Corneal complications following Post Kala-azar Dermal Leishmaniasis treatment.
Post Kala-azar Dermal Leishmaniasis (PKDL) is a sequel of Visceral Leishmaniasis (VL). The patients act as a reservoir for the causative parasite (i.e. Leishmania donovani) and thus should be diagnosed and treated with the utmost urgency to prevent the transmission of the disease. In this study, we...
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ftdoajarticles:oai:doaj.org/article:0b3e038b4ea64b03967890620443a816 2023-05-15T15:07:50+02:00 Corneal complications following Post Kala-azar Dermal Leishmaniasis treatment. Shomik Maruf Proggananda Nath Muhammad Rafiqul Islam Fatima Aktar Azim Anuwarul Dinesh Mondal Ariful Basher 2018-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006781 https://doaj.org/article/0b3e038b4ea64b03967890620443a816 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6160237?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006781 https://doaj.org/article/0b3e038b4ea64b03967890620443a816 PLoS Neglected Tropical Diseases, Vol 12, Iss 9, p e0006781 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006781 2022-12-31T06:33:08Z Post Kala-azar Dermal Leishmaniasis (PKDL) is a sequel of Visceral Leishmaniasis (VL). The patients act as a reservoir for the causative parasite (i.e. Leishmania donovani) and thus should be diagnosed and treated with the utmost urgency to prevent the transmission of the disease. In this study, we tried to report the first instances of corneal complications supposedly associated with Miltefosine (MF), in PKDL patients and the probable pathophysiology of such events. The recently rejuvenated National Kala-azar Elimination Program in Bangladesh has put great emphasis on monitoring all the leishmaniasis patients to investigate possible adverse drug reactions (ADR). A total of 194 patients have received Miltefosine for the treatment of Post Kala-azar Dermal Leishmaniasis. So far five patients were found to have developed unilateral ophthalmic complications during the periods from May 2016 to October 2017, after being treated with MF for PKDL. Unfortunately, one of whom had to go through complete evisceration of the affected eyeball. Despite the fact that MF is the only oral formulation of choice to treat PKDL, occurrences of such unexpected ADRs after MF administration urges the exploration of the pathogenesis of such incidents and determine measures to avert such occurrences from happening in future. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Azar ENVELOPE(-63.733,-63.733,-64.983,-64.983) PLOS Neglected Tropical Diseases 12 9 e0006781 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Shomik Maruf Proggananda Nath Muhammad Rafiqul Islam Fatima Aktar Azim Anuwarul Dinesh Mondal Ariful Basher Corneal complications following Post Kala-azar Dermal Leishmaniasis treatment. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Post Kala-azar Dermal Leishmaniasis (PKDL) is a sequel of Visceral Leishmaniasis (VL). The patients act as a reservoir for the causative parasite (i.e. Leishmania donovani) and thus should be diagnosed and treated with the utmost urgency to prevent the transmission of the disease. In this study, we tried to report the first instances of corneal complications supposedly associated with Miltefosine (MF), in PKDL patients and the probable pathophysiology of such events. The recently rejuvenated National Kala-azar Elimination Program in Bangladesh has put great emphasis on monitoring all the leishmaniasis patients to investigate possible adverse drug reactions (ADR). A total of 194 patients have received Miltefosine for the treatment of Post Kala-azar Dermal Leishmaniasis. So far five patients were found to have developed unilateral ophthalmic complications during the periods from May 2016 to October 2017, after being treated with MF for PKDL. Unfortunately, one of whom had to go through complete evisceration of the affected eyeball. Despite the fact that MF is the only oral formulation of choice to treat PKDL, occurrences of such unexpected ADRs after MF administration urges the exploration of the pathogenesis of such incidents and determine measures to avert such occurrences from happening in future. |
format |
Article in Journal/Newspaper |
author |
Shomik Maruf Proggananda Nath Muhammad Rafiqul Islam Fatima Aktar Azim Anuwarul Dinesh Mondal Ariful Basher |
author_facet |
Shomik Maruf Proggananda Nath Muhammad Rafiqul Islam Fatima Aktar Azim Anuwarul Dinesh Mondal Ariful Basher |
author_sort |
Shomik Maruf |
title |
Corneal complications following Post Kala-azar Dermal Leishmaniasis treatment. |
title_short |
Corneal complications following Post Kala-azar Dermal Leishmaniasis treatment. |
title_full |
Corneal complications following Post Kala-azar Dermal Leishmaniasis treatment. |
title_fullStr |
Corneal complications following Post Kala-azar Dermal Leishmaniasis treatment. |
title_full_unstemmed |
Corneal complications following Post Kala-azar Dermal Leishmaniasis treatment. |
title_sort |
corneal complications following post kala-azar dermal leishmaniasis treatment. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006781 https://doaj.org/article/0b3e038b4ea64b03967890620443a816 |
long_lat |
ENVELOPE(-63.733,-63.733,-64.983,-64.983) |
geographic |
Arctic Azar |
geographic_facet |
Arctic Azar |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 9, p e0006781 (2018) |
op_relation |
http://europepmc.org/articles/PMC6160237?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006781 https://doaj.org/article/0b3e038b4ea64b03967890620443a816 |
op_doi |
https://doi.org/10.1371/journal.pntd.0006781 |
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PLOS Neglected Tropical Diseases |
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12 |
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9 |
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e0006781 |
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