Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases.
Certain strains of the endosymbiont Wolbachia have the potential to lower the vectorial capacity of mosquito populations and assist in controlling a number of mosquito-borne diseases. An important consideration when introducing Wolbachia-carrying mosquitoes into natural populations is the minimisati...
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ftdoajarticles:oai:doaj.org/article:0b77f6fe3f9e4ae8b901449b05a19bdf 2023-05-15T15:10:15+02:00 Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases. Penelope A Hancock Steven P Sinkins H Charles J Godfray 2011-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001024 https://doaj.org/article/0b77f6fe3f9e4ae8b901449b05a19bdf EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3082501?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001024 https://doaj.org/article/0b77f6fe3f9e4ae8b901449b05a19bdf PLoS Neglected Tropical Diseases, Vol 5, Iss 4, p e1024 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001024 2022-12-31T03:21:34Z Certain strains of the endosymbiont Wolbachia have the potential to lower the vectorial capacity of mosquito populations and assist in controlling a number of mosquito-borne diseases. An important consideration when introducing Wolbachia-carrying mosquitoes into natural populations is the minimisation of any transient increase in disease risk or biting nuisance. This may be achieved by predominantly releasing male mosquitoes. To explore this, we use a sex-structured model of Wolbachia-mosquito interactions. We first show that Wolbachia spread can be initiated with very few infected females provided the infection frequency in males exceeds a threshold. We then consider realistic introduction scenarios involving the release of batches of infected mosquitoes, incorporating seasonal fluctuations in population size. For a range of assumptions about mosquito population dynamics we find that male-biased releases allow the infection to spread after the introduction of low numbers of females, many fewer than with equal sex-ratio releases. We extend the model to estimate the transmission rate of a mosquito-borne pathogen over the course of Wolbachia establishment. For a range of release strategies we demonstrate that male-biased release of Wolbachia-infected mosquitoes can cause substantial transmission reductions without transiently increasing disease risk. The results show the importance of including mosquito population dynamics in studying Wolbachia spread and that male-biased releases can be an effective and safe way of rapidly establishing the symbiont in mosquito populations. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 4 e1024 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Penelope A Hancock Steven P Sinkins H Charles J Godfray Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Certain strains of the endosymbiont Wolbachia have the potential to lower the vectorial capacity of mosquito populations and assist in controlling a number of mosquito-borne diseases. An important consideration when introducing Wolbachia-carrying mosquitoes into natural populations is the minimisation of any transient increase in disease risk or biting nuisance. This may be achieved by predominantly releasing male mosquitoes. To explore this, we use a sex-structured model of Wolbachia-mosquito interactions. We first show that Wolbachia spread can be initiated with very few infected females provided the infection frequency in males exceeds a threshold. We then consider realistic introduction scenarios involving the release of batches of infected mosquitoes, incorporating seasonal fluctuations in population size. For a range of assumptions about mosquito population dynamics we find that male-biased releases allow the infection to spread after the introduction of low numbers of females, many fewer than with equal sex-ratio releases. We extend the model to estimate the transmission rate of a mosquito-borne pathogen over the course of Wolbachia establishment. For a range of release strategies we demonstrate that male-biased release of Wolbachia-infected mosquitoes can cause substantial transmission reductions without transiently increasing disease risk. The results show the importance of including mosquito population dynamics in studying Wolbachia spread and that male-biased releases can be an effective and safe way of rapidly establishing the symbiont in mosquito populations. |
format |
Article in Journal/Newspaper |
author |
Penelope A Hancock Steven P Sinkins H Charles J Godfray |
author_facet |
Penelope A Hancock Steven P Sinkins H Charles J Godfray |
author_sort |
Penelope A Hancock |
title |
Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases. |
title_short |
Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases. |
title_full |
Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases. |
title_fullStr |
Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases. |
title_full_unstemmed |
Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases. |
title_sort |
strategies for introducing wolbachia to reduce transmission of mosquito-borne diseases. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001024 https://doaj.org/article/0b77f6fe3f9e4ae8b901449b05a19bdf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 4, p e1024 (2011) |
op_relation |
http://europepmc.org/articles/PMC3082501?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001024 https://doaj.org/article/0b77f6fe3f9e4ae8b901449b05a19bdf |
op_doi |
https://doi.org/10.1371/journal.pntd.0001024 |
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PLoS Neglected Tropical Diseases |
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5 |
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4 |
container_start_page |
e1024 |
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1766341292995903488 |