Can the performance of pyrethroid-chlorfenapyr nets be reduced when combined with pyrethroid-piperonyl butoxide (PBO) nets?
Abstract Background Pyrethroid-chlorfenapyr (CFP) and pyrethroid-piperonyl butoxide (PBO) nets are being scaled across endemic countries to improve control of malaria transmitted by pyrethroid-resistant mosquitoes. CFP is a pro-insecticide requiring activation by mosquito cytochrome P450 monooxygena...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2023
|
Subjects: | |
Online Access: | https://doi.org/10.1186/s12936-023-04648-6 https://doaj.org/article/0bb61af54cee4454aacc6372dc356a11 |
id |
ftdoajarticles:oai:doaj.org/article:0bb61af54cee4454aacc6372dc356a11 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:0bb61af54cee4454aacc6372dc356a11 2023-08-20T04:05:03+02:00 Can the performance of pyrethroid-chlorfenapyr nets be reduced when combined with pyrethroid-piperonyl butoxide (PBO) nets? Thomas Syme Judicaël Nounagnon Boris N’dombidjé Martial Gbegbo Abel Agbevo Juniace Ahoga Corine Ngufor 2023-07-01T00:00:00Z https://doi.org/10.1186/s12936-023-04648-6 https://doaj.org/article/0bb61af54cee4454aacc6372dc356a11 EN eng BMC https://doi.org/10.1186/s12936-023-04648-6 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04648-6 1475-2875 https://doaj.org/article/0bb61af54cee4454aacc6372dc356a11 Malaria Journal, Vol 22, Iss 1, Pp 1-16 (2023) Insecticide-treated nets Chlorfenapyr Piperonyl butoxide Pyrethroid Vector control Anopheles gambiae Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-023-04648-6 2023-07-30T00:40:07Z Abstract Background Pyrethroid-chlorfenapyr (CFP) and pyrethroid-piperonyl butoxide (PBO) nets are being scaled across endemic countries to improve control of malaria transmitted by pyrethroid-resistant mosquitoes. CFP is a pro-insecticide requiring activation by mosquito cytochrome P450 monooxygenase enzymes (P450s) while PBO improves pyrethroid potency by inhibiting the action of these enzymes in pyrethroid-resistant mosquitoes. The inhibitory action of PBO against P450s may thus reduce the efficacy of pyrethroid-CFP nets when applied inside the same household as pyrethroid-PBO nets. Methods Two experimental hut trials were performed to evaluate the entomological impact of two different types of pyrethroid-CFP ITN (Interceptor® G2, PermaNet® Dual) when applied alone and in combination with pyrethroid-PBO ITNs (DuraNet® Plus, PermaNet® 3.0) against a pyrethroid-resistant vector population in southern Benin. In both trials, all net types were tested as single and double net treatments. Bioassays were also performed to assess the resistance profile of the vector population at the hut site and investigate interactions between CFP and PBO. Results The vector population was susceptible to CFP but exhibited a high intensity of pyrethroid resistance that was overcame by PBO pre-exposure. Vector mortality was significantly lower in huts with combinations of pyrethroid-CFP nets plus pyrethroid-PBO nets compared to huts with two pyrethroid-CFP nets (74% vs. 85% for Interceptor® G2 and 57% vs. 83% for PermaNet® Dual, p < 0.001). PBO pre-exposure reduced the toxicity of CFP in bottle bioassays suggesting this effect may be partly attributable to antagonism between CFP and PBO. Higher levels of vector mortality were observed in huts with net combinations that included pyrethroid-CFP nets compared to those that did not and highest mortality was achieved when pyrethroid-CFP nets were applied alone as two nets together (83–85%). Conclusions This study shows evidence of a reduced performance of pyrethroid-CFP nets when ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 22 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Insecticide-treated nets Chlorfenapyr Piperonyl butoxide Pyrethroid Vector control Anopheles gambiae Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Insecticide-treated nets Chlorfenapyr Piperonyl butoxide Pyrethroid Vector control Anopheles gambiae Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Thomas Syme Judicaël Nounagnon Boris N’dombidjé Martial Gbegbo Abel Agbevo Juniace Ahoga Corine Ngufor Can the performance of pyrethroid-chlorfenapyr nets be reduced when combined with pyrethroid-piperonyl butoxide (PBO) nets? |
