Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea
Abstract Background The protection afforded by human erythrocyte polymorphisms against the malaria parasite, Plasmodium falciparum , has been proposed to be due to reduced ability of the parasite to invade or develop in erythrocytes. If this were the case, variable levels of parasitaemia and rates o...
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ftdoajarticles:oai:doaj.org/article:0e1ed02db87645f1a5f789a87e285c2f 2023-05-15T15:07:19+02:00 Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea Imrie Heather J Tavul Livingstone Ripley Ruth M Pilling Lynn Michon Pascal Fowkes Freya JI Woods Caira M Mgone Charles S Luty Adrian JF Day Karen P 2008-01-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-1 https://doaj.org/article/0e1ed02db87645f1a5f789a87e285c2f EN eng BMC http://www.malariajournal.com/content/7/1/1 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-1 1475-2875 https://doaj.org/article/0e1ed02db87645f1a5f789a87e285c2f Malaria Journal, Vol 7, Iss 1, p 1 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-1 2022-12-31T01:41:19Z Abstract Background The protection afforded by human erythrocyte polymorphisms against the malaria parasite, Plasmodium falciparum , has been proposed to be due to reduced ability of the parasite to invade or develop in erythrocytes. If this were the case, variable levels of parasitaemia and rates of seroconversion to infected-erythrocyte variant surface antigens (VSA) should be seen in different host genotypes. Methods To test this hypothesis, P. falciparum parasitaemia and anti-VSA antibody levels were measured in a cohort of 555 asymptomatic children from an area of intense malaria transmission in Papua New Guinea. Linear mixed models were used to investigate the effect of α + -thalassaemia, complement receptor-1 and south-east Asian ovalocytosis, as well as glucose-6-phosphate dehydrogenase deficiency and ABO blood group on parasitaemia and age-specific seroconversion to VSA. Results No host polymorphism showed a significant association with both parasite prevalence/density and age-specific seroconversion to VSA. Conclusion Host erythrocyte polymorphisms commonly found in Papua New Guinea do not effect exposure to blood stage P. falciparum infection. This contrasts with data for sickle cell trait and highlights that the above-mentioned polymorphisms may confer protection against malaria via distinct mechanisms. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Sickle ENVELOPE(-66.783,-66.783,-68.867,-68.867) Malaria Journal 7 1 1 |
institution |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Imrie Heather J Tavul Livingstone Ripley Ruth M Pilling Lynn Michon Pascal Fowkes Freya JI Woods Caira M Mgone Charles S Luty Adrian JF Day Karen P Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The protection afforded by human erythrocyte polymorphisms against the malaria parasite, Plasmodium falciparum , has been proposed to be due to reduced ability of the parasite to invade or develop in erythrocytes. If this were the case, variable levels of parasitaemia and rates of seroconversion to infected-erythrocyte variant surface antigens (VSA) should be seen in different host genotypes. Methods To test this hypothesis, P. falciparum parasitaemia and anti-VSA antibody levels were measured in a cohort of 555 asymptomatic children from an area of intense malaria transmission in Papua New Guinea. Linear mixed models were used to investigate the effect of α + -thalassaemia, complement receptor-1 and south-east Asian ovalocytosis, as well as glucose-6-phosphate dehydrogenase deficiency and ABO blood group on parasitaemia and age-specific seroconversion to VSA. Results No host polymorphism showed a significant association with both parasite prevalence/density and age-specific seroconversion to VSA. Conclusion Host erythrocyte polymorphisms commonly found in Papua New Guinea do not effect exposure to blood stage P. falciparum infection. This contrasts with data for sickle cell trait and highlights that the above-mentioned polymorphisms may confer protection against malaria via distinct mechanisms. |
format |
Article in Journal/Newspaper |
author |
Imrie Heather J Tavul Livingstone Ripley Ruth M Pilling Lynn Michon Pascal Fowkes Freya JI Woods Caira M Mgone Charles S Luty Adrian JF Day Karen P |
author_facet |
Imrie Heather J Tavul Livingstone Ripley Ruth M Pilling Lynn Michon Pascal Fowkes Freya JI Woods Caira M Mgone Charles S Luty Adrian JF Day Karen P |
author_sort |
Imrie Heather J |
title |
Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea |
title_short |
Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea |
title_full |
Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea |
title_fullStr |
Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea |
title_full_unstemmed |
Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea |
title_sort |
host erythrocyte polymorphisms and exposure to plasmodium falciparum in papua new guinea |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-1 https://doaj.org/article/0e1ed02db87645f1a5f789a87e285c2f |
long_lat |
ENVELOPE(-66.783,-66.783,-68.867,-68.867) |
geographic |
Arctic Sickle |
geographic_facet |
Arctic Sickle |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 1 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/1 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-1 1475-2875 https://doaj.org/article/0e1ed02db87645f1a5f789a87e285c2f |
op_doi |
https://doi.org/10.1186/1475-2875-7-1 |
container_title |
Malaria Journal |
container_volume |
7 |
container_issue |
1 |
container_start_page |
1 |
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1766338845923606528 |