Proteomic changes in various organs of Haemaphysalis longicornis under long-term starvation.
Haemaphysalis longicornis (Neumann), a tick of public health and veterinary importance, spend the major part of their life cycle off-host, especially the adult host-seeking period. Thus, they have to contend with prolonged starvation. Here, we investigated the underlying molecular mechanism of tick...
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ftdoajarticles:oai:doaj.org/article:0b283d40fc74427e9a1b2fca323ae8ff 2023-05-15T15:06:04+02:00 Proteomic changes in various organs of Haemaphysalis longicornis under long-term starvation. Ningmei Wang Han Wang Aimeng Ji Ning Li Guomin Chang Jingze Liu Desmond O Agwunobi Hui Wang 2022-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010692 https://doaj.org/article/0b283d40fc74427e9a1b2fca323ae8ff EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010692 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010692 https://doaj.org/article/0b283d40fc74427e9a1b2fca323ae8ff PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010692 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010692 2022-12-30T19:58:50Z Haemaphysalis longicornis (Neumann), a tick of public health and veterinary importance, spend the major part of their life cycle off-host, especially the adult host-seeking period. Thus, they have to contend with prolonged starvation. Here, we investigated the underlying molecular mechanism of tick starvation endurance in the salivary glands, midguts, ovaries, and Malpighian tubules of starved H. longicornis ticks using the data-independent acquisition quantitative proteomic approach to study the proteome changes. Essential synthases such as glutamate synthase, citrate synthase, and ATP synthase were up-regulated probably due to increased proteolysis and amino acid catabolism during starvation. The up-regulation of succinate dehydrogenase, ATP synthase, cytochrome c oxidase, and ADP/ATP translocase closely fits with an increased oxidative phosphorylation function during starvation. The differential expression of superoxide dismutase, glutathione reductase, glutathione S-transferase, thioredoxin, and peroxiredoxin indicated fasting-induced oxidative stress. The up-regulation of heat shock proteins could imply the activation of a protective mechanism that checks excessive protein breakdown during starvation stress. The results of this study could provide useful information about the vulnerabilities of ticks that could aid in tick control efforts. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 8 e0010692 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ningmei Wang Han Wang Aimeng Ji Ning Li Guomin Chang Jingze Liu Desmond O Agwunobi Hui Wang Proteomic changes in various organs of Haemaphysalis longicornis under long-term starvation. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Haemaphysalis longicornis (Neumann), a tick of public health and veterinary importance, spend the major part of their life cycle off-host, especially the adult host-seeking period. Thus, they have to contend with prolonged starvation. Here, we investigated the underlying molecular mechanism of tick starvation endurance in the salivary glands, midguts, ovaries, and Malpighian tubules of starved H. longicornis ticks using the data-independent acquisition quantitative proteomic approach to study the proteome changes. Essential synthases such as glutamate synthase, citrate synthase, and ATP synthase were up-regulated probably due to increased proteolysis and amino acid catabolism during starvation. The up-regulation of succinate dehydrogenase, ATP synthase, cytochrome c oxidase, and ADP/ATP translocase closely fits with an increased oxidative phosphorylation function during starvation. The differential expression of superoxide dismutase, glutathione reductase, glutathione S-transferase, thioredoxin, and peroxiredoxin indicated fasting-induced oxidative stress. The up-regulation of heat shock proteins could imply the activation of a protective mechanism that checks excessive protein breakdown during starvation stress. The results of this study could provide useful information about the vulnerabilities of ticks that could aid in tick control efforts. |
format |
Article in Journal/Newspaper |
author |
Ningmei Wang Han Wang Aimeng Ji Ning Li Guomin Chang Jingze Liu Desmond O Agwunobi Hui Wang |
author_facet |
Ningmei Wang Han Wang Aimeng Ji Ning Li Guomin Chang Jingze Liu Desmond O Agwunobi Hui Wang |
author_sort |
Ningmei Wang |
title |
Proteomic changes in various organs of Haemaphysalis longicornis under long-term starvation. |
title_short |
Proteomic changes in various organs of Haemaphysalis longicornis under long-term starvation. |
title_full |
Proteomic changes in various organs of Haemaphysalis longicornis under long-term starvation. |
title_fullStr |
Proteomic changes in various organs of Haemaphysalis longicornis under long-term starvation. |
title_full_unstemmed |
Proteomic changes in various organs of Haemaphysalis longicornis under long-term starvation. |
title_sort |
proteomic changes in various organs of haemaphysalis longicornis under long-term starvation. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010692 https://doaj.org/article/0b283d40fc74427e9a1b2fca323ae8ff |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010692 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010692 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010692 https://doaj.org/article/0b283d40fc74427e9a1b2fca323ae8ff |
op_doi |
https://doi.org/10.1371/journal.pntd.0010692 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
8 |
container_start_page |
e0010692 |
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1766337732847599616 |