Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia
Introduction Thrombocytopenia is a common complication in malaria patients. The relationship between abnormal platelet profile and clinical status in malaria patients is unclear. In low and unstable endemic regions where vivax malaria predominates, the hematologic profiles of malaria patients and th...
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ftdoajarticles:oai:doaj.org/article:0b4f5c9160b74ee5ab3a4f205cc5ed50 2023-05-15T15:10:44+02:00 Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia Edgar Leonardo Martínez-Salazar Alberto Tobón-Castaño 2014-06-01T00:00:00Z https://doi.org/10.1590/0037-8682-0078-2014 https://doaj.org/article/0b4f5c9160b74ee5ab3a4f205cc5ed50 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000300341&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0078-2014 https://doaj.org/article/0b4f5c9160b74ee5ab3a4f205cc5ed50 Revista da Sociedade Brasileira de Medicina Tropical, Vol 47, Iss 3, Pp 341-349 (2014) Thrombogram Thrombocytopenia Platelet Plasmodium Severe malaria Colombia Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles https://doi.org/10.1590/0037-8682-0078-2014 2022-12-30T21:27:38Z Introduction Thrombocytopenia is a common complication in malaria patients. The relationship between abnormal platelet profile and clinical status in malaria patients is unclear. In low and unstable endemic regions where vivax malaria predominates, the hematologic profiles of malaria patients and their clinical utility are poorly understood. The aim of this study was to characterize the thrombograms of malaria patients from Colombia, where Plasmodium vivax infection is common, and to explore the relationship between thrombograms and clinical status. Methods Eight hundred sixty-two malaria patients were enrolled, including 533 (61.8%) patients infected with Plasmodium falciparum, 311 (36.1%) patients infected with Plasmodium vivax and 18 (2.1%) patients with mixed infections. Results The most frequently observed changes were low platelet count (PC) and high platelet distribution width (PDW), which were observed in 65% of patients; thrombocytopenia with <50,000 platelets/µL was identified in 11% of patients. Patients with complications had lower PC and plateletcrit (PT) and higher PDW values. A higher risk of thrombocytopenia was identified in patients with severe anemia, neurologic complications, pulmonary complications, liver dysfunction, renal impairment and severe hypoglycemia. The presence of thrombocytopenia (<150,000 platelets/µL) was associated with a higher probability of liver dysfunction. Conclusions Young age, longer duration of illness and higher parasitemia are associated with severe thrombocytopenia. Our study showed that thrombocytopenia is related to malaria complications, especially liver dysfunction. High PDW in patients with severe malaria may explain the mechanisms of thrombocytopenia that is common in this group of patients. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 47 3 341 349 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Thrombogram Thrombocytopenia Platelet Plasmodium Severe malaria Colombia Arctic medicine. Tropical medicine RC955-962 |
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Thrombogram Thrombocytopenia Platelet Plasmodium Severe malaria Colombia Arctic medicine. Tropical medicine RC955-962 Edgar Leonardo Martínez-Salazar Alberto Tobón-Castaño Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia |
topic_facet |
Thrombogram Thrombocytopenia Platelet Plasmodium Severe malaria Colombia Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction Thrombocytopenia is a common complication in malaria patients. The relationship between abnormal platelet profile and clinical status in malaria patients is unclear. In low and unstable endemic regions where vivax malaria predominates, the hematologic profiles of malaria patients and their clinical utility are poorly understood. The aim of this study was to characterize the thrombograms of malaria patients from Colombia, where Plasmodium vivax infection is common, and to explore the relationship between thrombograms and clinical status. Methods Eight hundred sixty-two malaria patients were enrolled, including 533 (61.8%) patients infected with Plasmodium falciparum, 311 (36.1%) patients infected with Plasmodium vivax and 18 (2.1%) patients with mixed infections. Results The most frequently observed changes were low platelet count (PC) and high platelet distribution width (PDW), which were observed in 65% of patients; thrombocytopenia with <50,000 platelets/µL was identified in 11% of patients. Patients with complications had lower PC and plateletcrit (PT) and higher PDW values. A higher risk of thrombocytopenia was identified in patients with severe anemia, neurologic complications, pulmonary complications, liver dysfunction, renal impairment and severe hypoglycemia. The presence of thrombocytopenia (<150,000 platelets/µL) was associated with a higher probability of liver dysfunction. Conclusions Young age, longer duration of illness and higher parasitemia are associated with severe thrombocytopenia. Our study showed that thrombocytopenia is related to malaria complications, especially liver dysfunction. High PDW in patients with severe malaria may explain the mechanisms of thrombocytopenia that is common in this group of patients. |
format |
Article in Journal/Newspaper |
author |
Edgar Leonardo Martínez-Salazar Alberto Tobón-Castaño |
author_facet |
Edgar Leonardo Martínez-Salazar Alberto Tobón-Castaño |
author_sort |
Edgar Leonardo Martínez-Salazar |
title |
Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia |
title_short |
Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia |
title_full |
Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia |
title_fullStr |
Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia |
title_full_unstemmed |
Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia |
title_sort |
platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in colombia |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2014 |
url |
https://doi.org/10.1590/0037-8682-0078-2014 https://doaj.org/article/0b4f5c9160b74ee5ab3a4f205cc5ed50 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 47, Iss 3, Pp 341-349 (2014) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000300341&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0078-2014 https://doaj.org/article/0b4f5c9160b74ee5ab3a4f205cc5ed50 |
op_doi |
https://doi.org/10.1590/0037-8682-0078-2014 |
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47 |
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