topic_facet |
Insecticide-treated nets Chlorfenapyr Piperonyl butoxide Pyrethroid Vector control Anopheles gambiae Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Pyrethroid-chlorfenapyr (CFP) and pyrethroid-piperonyl butoxide (PBO) nets are being scaled across endemic countries to improve control of malaria transmitted by pyrethroid-resistant mosquitoes. CFP is a pro-insecticide requiring activation by mosquito cytochrome P450 monooxygenase enzymes (P450s) while PBO improves pyrethroid potency by inhibiting the action of these enzymes in pyrethroid-resistant mosquitoes. The inhibitory action of PBO against P450s may thus reduce the efficacy of pyrethroid-CFP nets when applied inside the same household as pyrethroid-PBO nets. Methods Two experimental hut trials were performed to evaluate the entomological impact of two different types of pyrethroid-CFP ITN (Interceptor® G2, PermaNet® Dual) when applied alone and in combination with pyrethroid-PBO ITNs (DuraNet® Plus, PermaNet® 3.0) against a pyrethroid-resistant vector population in southern Benin. In both trials, all net types were tested as single and double net treatments. Bioassays were also performed to assess the resistance profile of the vector population at the hut site and investigate interactions between CFP and PBO. Results The vector population was susceptible to CFP but exhibited a high intensity of pyrethroid resistance that was overcame by PBO pre-exposure. Vector mortality was significantly lower in huts with combinations of pyrethroid-CFP nets plus pyrethroid-PBO nets compared to huts with two pyrethroid-CFP nets (74% vs. 85% for Interceptor® G2 and 57% vs. 83% for PermaNet® Dual, p < 0.001). PBO pre-exposure reduced the toxicity of CFP in bottle bioassays suggesting this effect may be partly attributable to antagonism between CFP and PBO. Higher levels of vector mortality were observed in huts with net combinations that included pyrethroid-CFP nets compared to those that did not and highest mortality was achieved when pyrethroid-CFP nets were applied alone as two nets together (83–85%). Conclusions This study shows evidence of a reduced performance of pyrethroid-CFP nets when ... |
format |
Article in Journal/Newspaper |
author |
Thomas Syme Judicaël Nounagnon Boris N’dombidjé Martial Gbegbo Abel Agbevo Juniace Ahoga Corine Ngufor |
author_facet |
Thomas Syme Judicaël Nounagnon Boris N’dombidjé Martial Gbegbo Abel Agbevo Juniace Ahoga Corine Ngufor |
author_sort |
Thomas Syme |
title |
Can the performance of pyrethroid-chlorfenapyr nets be reduced when combined with pyrethroid-piperonyl butoxide (PBO) nets? |
title_short |
Can the performance of pyrethroid-chlorfenapyr nets be reduced when combined with pyrethroid-piperonyl butoxide (PBO) nets? |
title_full |
Can the performance of pyrethroid-chlorfenapyr nets be reduced when combined with pyrethroid-piperonyl butoxide (PBO) nets? |
title_fullStr |
Can the performance of pyrethroid-chlorfenapyr nets be reduced when combined with pyrethroid-piperonyl butoxide (PBO) nets? |
title_full_unstemmed |
Can the performance of pyrethroid-chlorfenapyr nets be reduced when combined with pyrethroid-piperonyl butoxide (PBO) nets? |
title_sort |
can the performance of pyrethroid-chlorfenapyr nets be reduced when combined with pyrethroid-piperonyl butoxide (pbo) nets? |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12936-023-04648-6 https://doaj.org/article/0bb61af54cee4454aacc6372dc356a11 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 22, Iss 1, Pp 1-16 (2023) |
op_relation |
https://doi.org/10.1186/s12936-023-04648-6 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04648-6 1475-2875 https://doaj.org/article/0bb61af54cee4454aacc6372dc356a11 |
op_doi |
https://doi.org/10.1186/s12936-023-04648-6 |
container_title |
Malaria Journal |
container_volume |
22 |
container_issue |
1 |
_version_ |
1774715471856140288 |