Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite
Background. Chronic pain is associated with increased morbidity and mortality, predominated by cardiovascular disease and cancer. Investigating related risk factor measures may elucidate the biological burden of chronic pain. Objectives. We hypothesized that chronic pain severity would be positively...
Published in: | Pain Research and Management |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2016
|
Subjects: | |
Online Access: | https://doi.org/10.1155/2016/7657329 https://doaj.org/article/0b5f479582084154a220f366a167d00e |
id |
ftdoajarticles:oai:doaj.org/article:0b5f479582084154a220f366a167d00e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:0b5f479582084154a220f366a167d00e 2024-09-15T18:39:26+00:00 Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite Kimberly T. Sibille Ólöf A. Steingrímsdóttir Roger B. Fillingim Audun Stubhaug Henrik Schirmer Huaihou Chen Bruce S. McEwen Christopher S. Nielsen 2016-01-01T00:00:00Z https://doi.org/10.1155/2016/7657329 https://doaj.org/article/0b5f479582084154a220f366a167d00e EN eng Wiley http://dx.doi.org/10.1155/2016/7657329 https://doaj.org/toc/1203-6765 https://doaj.org/toc/1918-1523 1203-6765 1918-1523 doi:10.1155/2016/7657329 https://doaj.org/article/0b5f479582084154a220f366a167d00e Pain Research and Management, Vol 2016 (2016) Medicine (General) R5-920 article 2016 ftdoajarticles https://doi.org/10.1155/2016/7657329 2024-08-05T17:48:32Z Background. Chronic pain is associated with increased morbidity and mortality, predominated by cardiovascular disease and cancer. Investigating related risk factor measures may elucidate the biological burden of chronic pain. Objectives. We hypothesized that chronic pain severity would be positively associated with the risk factor composite. Methods. Data from 12,982 participants in the 6th Tromsø study were analyzed. Questionnaires included demographics, health behaviors, medical comorbidities, and chronic pain symptoms. The risk factor composite was comprised of body mass index, fibrinogen, C-reactive protein, and triglycerides. Chronic pain severity was characterized by frequency, intensity, time/duration, and total number of pain sites. Results. Individuals with chronic pain had a greater risk factor composite than individuals without chronic pain controlling for covariates and after excluding inflammation-related health conditions (p<0.001). A significant “dose-response” relationship was demonstrated with pain severity (p<0.001). In individuals with chronic pain, the risk factor composite varied by health behavior, exercise, lower levels and smoking, and higher levels. Discussion. The risk factor composite was higher in individuals with chronic pain, greater with increasing pain severity, and influenced by health behaviors. Conclusions. Identification of a biological composite sensitive to pain severity and adaptive/maladaptive behaviors would have significant clinical and research utility. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles Pain Research and Management 2016 1 11 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine (General) R5-920 |
spellingShingle |
Medicine (General) R5-920 Kimberly T. Sibille Ólöf A. Steingrímsdóttir Roger B. Fillingim Audun Stubhaug Henrik Schirmer Huaihou Chen Bruce S. McEwen Christopher S. Nielsen Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
topic_facet |
Medicine (General) R5-920 |
description |
Background. Chronic pain is associated with increased morbidity and mortality, predominated by cardiovascular disease and cancer. Investigating related risk factor measures may elucidate the biological burden of chronic pain. Objectives. We hypothesized that chronic pain severity would be positively associated with the risk factor composite. Methods. Data from 12,982 participants in the 6th Tromsø study were analyzed. Questionnaires included demographics, health behaviors, medical comorbidities, and chronic pain symptoms. The risk factor composite was comprised of body mass index, fibrinogen, C-reactive protein, and triglycerides. Chronic pain severity was characterized by frequency, intensity, time/duration, and total number of pain sites. Results. Individuals with chronic pain had a greater risk factor composite than individuals without chronic pain controlling for covariates and after excluding inflammation-related health conditions (p<0.001). A significant “dose-response” relationship was demonstrated with pain severity (p<0.001). In individuals with chronic pain, the risk factor composite varied by health behavior, exercise, lower levels and smoking, and higher levels. Discussion. The risk factor composite was higher in individuals with chronic pain, greater with increasing pain severity, and influenced by health behaviors. Conclusions. Identification of a biological composite sensitive to pain severity and adaptive/maladaptive behaviors would have significant clinical and research utility. |
format |
Article in Journal/Newspaper |
author |
Kimberly T. Sibille Ólöf A. Steingrímsdóttir Roger B. Fillingim Audun Stubhaug Henrik Schirmer Huaihou Chen Bruce S. McEwen Christopher S. Nielsen |
author_facet |
Kimberly T. Sibille Ólöf A. Steingrímsdóttir Roger B. Fillingim Audun Stubhaug Henrik Schirmer Huaihou Chen Bruce S. McEwen Christopher S. Nielsen |
author_sort |
Kimberly T. Sibille |
title |
Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
title_short |
Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
title_full |
Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
title_fullStr |
Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
title_full_unstemmed |
Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite |
title_sort |
investigating the burden of chronic pain: an inflammatory and metabolic composite |
publisher |
Wiley |
publishDate |
2016 |
url |
https://doi.org/10.1155/2016/7657329 https://doaj.org/article/0b5f479582084154a220f366a167d00e |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Pain Research and Management, Vol 2016 (2016) |
op_relation |
http://dx.doi.org/10.1155/2016/7657329 https://doaj.org/toc/1203-6765 https://doaj.org/toc/1918-1523 1203-6765 1918-1523 doi:10.1155/2016/7657329 https://doaj.org/article/0b5f479582084154a220f366a167d00e |
op_doi |
https://doi.org/10.1155/2016/7657329 |
container_title |
Pain Research and Management |
container_volume |
2016 |
container_start_page |
1 |
op_container_end_page |
11 |
_version_ |
1810483810065711104 |