Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.
Background Zika virus (ZIKV) has generated global interest in the last five years mostly due to its resurgence in the Americas between 2015 and 2016. It was previously thought to be a self-limiting infection causing febrile illness in less than one quarter of those infected. However, a rise in birth...
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Online Access: | https://doi.org/10.1371/journal.pntd.0009516 https://doaj.org/article/0abe5e62ad22415c8d5b812135c2e174 |
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ftdoajarticles:oai:doaj.org/article:0abe5e62ad22415c8d5b812135c2e174 2023-05-15T15:15:10+02:00 Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review. Sheliza Halani Panashe E Tombindo Ryan O'Reilly Rafael N Miranda Laura K Erdman Clare Whitehead Joanna M Bielecki Lauren Ramsay Raphael Ximenes Justin Boyle Carsten Krueger Shannon Willmott Shaun K Morris Kellie E Murphy Beate Sander 2021-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009516 https://doaj.org/article/0abe5e62ad22415c8d5b812135c2e174 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009516 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009516 https://doaj.org/article/0abe5e62ad22415c8d5b812135c2e174 PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009516 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009516 2022-12-31T14:32:28Z Background Zika virus (ZIKV) has generated global interest in the last five years mostly due to its resurgence in the Americas between 2015 and 2016. It was previously thought to be a self-limiting infection causing febrile illness in less than one quarter of those infected. However, a rise in birth defects amongst children born to infected pregnant women, as well as increases in neurological manifestations in adults has been demonstrated. We systemically reviewed the literature to understand clinical manifestations and health outcomes in adults globally. Methods This review was registered prospectively with PROPSERO (CRD 42018096558). We systematically searched for studies in six databases from inception to the end of September 2020. There were no language restrictions. Critical appraisal was completed using the Joanna Briggs Institute Critical Appraisal Tools. Findings We identified 73 studies globally that reported clinical outcomes in ZIKV-infected adults, of which 55 studies were from the Americas. For further analysis, we considered studies that met 70% of critical appraisal criteria and described subjects with confirmed ZIKV. The most common symptoms included: exanthema (5,456/6,129; 89%), arthralgia (3,809/6,093; 63%), fever (3,787/6,124; 62%), conjunctivitis (2,738/3,283; 45%), myalgia (2,498/5,192; 48%), headache (2,165/4,722; 46%), and diarrhea (337/2,622; 13%). 36/14,335 (0.3%) of infected cases developed neurologic sequelae, of which 75% were Guillain-Barré Syndrome (GBS). Several subjects reported recovery from peak of neurological complications, though some endured chronic disability. Mortality was rare (0.1%) and hospitalization (11%) was often associated with co-morbidities or GBS. Conclusions The ZIKV literature in adults was predominantly from the Americas. The most common systemic symptoms were exanthema, fever, arthralgia, and conjunctivitis; GBS was the most prevalent neurological complication. Future ZIKV studies are warranted with standardization of testing and case definitions, ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Barré ENVELOPE(-68.550,-68.550,-67.500,-67.500) Briggs ENVELOPE(-63.017,-63.017,-64.517,-64.517) PLOS Neglected Tropical Diseases 15 7 e0009516 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sheliza Halani Panashe E Tombindo Ryan O'Reilly Rafael N Miranda Laura K Erdman Clare Whitehead Joanna M Bielecki Lauren Ramsay Raphael Ximenes Justin Boyle Carsten Krueger Shannon Willmott Shaun K Morris Kellie E Murphy Beate Sander Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Zika virus (ZIKV) has generated global interest in the last five years mostly due to its resurgence in the Americas between 2015 and 2016. It was previously thought to be a self-limiting infection causing febrile illness in less than one quarter of those infected. However, a rise in birth defects amongst children born to infected pregnant women, as well as increases in neurological manifestations in adults has been demonstrated. We systemically reviewed the literature to understand clinical manifestations and health outcomes in adults globally. Methods This review was registered prospectively with PROPSERO (CRD 42018096558). We systematically searched for studies in six databases from inception to the end of September 2020. There were no language restrictions. Critical appraisal was completed using the Joanna Briggs Institute Critical Appraisal Tools. Findings We identified 73 studies globally that reported clinical outcomes in ZIKV-infected adults, of which 55 studies were from the Americas. For further analysis, we considered studies that met 70% of critical appraisal criteria and described subjects with confirmed ZIKV. The most common symptoms included: exanthema (5,456/6,129; 89%), arthralgia (3,809/6,093; 63%), fever (3,787/6,124; 62%), conjunctivitis (2,738/3,283; 45%), myalgia (2,498/5,192; 48%), headache (2,165/4,722; 46%), and diarrhea (337/2,622; 13%). 36/14,335 (0.3%) of infected cases developed neurologic sequelae, of which 75% were Guillain-Barré Syndrome (GBS). Several subjects reported recovery from peak of neurological complications, though some endured chronic disability. Mortality was rare (0.1%) and hospitalization (11%) was often associated with co-morbidities or GBS. Conclusions The ZIKV literature in adults was predominantly from the Americas. The most common systemic symptoms were exanthema, fever, arthralgia, and conjunctivitis; GBS was the most prevalent neurological complication. Future ZIKV studies are warranted with standardization of testing and case definitions, ... |
format |
Article in Journal/Newspaper |
author |
Sheliza Halani Panashe E Tombindo Ryan O'Reilly Rafael N Miranda Laura K Erdman Clare Whitehead Joanna M Bielecki Lauren Ramsay Raphael Ximenes Justin Boyle Carsten Krueger Shannon Willmott Shaun K Morris Kellie E Murphy Beate Sander |
author_facet |
Sheliza Halani Panashe E Tombindo Ryan O'Reilly Rafael N Miranda Laura K Erdman Clare Whitehead Joanna M Bielecki Lauren Ramsay Raphael Ximenes Justin Boyle Carsten Krueger Shannon Willmott Shaun K Morris Kellie E Murphy Beate Sander |
author_sort |
Sheliza Halani |
title |
Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review. |
title_short |
Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review. |
title_full |
Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review. |
title_fullStr |
Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review. |
title_full_unstemmed |
Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review. |
title_sort |
clinical manifestations and health outcomes associated with zika virus infections in adults: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009516 https://doaj.org/article/0abe5e62ad22415c8d5b812135c2e174 |
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ENVELOPE(-68.550,-68.550,-67.500,-67.500) ENVELOPE(-63.017,-63.017,-64.517,-64.517) |
geographic |
Arctic Barré Briggs |
geographic_facet |
Arctic Barré Briggs |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009516 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009516 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009516 https://doaj.org/article/0abe5e62ad22415c8d5b812135c2e174 |
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https://doi.org/10.1371/journal.pntd.0009516 |
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PLOS Neglected Tropical Diseases |
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e0009516 |
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