The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children
Abstract Background Antibodies targeting malaria blood-stage antigens are important targets of naturally acquired immunity, and may act as valuable biomarkers of malaria exposure. Methods Six-hundred and one young Malawian children from a randomized trial of prenatal nutrient supplementation with ir...
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ftdoajarticles:oai:doaj.org/article:0d8130bc7f1f42c39adf6cabba87ee8f 2023-05-15T15:16:49+02:00 The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children Priyanka Barua James G. Beeson Kenneth Maleta Per Ashorn Stephen J. Rogerson 2019-01-01T00:00:00Z https://doi.org/10.1186/s12936-019-2647-8 https://doaj.org/article/0d8130bc7f1f42c39adf6cabba87ee8f EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2647-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2647-8 1475-2875 https://doaj.org/article/0d8130bc7f1f42c39adf6cabba87ee8f Malaria Journal, Vol 18, Iss 1, Pp 1-12 (2019) Episodes Nutrient supplements Randomized controlled trial Merozoite antigens Variant surface antigens Seroprevalence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2647-8 2022-12-31T03:21:02Z Abstract Background Antibodies targeting malaria blood-stage antigens are important targets of naturally acquired immunity, and may act as valuable biomarkers of malaria exposure. Methods Six-hundred and one young Malawian children from a randomized trial of prenatal nutrient supplementation with iron and folic acid or pre- and postnatal multiple micronutrients or lipid-based nutrient supplements were followed up weekly at home and febrile episodes were investigated for malaria from birth to 18 months of age. Antibodies were measured for 601 children against merozoite surface proteins (MSP1 19kD, MSP2), erythrocyte binding antigen 175 (EBA175), reticulocyte binding protein homologue 2 (Rh2A9), schizont extract and variant surface antigens expressed by Plasmodium falciparum-infected erythrocytes (IE) at 18 months of age. The antibody measurement data was related to concurrent malaria infection and to documented episodes of clinical malaria. Results At 18 months of age, antibodies were significantly higher among parasitaemic than aparasitaemic children. Antibody levels against MSP1 19kD, MSP2, schizont extract, and IE variant surface antigens were significantly higher in children who had documented episodes of malaria than in children who did not. Antibody levels did not differ between children with single or multiple malaria episodes before 18 months, nor between children who had malaria before 6 months of age or between 6 and 18 months. Conclusions Antibodies to merozoite and IE surface antigens increased following infection in early childhood, but neither age at first infection nor number of malaria episodes substantially affected antibody acquisition. These findings have implications for malaria surveillance during early childhood in the context of elimination. Trials registration Clinical Trials Registration: NCT01239693 (Date of registration: 11-10-2010). URL: http://www.ilins.org Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Episodes Nutrient supplements Randomized controlled trial Merozoite antigens Variant surface antigens Seroprevalence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Episodes Nutrient supplements Randomized controlled trial Merozoite antigens Variant surface antigens Seroprevalence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Priyanka Barua James G. Beeson Kenneth Maleta Per Ashorn Stephen J. Rogerson The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children |
topic_facet |
Episodes Nutrient supplements Randomized controlled trial Merozoite antigens Variant surface antigens Seroprevalence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Antibodies targeting malaria blood-stage antigens are important targets of naturally acquired immunity, and may act as valuable biomarkers of malaria exposure. Methods Six-hundred and one young Malawian children from a randomized trial of prenatal nutrient supplementation with iron and folic acid or pre- and postnatal multiple micronutrients or lipid-based nutrient supplements were followed up weekly at home and febrile episodes were investigated for malaria from birth to 18 months of age. Antibodies were measured for 601 children against merozoite surface proteins (MSP1 19kD, MSP2), erythrocyte binding antigen 175 (EBA175), reticulocyte binding protein homologue 2 (Rh2A9), schizont extract and variant surface antigens expressed by Plasmodium falciparum-infected erythrocytes (IE) at 18 months of age. The antibody measurement data was related to concurrent malaria infection and to documented episodes of clinical malaria. Results At 18 months of age, antibodies were significantly higher among parasitaemic than aparasitaemic children. Antibody levels against MSP1 19kD, MSP2, schizont extract, and IE variant surface antigens were significantly higher in children who had documented episodes of malaria than in children who did not. Antibody levels did not differ between children with single or multiple malaria episodes before 18 months, nor between children who had malaria before 6 months of age or between 6 and 18 months. Conclusions Antibodies to merozoite and IE surface antigens increased following infection in early childhood, but neither age at first infection nor number of malaria episodes substantially affected antibody acquisition. These findings have implications for malaria surveillance during early childhood in the context of elimination. Trials registration Clinical Trials Registration: NCT01239693 (Date of registration: 11-10-2010). URL: http://www.ilins.org |
format |
Article in Journal/Newspaper |
author |
Priyanka Barua James G. Beeson Kenneth Maleta Per Ashorn Stephen J. Rogerson |
author_facet |
Priyanka Barua James G. Beeson Kenneth Maleta Per Ashorn Stephen J. Rogerson |
author_sort |
Priyanka Barua |
title |
The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children |
title_short |
The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children |
title_full |
The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children |
title_fullStr |
The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children |
title_full_unstemmed |
The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children |
title_sort |
impact of early life exposure to plasmodium falciparum on the development of naturally acquired immunity to malaria in young malawian children |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2647-8 https://doaj.org/article/0d8130bc7f1f42c39adf6cabba87ee8f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-12 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2647-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2647-8 1475-2875 https://doaj.org/article/0d8130bc7f1f42c39adf6cabba87ee8f |
op_doi |
https://doi.org/10.1186/s12936-019-2647-8 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766347106137669632 |