Lessons from the epidemiological surveillance program, during the influenza A (H1N1) virus epidemic, in a reference university hospital of Southeastern Brazil
INTRODUCTION: The case definition of influenza-like illness (ILI) is a powerful epidemiological tool during influenza epidemics. METHODS: A prospective cohort study was conducted to evaluate the impact of two definitions used as epidemiological tools, in adults and children, during the influenza A H...
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ftdoajarticles:oai:doaj.org/article:0dec63fe20824b4b9eeee7b2fddcfe3f 2023-05-15T15:11:20+02:00 Lessons from the epidemiological surveillance program, during the influenza A (H1N1) virus epidemic, in a reference university hospital of Southeastern Brazil Maria Luiza Moretti Verônica Sinkoc Luis Gustavo de Oliveira Cardoso Gema Jesus de Camargo Luis Felipe Bachur Christian Cruz Hofling Rodrigo Angerami Plínio Trabasso Márcia Teixeira Garcia Mariângela Ribeiro Resende 2011-08-01T00:00:00Z https://doi.org/10.1590/s0037-86822011005000048 https://doaj.org/article/0dec63fe20824b4b9eeee7b2fddcfe3f EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000400001&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/s0037-86822011005000048 https://doaj.org/article/0dec63fe20824b4b9eeee7b2fddcfe3f Revista da Sociedade Brasileira de Medicina Tropical, Vol 44, Iss 4, Pp 405-411 (2011) Influenza sazonal Influenza A H1N1 Vigilância epidemiológica Síndrome gripal Síndrome respiratória aguda Arctic medicine. Tropical medicine RC955-962 article 2011 ftdoajarticles https://doi.org/10.1590/s0037-86822011005000048 2022-12-30T23:22:51Z INTRODUCTION: The case definition of influenza-like illness (ILI) is a powerful epidemiological tool during influenza epidemics. METHODS: A prospective cohort study was conducted to evaluate the impact of two definitions used as epidemiological tools, in adults and children, during the influenza A H1N1 epidemic. Patients were included if they had upper respiratory samples tested for influenza by real-time reverse transcriptase polymerase chain reaction during two periods, using the ILI definition (coughing + temperature > 38ºC) in period 1, and the definition of severe acute respiratory infection (ARS) (coughing + temperature > 38ºC and dyspnoea) in period 2. RESULTS: The study included 366 adults and 147 children, covering 243 cases of ILI and 270 cases of ARS. Laboratory confirmed cases of influenza were higher in adults (50%) than in children (21.6%) ( p < 0.0001) and influenza infection was more prevalent in the ILI definition (53%) than ARS (24.4%) (p < 0.0001). Adults reported more chills and myalgia than children (p = 0.0001). Oseltamivir was administered in 58% and 46% of adults and children with influenza A H1N1, respectively. The influenza A H1N1 case fatality rate was 7% in adults and 8.3% in children. The mean time from onset of illness until antiviral administration was 4 days. CONCLUSIONS: The modification of ILI to ARS definition resulted in less accuracy in influenza diagnosis and did not improve the appropriate time and use of antiviral medication. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Aguda ENVELOPE(-26.750,-26.750,-76.150,-76.150) Revista da Sociedade Brasileira de Medicina Tropical 44 4 405 411 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Influenza sazonal Influenza A H1N1 Vigilância epidemiológica Síndrome gripal Síndrome respiratória aguda Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Influenza sazonal Influenza A H1N1 Vigilância epidemiológica Síndrome gripal Síndrome respiratória aguda Arctic medicine. Tropical medicine RC955-962 Maria Luiza Moretti Verônica Sinkoc Luis Gustavo de Oliveira Cardoso Gema Jesus de Camargo Luis Felipe Bachur Christian Cruz Hofling Rodrigo Angerami Plínio Trabasso Márcia Teixeira Garcia Mariângela Ribeiro Resende Lessons from the epidemiological surveillance program, during the influenza A (H1N1) virus epidemic, in a reference university hospital of Southeastern Brazil |
topic_facet |
