the reentrant circuit causing tachycardia may be useful. Ventricular arrhythmias are important manifestations of Chagas cardiomyopathy. This review highlights the absence of high-quality evidence regarding the treatment of ventricular arrhythmias in Chagas disease. Recognizing high-risk patients who require specific therapies, especially invasive procedures such as the implantation of cardioverter defibrillators and ablative approaches, is a major challenge in clinical practice. |
format |
Article in Journal/Newspaper |
author |
Marco Paulo Tomaz Barbosa Andre Assis Lopes do Carmo Manoel Otávio da Costa Rocha Antonio Luiz Pinho Ribeiro |
author_facet |
Marco Paulo Tomaz Barbosa Andre Assis Lopes do Carmo Manoel Otávio da Costa Rocha Antonio Luiz Pinho Ribeiro |
author_sort |
Marco Paulo Tomaz Barbosa |
title |
Ventricular arrhythmias in Chagas disease |
title_short |
Ventricular arrhythmias in Chagas disease |
title_full |
Ventricular arrhythmias in Chagas disease |
title_fullStr |
Ventricular arrhythmias in Chagas disease |
title_full_unstemmed |
Ventricular arrhythmias in Chagas disease |
title_sort |
ventricular arrhythmias in chagas disease |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2015 |
url |
https://doi.org/10.1590/0037-8682-0003-2014 https://doaj.org/article/0e24567fbc984a92a69ebf742fd983e7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 1, Pp 4-10 (2015) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000100004&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0003-2014 https://doaj.org/article/0e24567fbc984a92a69ebf742fd983e7 |
op_doi |
https://doi.org/10.1590/0037-8682-0003-2014 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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48 |
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