Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana.
Background Guyana is one of four countries in the Latin American Region where lymphatic filariasis (LF) remains endemic. In preparation for the introduction of a new triple drug therapy regimen (ivermectin, diethylcarbamazine, and albendazole (IDA)) in 2019, an acceptability study was embedded withi...
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ftdoajarticles:oai:doaj.org/article:0b1b563103284b228fb03e3eaf669527 2023-05-15T15:13:00+02:00 Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana. Reza A Niles Charles R Thickstun Horace Cox Daniel Dilliott Clara R Burgert-Brucker Emma M Harding-Esch Nikita Clementson Annastacia Sampson Jean Seme Alexandre Ana C Morice Trejos Ronaldo G Carvalho Scholte Alison Krentel 2021-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009596 https://doaj.org/article/0b1b563103284b228fb03e3eaf669527 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009596 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009596 https://doaj.org/article/0b1b563103284b228fb03e3eaf669527 PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009596 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009596 2022-12-31T15:16:59Z Background Guyana is one of four countries in the Latin American Region where lymphatic filariasis (LF) remains endemic. In preparation for the introduction of a new triple drug therapy regimen (ivermectin, diethylcarbamazine, and albendazole (IDA)) in 2019, an acceptability study was embedded within sentinel site mapping in four regions to assess mass drug administration (MDA) coverage and compliance, acceptability, and perceptions about treatment and disease. The results from this survey would inform the rollout of IDA in Guyana in 2019. Methods Data collection for the study occurred in August 2019, using a validated questionnaire administered by trained enumerators. Across all regions, a total of 1,248 participants were sampled by the Filarial Mapping team. Four-hundred and fifty-one participants aged over 18 years were randomly selected for participation in an expanded acceptability questionnaire. All data were captured in Secure Data Kit (SDK). Results Acceptability was measured using a mean acceptability score. Unadjusted mean scores ranged from 24.6 to 29.3, with 22.5 as the threshold of acceptability. Regional variation occurred across many indicators of interest: self-rated understanding about LF, mechanisms of LF transmission, LF drug safety and history of treatment during MDA. Region IV (Georgetown) recorded higher knowledge about LF, but lower compliance and acceptability. Number of pills was not perceived as a concern. Conclusion Acceptability of MDA was good across all four regions under study. Results from this study set a baseline level for key indicators and acceptability, from which the acceptability of IDA can be measured. Regional variations across indicators suggest that localized approaches should be considered for social mobilization and MDA delivery to capture these contextual differences. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Ida ENVELOPE(170.483,170.483,-83.583,-83.583) PLOS Neglected Tropical Diseases 15 9 e0009596 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Reza A Niles Charles R Thickstun Horace Cox Daniel Dilliott Clara R Burgert-Brucker Emma M Harding-Esch Nikita Clementson Annastacia Sampson Jean Seme Alexandre Ana C Morice Trejos Ronaldo G Carvalho Scholte Alison Krentel Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Guyana is one of four countries in the Latin American Region where lymphatic filariasis (LF) remains endemic. In preparation for the introduction of a new triple drug therapy regimen (ivermectin, diethylcarbamazine, and albendazole (IDA)) in 2019, an acceptability study was embedded within sentinel site mapping in four regions to assess mass drug administration (MDA) coverage and compliance, acceptability, and perceptions about treatment and disease. The results from this survey would inform the rollout of IDA in Guyana in 2019. Methods Data collection for the study occurred in August 2019, using a validated questionnaire administered by trained enumerators. Across all regions, a total of 1,248 participants were sampled by the Filarial Mapping team. Four-hundred and fifty-one participants aged over 18 years were randomly selected for participation in an expanded acceptability questionnaire. All data were captured in Secure Data Kit (SDK). Results Acceptability was measured using a mean acceptability score. Unadjusted mean scores ranged from 24.6 to 29.3, with 22.5 as the threshold of acceptability. Regional variation occurred across many indicators of interest: self-rated understanding about LF, mechanisms of LF transmission, LF drug safety and history of treatment during MDA. Region IV (Georgetown) recorded higher knowledge about LF, but lower compliance and acceptability. Number of pills was not perceived as a concern. Conclusion Acceptability of MDA was good across all four regions under study. Results from this study set a baseline level for key indicators and acceptability, from which the acceptability of IDA can be measured. Regional variations across indicators suggest that localized approaches should be considered for social mobilization and MDA delivery to capture these contextual differences. |
format |
Article in Journal/Newspaper |
author |
Reza A Niles Charles R Thickstun Horace Cox Daniel Dilliott Clara R Burgert-Brucker Emma M Harding-Esch Nikita Clementson Annastacia Sampson Jean Seme Alexandre Ana C Morice Trejos Ronaldo G Carvalho Scholte Alison Krentel |
author_facet |
Reza A Niles Charles R Thickstun Horace Cox Daniel Dilliott Clara R Burgert-Brucker Emma M Harding-Esch Nikita Clementson Annastacia Sampson Jean Seme Alexandre Ana C Morice Trejos Ronaldo G Carvalho Scholte Alison Krentel |
author_sort |
Reza A Niles |
title |
Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana. |
title_short |
Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana. |
title_full |
Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana. |
title_fullStr |
Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana. |
title_full_unstemmed |
Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana. |
title_sort |
assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in guyana. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009596 https://doaj.org/article/0b1b563103284b228fb03e3eaf669527 |
long_lat |
ENVELOPE(170.483,170.483,-83.583,-83.583) |
geographic |
Arctic Ida |
geographic_facet |
Arctic Ida |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009596 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009596 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009596 https://doaj.org/article/0b1b563103284b228fb03e3eaf669527 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009596 |
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PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
9 |
container_start_page |
e0009596 |
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