Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau.
Human T-Lymphotropic Virus Type 1 (HTLV-1) infection causes lethal adult T-cell leukemia (ATL) and severely debilitating HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in up to 5% of infected adults. HTLV-1 is endemic in parts of Africa and the highest prevalence in West Africa (5...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0001690 https://doaj.org/article/0c321f8188db4b78ade42757c267336c |
id |
ftdoajarticles:oai:doaj.org/article:0c321f8188db4b78ade42757c267336c |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:0c321f8188db4b78ade42757c267336c 2023-05-15T15:18:16+02:00 Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau. Carla van Tienen Thushan I de Silva Luiz Carlos Junior Alcantara Clayton O Onyango Sheikh Jarju Nato Gonçalves Tim Vincent Peter Aaby Hilton Whittle Maarten Schim van der Loeff Matthew Cotten 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001690 https://doaj.org/article/0c321f8188db4b78ade42757c267336c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3373628?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001690 https://doaj.org/article/0c321f8188db4b78ade42757c267336c PLoS Neglected Tropical Diseases, Vol 6, Iss 6, p e1690 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001690 2022-12-30T21:04:29Z Human T-Lymphotropic Virus Type 1 (HTLV-1) infection causes lethal adult T-cell leukemia (ATL) and severely debilitating HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in up to 5% of infected adults. HTLV-1 is endemic in parts of Africa and the highest prevalence in West Africa (5%) has been reported in Caio, a rural area in the North-West of Guinea-Bissau. It is not known which HTLV-1 variants are present in this community. Sequence data can provide insights in the molecular epidemiology and help to understand the origin and spread of HTLV-1.To gain insight into the molecular diversity of HTLV-1 in West Africa.HTLV-1 infected individuals were identified in community surveys between 1990-2007. The complete Long Terminal Repeat (LTR) and p24 coding region of HTLV-1 was sequenced from infected subjects. Socio-demographic data were obtained from community census and from interviews performed by fieldworkers. Phylogenetic analyses were performed to characterize the relationship between the Caio HTLV-1 and HTLV-1 from other parts of the world.LTR and p24 sequences were obtained from 72 individuals (36 LTR, 24 p24 only and 12 both). Consistent with the low evolutionary change of HTLV-1, many of the sequences from unrelated individuals showed 100% nucleotide identity. Most (45 of 46) of the LTR sequences clustered with the Cosmopolitan HTLV-1 subtype 1a, subgroup D (1aD). LTR and p24 sequences from two subjects were divergent and formed a significant cluster with HTLV-1 subtype 1g, and with the most divergent African Simian T-cell Lymphotropic Virus, Tan90.The Cosmopolitan HTLV-1 1aD predominates in this rural West African community. However, HTLV-1 subtype 1g is also present. This subtype has not been described before in West Africa and may be more widespread than previously thought. These data are in line with the hypothesis that multiple monkey-to-man zoonotic events are contributing to HTLV-1 diversity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 6 e1690 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Carla van Tienen Thushan I de Silva Luiz Carlos Junior Alcantara Clayton O Onyango Sheikh Jarju Nato Gonçalves Tim Vincent Peter Aaby Hilton Whittle Maarten Schim van der Loeff Matthew Cotten Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Human T-Lymphotropic Virus Type 1 (HTLV-1) infection causes lethal adult T-cell leukemia (ATL) and severely debilitating HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in up to 5% of infected adults. HTLV-1 is endemic in parts of Africa and the highest prevalence in West Africa (5%) has been reported in Caio, a rural area in the North-West of Guinea-Bissau. It is not known which HTLV-1 variants are present in this community. Sequence data can provide insights in the molecular epidemiology and help to understand the origin and spread of HTLV-1.To gain insight into the molecular diversity of HTLV-1 in West Africa.HTLV-1 infected individuals were identified in community surveys between 1990-2007. The complete Long Terminal Repeat (LTR) and p24 coding region of HTLV-1 was sequenced from infected subjects. Socio-demographic data were obtained from community census and from interviews performed by fieldworkers. Phylogenetic analyses were performed to characterize the relationship between the Caio HTLV-1 and HTLV-1 from other parts of the world.LTR and p24 sequences were obtained from 72 individuals (36 LTR, 24 p24 only and 12 both). Consistent with the low evolutionary change of HTLV-1, many of the sequences from unrelated individuals showed 100% nucleotide identity. Most (45 of 46) of the LTR sequences clustered with the Cosmopolitan HTLV-1 subtype 1a, subgroup D (1aD). LTR and p24 sequences from two subjects were divergent and formed a significant cluster with HTLV-1 subtype 1g, and with the most divergent African Simian T-cell Lymphotropic Virus, Tan90.The Cosmopolitan HTLV-1 1aD predominates in this rural West African community. However, HTLV-1 subtype 1g is also present. This subtype has not been described before in West Africa and may be more widespread than previously thought. These data are in line with the hypothesis that multiple monkey-to-man zoonotic events are contributing to HTLV-1 diversity. |
format |
Article in Journal/Newspaper |
author |
Carla van Tienen Thushan I de Silva Luiz Carlos Junior Alcantara Clayton O Onyango Sheikh Jarju Nato Gonçalves Tim Vincent Peter Aaby Hilton Whittle Maarten Schim van der Loeff Matthew Cotten |
author_facet |
Carla van Tienen Thushan I de Silva Luiz Carlos Junior Alcantara Clayton O Onyango Sheikh Jarju Nato Gonçalves Tim Vincent Peter Aaby Hilton Whittle Maarten Schim van der Loeff Matthew Cotten |
author_sort |
Carla van Tienen |
title |
Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau. |
title_short |
Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau. |
title_full |
Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau. |
title_fullStr |
Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau. |
title_full_unstemmed |
Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau. |
title_sort |
molecular epidemiology of endemic human t-lymphotropic virus type 1 in a rural community in guinea-bissau. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001690 https://doaj.org/article/0c321f8188db4b78ade42757c267336c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 6, p e1690 (2012) |
op_relation |
http://europepmc.org/articles/PMC3373628?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001690 https://doaj.org/article/0c321f8188db4b78ade42757c267336c |
op_doi |
https://doi.org/10.1371/journal.pntd.0001690 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
6 |
container_issue |
6 |
container_start_page |
e1690 |
_version_ |
1766348468944633856 |