Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria
Abstract Background It has been previously demonstrated that a single nucleotide polymorphism (SNP) in the IL13 promoter region, IL13 -1055T>C (rs1800925), was associated with susceptibility to severe malaria in Thais. In the present study, fine association mapping for a cytokine gene cluster inc...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2009
|
Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-8-232 https://doaj.org/article/0dfb40684bb4423f9fa69a4ed1e8e0cc |
id |
ftdoajarticles:oai:doaj.org/article:0dfb40684bb4423f9fa69a4ed1e8e0cc |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:0dfb40684bb4423f9fa69a4ed1e8e0cc 2023-05-15T15:07:38+02:00 Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria Tsuchiya Naoyuki Hananantachai Hathairad Tokunaga Katsushi Nuchnoi Pornlada Patarapotikul Jintana Nishida Nao Naka Izumi Ohashi Jun 2009-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-8-232 https://doaj.org/article/0dfb40684bb4423f9fa69a4ed1e8e0cc EN eng BMC http://www.malariajournal.com/content/8/1/232 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-232 1475-2875 https://doaj.org/article/0dfb40684bb4423f9fa69a4ed1e8e0cc Malaria Journal, Vol 8, Iss 1, p 232 (2009) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1186/1475-2875-8-232 2022-12-31T08:50:59Z Abstract Background It has been previously demonstrated that a single nucleotide polymorphism (SNP) in the IL13 promoter region, IL13 -1055T>C (rs1800925), was associated with susceptibility to severe malaria in Thais. In the present study, fine association mapping for a cytokine gene cluster including IL4 , IL5 , and IL13 on chromosome 5q31 was conducted using the same malaria subjects to refine the region containing a primary variant or a haplotype susceptible to severe malaria. Methods A total of 82 SNPs spanning 522 kb of the 5q31 region were analysed in 368 patients with Plasmodium falciparum malaria (203 mild malaria and 165 severe malaria patients). Results Only rs1881457 located in the promoter region of IL13 , which is in linkage disequilibrium with rs1800925 (r 2 = 0.73), showed a significant association with severe malaria after adjusting for multiple testing (P = 0.046 by permutation test). This SNP was in a haplotype block spanning 97 kb (from rs2069812 to rs2240032). The detected haplotype block contained the RAD50 gene and the promoter of IL13 , but not the other genes. Conclusion A haplotype block in which a primary polymorphism associated with severe malaria is likely to be encoded was identified in Thai malaria patients. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 8 1 232 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Tsuchiya Naoyuki Hananantachai Hathairad Tokunaga Katsushi Nuchnoi Pornlada Patarapotikul Jintana Nishida Nao Naka Izumi Ohashi Jun Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background It has been previously demonstrated that a single nucleotide polymorphism (SNP) in the IL13 promoter region, IL13 -1055T>C (rs1800925), was associated with susceptibility to severe malaria in Thais. In the present study, fine association mapping for a cytokine gene cluster including IL4 , IL5 , and IL13 on chromosome 5q31 was conducted using the same malaria subjects to refine the region containing a primary variant or a haplotype susceptible to severe malaria. Methods A total of 82 SNPs spanning 522 kb of the 5q31 region were analysed in 368 patients with Plasmodium falciparum malaria (203 mild malaria and 165 severe malaria patients). Results Only rs1881457 located in the promoter region of IL13 , which is in linkage disequilibrium with rs1800925 (r 2 = 0.73), showed a significant association with severe malaria after adjusting for multiple testing (P = 0.046 by permutation test). This SNP was in a haplotype block spanning 97 kb (from rs2069812 to rs2240032). The detected haplotype block contained the RAD50 gene and the promoter of IL13 , but not the other genes. Conclusion A haplotype block in which a primary polymorphism associated with severe malaria is likely to be encoded was identified in Thai malaria patients. |
format |
Article in Journal/Newspaper |
author |
Tsuchiya Naoyuki Hananantachai Hathairad Tokunaga Katsushi Nuchnoi Pornlada Patarapotikul Jintana Nishida Nao Naka Izumi Ohashi Jun |
author_facet |
Tsuchiya Naoyuki Hananantachai Hathairad Tokunaga Katsushi Nuchnoi Pornlada Patarapotikul Jintana Nishida Nao Naka Izumi Ohashi Jun |
author_sort |
Tsuchiya Naoyuki |
title |
Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria |
title_short |
Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria |
title_full |
Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria |
title_fullStr |
Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria |
title_full_unstemmed |
Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria |
title_sort |
identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria |
publisher |
BMC |
publishDate |
2009 |
url |
https://doi.org/10.1186/1475-2875-8-232 https://doaj.org/article/0dfb40684bb4423f9fa69a4ed1e8e0cc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 8, Iss 1, p 232 (2009) |
op_relation |
http://www.malariajournal.com/content/8/1/232 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-232 1475-2875 https://doaj.org/article/0dfb40684bb4423f9fa69a4ed1e8e0cc |
op_doi |
https://doi.org/10.1186/1475-2875-8-232 |
container_title |
Malaria Journal |
container_volume |
8 |
container_issue |
1 |
container_start_page |
232 |
_version_ |
1766339096893980672 |