Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis
Abstract INTRODUCTION: The drugs currently available for leishmaniasis treatment have major limitations. METHODS: In vitro and in vivo studies were performed to evaluate the effect of a quinoline derivative, Hydraqui (7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline, against Leishmania amazonensis...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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Online Access: | https://doi.org/10.1590/0037-8682-0091-2020 https://doaj.org/article/0cebde6fbc5e482b895241131e3fe7a8 |
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ftdoajarticles:oai:doaj.org/article:0cebde6fbc5e482b895241131e3fe7a8 2023-05-15T15:01:27+02:00 Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis Luciana Maria Ribeiro Antinarelli Marcus Vinicius Nora de Souza Eduardo Antonio Ferraz Coelho Wallace Pacienza Lima Elaine Soares Coimbra 2020-06-01T00:00:00Z https://doi.org/10.1590/0037-8682-0091-2020 https://doaj.org/article/0cebde6fbc5e482b895241131e3fe7a8 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100653&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0091-2020 https://doaj.org/article/0cebde6fbc5e482b895241131e3fe7a8 Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020) Leishmania amazonensis Quinoline Chemotherapy Cutaneous leishmaniasis Toxicity Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.1590/0037-8682-0091-2020 2022-12-31T02:52:37Z Abstract INTRODUCTION: The drugs currently available for leishmaniasis treatment have major limitations. METHODS: In vitro and in vivo studies were performed to evaluate the effect of a quinoline derivative, Hydraqui (7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline, against Leishmania amazonensis. In silico analyses of absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters were performed. RESULTS: Hydraqui showed significant in vitro anti-amastigote activity. Also, Hydraqui-treated mice exhibited high efficacy in lesion size (48.3%) and parasitic load (93.8%) reduction, did not cause hepatic and renal toxicity, and showed appropriate ADMET properties. CONCLUSIONS: Hydraqui presents a set of satisfactory criteria for its application as an antileishmanial agent. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 53 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Leishmania amazonensis Quinoline Chemotherapy Cutaneous leishmaniasis Toxicity Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Leishmania amazonensis Quinoline Chemotherapy Cutaneous leishmaniasis Toxicity Arctic medicine. Tropical medicine RC955-962 Luciana Maria Ribeiro Antinarelli Marcus Vinicius Nora de Souza Eduardo Antonio Ferraz Coelho Wallace Pacienza Lima Elaine Soares Coimbra Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis |
topic_facet |
Leishmania amazonensis Quinoline Chemotherapy Cutaneous leishmaniasis Toxicity Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: The drugs currently available for leishmaniasis treatment have major limitations. METHODS: In vitro and in vivo studies were performed to evaluate the effect of a quinoline derivative, Hydraqui (7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline, against Leishmania amazonensis. In silico analyses of absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters were performed. RESULTS: Hydraqui showed significant in vitro anti-amastigote activity. Also, Hydraqui-treated mice exhibited high efficacy in lesion size (48.3%) and parasitic load (93.8%) reduction, did not cause hepatic and renal toxicity, and showed appropriate ADMET properties. CONCLUSIONS: Hydraqui presents a set of satisfactory criteria for its application as an antileishmanial agent. |
format |
Article in Journal/Newspaper |
author |
Luciana Maria Ribeiro Antinarelli Marcus Vinicius Nora de Souza Eduardo Antonio Ferraz Coelho Wallace Pacienza Lima Elaine Soares Coimbra |
author_facet |
Luciana Maria Ribeiro Antinarelli Marcus Vinicius Nora de Souza Eduardo Antonio Ferraz Coelho Wallace Pacienza Lima Elaine Soares Coimbra |
author_sort |
Luciana Maria Ribeiro Antinarelli |
title |
Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis |
title_short |
Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis |
title_full |
Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis |
title_fullStr |
Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis |
title_full_unstemmed |
Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis |
title_sort |
efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by leishmania amazonensis |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2020 |
url |
https://doi.org/10.1590/0037-8682-0091-2020 https://doaj.org/article/0cebde6fbc5e482b895241131e3fe7a8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100653&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0091-2020 https://doaj.org/article/0cebde6fbc5e482b895241131e3fe7a8 |
op_doi |
https://doi.org/10.1590/0037-8682-0091-2020 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
53 |
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