Influenza sazonal Influenza A H1N1 Vigilância epidemiológica Síndrome gripal Síndrome respiratória aguda Arctic medicine. Tropical medicine RC955-962 |
description |
INTRODUCTION: The case definition of influenza-like illness (ILI) is a powerful epidemiological tool during influenza epidemics. METHODS: A prospective cohort study was conducted to evaluate the impact of two definitions used as epidemiological tools, in adults and children, during the influenza A H1N1 epidemic. Patients were included if they had upper respiratory samples tested for influenza by real-time reverse transcriptase polymerase chain reaction during two periods, using the ILI definition (coughing + temperature > 38ºC) in period 1, and the definition of severe acute respiratory infection (ARS) (coughing + temperature > 38ºC and dyspnoea) in period 2. RESULTS: The study included 366 adults and 147 children, covering 243 cases of ILI and 270 cases of ARS. Laboratory confirmed cases of influenza were higher in adults (50%) than in children (21.6%) ( p < 0.0001) and influenza infection was more prevalent in the ILI definition (53%) than ARS (24.4%) (p < 0.0001). Adults reported more chills and myalgia than children (p = 0.0001). Oseltamivir was administered in 58% and 46% of adults and children with influenza A H1N1, respectively. The influenza A H1N1 case fatality rate was 7% in adults and 8.3% in children. The mean time from onset of illness until antiviral administration was 4 days. CONCLUSIONS: The modification of ILI to ARS definition resulted in less accuracy in influenza diagnosis and did not improve the appropriate time and use of antiviral medication. |
format |
Article in Journal/Newspaper |
author |
Maria Luiza Moretti Verônica Sinkoc Luis Gustavo de Oliveira Cardoso Gema Jesus de Camargo Luis Felipe Bachur Christian Cruz Hofling Rodrigo Angerami Plínio Trabasso Márcia Teixeira Garcia Mariângela Ribeiro Resende |
author_facet |
Maria Luiza Moretti Verônica Sinkoc Luis Gustavo de Oliveira Cardoso Gema Jesus de Camargo Luis Felipe Bachur Christian Cruz Hofling Rodrigo Angerami Plínio Trabasso Márcia Teixeira Garcia Mariângela Ribeiro Resende |
author_sort |
Maria Luiza Moretti |
title |
Lessons from the epidemiological surveillance program, during the influenza A (H1N1) virus epidemic, in a reference university hospital of Southeastern Brazil |
title_short |
Lessons from the epidemiological surveillance program, during the influenza A (H1N1) virus epidemic, in a reference university hospital of Southeastern Brazil |
title_full |
Lessons from the epidemiological surveillance program, during the influenza A (H1N1) virus epidemic, in a reference university hospital of Southeastern Brazil |
title_fullStr |
Lessons from the epidemiological surveillance program, during the influenza A (H1N1) virus epidemic, in a reference university hospital of Southeastern Brazil |
title_full_unstemmed |
Lessons from the epidemiological surveillance program, during the influenza A (H1N1) virus epidemic, in a reference university hospital of Southeastern Brazil |
title_sort |
lessons from the epidemiological surveillance program, during the influenza a (h1n1) virus epidemic, in a reference university hospital of southeastern brazil |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2011 |
url |
https://doi.org/10.1590/s0037-86822011005000048 https://doaj.org/article/0dec63fe20824b4b9eeee7b2fddcfe3f |
long_lat |
ENVELOPE(-26.750,-26.750,-76.150,-76.150) |
geographic |
Arctic Aguda |
geographic_facet |
Arctic Aguda |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 44, Iss 4, Pp 405-411 (2011) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000400001&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/s0037-86822011005000048 https://doaj.org/article/0dec63fe20824b4b9eeee7b2fddcfe3f |
op_doi |
https://doi.org/10.1590/s0037-86822011005000048 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
44 |
container_issue |
4 |
container_start_page |
405 |
op_container_end_page |
411 |
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