Association of C-reactive protein with future development of diabetes: a population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007–2016
Objectives The extent to which observed associations between high-sensitivity C-reactive protein (hs-CRP) and incident diabetes are explained by obesity and hypertension remains unclear. This study aimed to investigate the association of hs-CRP with developing diabetes in a Norwegian general populat...
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ftdoajarticles:oai:doaj.org/article:0b1f7497ac224bf7aa89ff80a78480c0 2023-11-05T03:45:23+01:00 Association of C-reactive protein with future development of diabetes: a population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007–2016 Sarah Cook Laila Arnesdatter Hopstock Kit I Tong 2023-09-01T00:00:00Z https://doi.org/10.1136/bmjopen-2022-070284 https://doaj.org/article/0b1f7497ac224bf7aa89ff80a78480c0 EN eng BMJ Publishing Group https://bmjopen.bmj.com/content/13/9/e070284.full https://doaj.org/toc/2044-6055 doi:10.1136/bmjopen-2022-070284 2044-6055 https://doaj.org/article/0b1f7497ac224bf7aa89ff80a78480c0 BMJ Open, Vol 13, Iss 9 (2023) Medicine R article 2023 ftdoajarticles https://doi.org/10.1136/bmjopen-2022-070284 2023-10-08T00:38:04Z Objectives The extent to which observed associations between high-sensitivity C-reactive protein (hs-CRP) and incident diabetes are explained by obesity and hypertension remains unclear. This study aimed to investigate the association of hs-CRP with developing diabetes in a Norwegian general population sample.Design A cohort study using two population-based surveys of the Tromsø Study: the sixth survey Tromsø6 (2007–2008) as baseline and the seventh survey Tromsø7 (2015–2016) at follow-up.Setting Tromsø municipality of Norway, a country with increasing proportion of older adults and a high prevalence of overweight, obesity and hypertension.Participants 8067 women and men without diabetes, aged 30–87 years, at baseline Tromsø6 who subsequently also participated in Tromsø7.Outcome measures Diabetes defined by self-reported diabetes, diabetes medication use and/or HbA1c≥6.5% (≥48 mmol/mol) was modelled by logistic regression for the association with baseline hs-CRP, either stratified into three quantiles or as continuous variable, adjusted for demographic factors, behavioural and cardiovascular risk factors, lipid-lowering medication use, and hypertension. Interactions by sex, body mass index (BMI), hypertension or abdominal obesity were assessed by adding interaction terms in the fully adjusted model.Results There were 320 (4.0%) diabetes cases after 7 years. After multivariable adjustment including obesity and hypertension, individuals in the highest hs-CRP tertile 3 had 73% higher odds of developing diabetes (OR 1.73; p=0.004; 95% CI 1.20 to 2.49) when compared with the lowest tertile or 28% higher odds of incidence per one-log of hs-CRP increment (OR 1.28; p=0.003; 95% CI 1.09 to 1.50). There was no evidence for interaction between hs-CRP and sex, hypertension, BMI or abdominal obesity.Conclusions Raised hs-CRP was associated with future diabetes development in a Norwegian adult population sample. The CRP-diabetes association could not be fully explained by obesity or hypertension. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles BMJ Open 13 9 e070284 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Medicine R |
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Medicine R Sarah Cook Laila Arnesdatter Hopstock Kit I Tong Association of C-reactive protein with future development of diabetes: a population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007–2016 |
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Medicine R |
description |
Objectives The extent to which observed associations between high-sensitivity C-reactive protein (hs-CRP) and incident diabetes are explained by obesity and hypertension remains unclear. This study aimed to investigate the association of hs-CRP with developing diabetes in a Norwegian general population sample.Design A cohort study using two population-based surveys of the Tromsø Study: the sixth survey Tromsø6 (2007–2008) as baseline and the seventh survey Tromsø7 (2015–2016) at follow-up.Setting Tromsø municipality of Norway, a country with increasing proportion of older adults and a high prevalence of overweight, obesity and hypertension.Participants 8067 women and men without diabetes, aged 30–87 years, at baseline Tromsø6 who subsequently also participated in Tromsø7.Outcome measures Diabetes defined by self-reported diabetes, diabetes medication use and/or HbA1c≥6.5% (≥48 mmol/mol) was modelled by logistic regression for the association with baseline hs-CRP, either stratified into three quantiles or as continuous variable, adjusted for demographic factors, behavioural and cardiovascular risk factors, lipid-lowering medication use, and hypertension. Interactions by sex, body mass index (BMI), hypertension or abdominal obesity were assessed by adding interaction terms in the fully adjusted model.Results There were 320 (4.0%) diabetes cases after 7 years. After multivariable adjustment including obesity and hypertension, individuals in the highest hs-CRP tertile 3 had 73% higher odds of developing diabetes (OR 1.73; p=0.004; 95% CI 1.20 to 2.49) when compared with the lowest tertile or 28% higher odds of incidence per one-log of hs-CRP increment (OR 1.28; p=0.003; 95% CI 1.09 to 1.50). There was no evidence for interaction between hs-CRP and sex, hypertension, BMI or abdominal obesity.Conclusions Raised hs-CRP was associated with future diabetes development in a Norwegian adult population sample. The CRP-diabetes association could not be fully explained by obesity or hypertension. |
format |
Article in Journal/Newspaper |
author |
Sarah Cook Laila Arnesdatter Hopstock Kit I Tong |
author_facet |
Sarah Cook Laila Arnesdatter Hopstock Kit I Tong |
author_sort |
Sarah Cook |
title |
Association of C-reactive protein with future development of diabetes: a population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007–2016 |
title_short |
Association of C-reactive protein with future development of diabetes: a population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007–2016 |
title_full |
Association of C-reactive protein with future development of diabetes: a population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007–2016 |
title_fullStr |
Association of C-reactive protein with future development of diabetes: a population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007–2016 |
title_full_unstemmed |
Association of C-reactive protein with future development of diabetes: a population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007–2016 |
title_sort |
association of c-reactive protein with future development of diabetes: a population-based 7-year cohort study among norwegian adults aged 30 and older in the tromsø study 2007–2016 |
publisher |
BMJ Publishing Group |
publishDate |
2023 |
url |
https://doi.org/10.1136/bmjopen-2022-070284 https://doaj.org/article/0b1f7497ac224bf7aa89ff80a78480c0 |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
BMJ Open, Vol 13, Iss 9 (2023) |
op_relation |
https://bmjopen.bmj.com/content/13/9/e070284.full https://doaj.org/toc/2044-6055 doi:10.1136/bmjopen-2022-070284 2044-6055 https://doaj.org/article/0b1f7497ac224bf7aa89ff80a78480c0 |
op_doi |
https://doi.org/10.1136/bmjopen-2022-070284 |
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BMJ Open |
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13 |
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9 |
container_start_page |
e070284 |
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1781707489486569472 |