Cogan’s sign in a patient with suspected post-COVID-19 vaccine-associated myasthenia gravis

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: José Wagner Leonel Tavares-Júnior, Manoel Alves Sobreira-Neto, Pedro Braga-Neto
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2023
• Subjects: COVID-19; SARS-CoV-2 Infection; Myasthenia Gravis; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0007-2023; https://doaj.org/article/0d42b6a76b974b9eb179776011a83ef4

ABSTRACT The Cogan’s sign is indicative of myasthenia gravis. This is the first report of neurological signs in a patient with post-COVID-19 vaccine-associated myasthenia gravis in Brazil. In this case, a previously healthy 68-year-old woman presented with proximal limb weakness, left ptosis, and diplopia 1 month after receiving her fourth dose of the COVID-19 vaccine. Neurological examination revealed the presence of Cogan’s sign, and she recovered rapidly after treatment. To our knowledge, this is the first reported case of myasthenia gravis associated with the COVID-19 vaccine in Brazil.