Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy
Abstract Coronavirus disease 2019 (COVID-19) is a rapid-spread infectious disease caused by the SARS-CoV-2 virus, which can culminate in the renin-angiotensin-aldosterone (RAAS) and kallikrein-kinin (KKS) systems imbalance, and in serious consequences for infected patients. This scoping review of pu...
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ftdoajarticles:oai:doaj.org/article:0d76f4e85807462691fea2140804a326 2023-05-15T15:06:35+02:00 Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy Lilian Caroline Gonçalves Oliveira Nayara Azinheira Nobrega Cruz Bruna Ricelli Helio Tedesco-Silva Jr José Osmar Medina-Pestana Dulce Elena Casarini 2021-12-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-2020-0181 https://doaj.org/article/0d76f4e85807462691fea2140804a326 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992021000100218&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2020-0181 https://doaj.org/article/0d76f4e85807462691fea2140804a326 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 27 (2021) Renin-angiotensin-aldosterone system Kallikrein-kinin system COVID-19 SARS-associated coronavirus Inflammation Coronavirus Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2021 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2020-0181 2022-12-30T20:21:15Z Abstract Coronavirus disease 2019 (COVID-19) is a rapid-spread infectious disease caused by the SARS-CoV-2 virus, which can culminate in the renin-angiotensin-aldosterone (RAAS) and kallikrein-kinin (KKS) systems imbalance, and in serious consequences for infected patients. This scoping review of published research exploring the RAAS and KKS was undertaken in order to trace the history of the discovery of both systems and their multiple interactions, discuss some aspects of the viral-cell interaction, including inflammation and the system imbalance triggered by SARS-CoV-2 infection, and their consequent disorders. Furthermore, we correlate the effects of continued use of the RAAS blockers in chronic diseases therapies with the virulence and physiopathology of COVID-19. We also approach the RAAS and KKS-related proposed potential therapies for treatment of COVID-19. In this way, we reinforce the importance of exploring both systems and the application of their components or their blockers in the treatment of coronavirus disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 27 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Renin-angiotensin-aldosterone system Kallikrein-kinin system COVID-19 SARS-associated coronavirus Inflammation Coronavirus Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Renin-angiotensin-aldosterone system Kallikrein-kinin system COVID-19 SARS-associated coronavirus Inflammation Coronavirus Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Lilian Caroline Gonçalves Oliveira Nayara Azinheira Nobrega Cruz Bruna Ricelli Helio Tedesco-Silva Jr José Osmar Medina-Pestana Dulce Elena Casarini Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy |
topic_facet |
Renin-angiotensin-aldosterone system Kallikrein-kinin system COVID-19 SARS-associated coronavirus Inflammation Coronavirus Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Coronavirus disease 2019 (COVID-19) is a rapid-spread infectious disease caused by the SARS-CoV-2 virus, which can culminate in the renin-angiotensin-aldosterone (RAAS) and kallikrein-kinin (KKS) systems imbalance, and in serious consequences for infected patients. This scoping review of published research exploring the RAAS and KKS was undertaken in order to trace the history of the discovery of both systems and their multiple interactions, discuss some aspects of the viral-cell interaction, including inflammation and the system imbalance triggered by SARS-CoV-2 infection, and their consequent disorders. Furthermore, we correlate the effects of continued use of the RAAS blockers in chronic diseases therapies with the virulence and physiopathology of COVID-19. We also approach the RAAS and KKS-related proposed potential therapies for treatment of COVID-19. In this way, we reinforce the importance of exploring both systems and the application of their components or their blockers in the treatment of coronavirus disease. |
format |
Article in Journal/Newspaper |
author |
Lilian Caroline Gonçalves Oliveira Nayara Azinheira Nobrega Cruz Bruna Ricelli Helio Tedesco-Silva Jr José Osmar Medina-Pestana Dulce Elena Casarini |
author_facet |
Lilian Caroline Gonçalves Oliveira Nayara Azinheira Nobrega Cruz Bruna Ricelli Helio Tedesco-Silva Jr José Osmar Medina-Pestana Dulce Elena Casarini |
author_sort |
Lilian Caroline Gonçalves Oliveira |
title |
Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy |
title_short |
Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy |
title_full |
Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy |
title_fullStr |
Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy |
title_full_unstemmed |
Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy |
title_sort |
interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for covid-19 therapy |
publisher |
SciELO |
publishDate |
2021 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2020-0181 https://doaj.org/article/0d76f4e85807462691fea2140804a326 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 27 (2021) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992021000100218&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2020-0181 https://doaj.org/article/0d76f4e85807462691fea2140804a326 |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2020-0181 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
27 |
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