Malaria serology data from the Guiana shield: first insight in IgG antibody responses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae antigens in Suriname
Abstract Background Suriname has accomplished a steep decline in malaria burden, even reaching elimination levels. Plasmodium serology data are not available for Suriname and even extremely scarce within the region, therefore malaria serology testing was introduced, country customized cut-off values...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2020
|
Subjects: | |
Online Access: | https://doi.org/10.1186/s12936-020-03434-y https://doaj.org/article/0ab1866c8f4a4c8f8bc9c759bd3ab3a7 |
id |
ftdoajarticles:oai:doaj.org/article:0ab1866c8f4a4c8f8bc9c759bd3ab3a7 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:0ab1866c8f4a4c8f8bc9c759bd3ab3a7 2023-05-15T15:16:54+02:00 Malaria serology data from the Guiana shield: first insight in IgG antibody responses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae antigens in Suriname Mergiory Y. Labadie-Bracho Farah T. van Genderen Malti R. Adhin 2020-10-01T00:00:00Z https://doi.org/10.1186/s12936-020-03434-y https://doaj.org/article/0ab1866c8f4a4c8f8bc9c759bd3ab3a7 EN eng BMC http://link.springer.com/article/10.1186/s12936-020-03434-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03434-y 1475-2875 https://doaj.org/article/0ab1866c8f4a4c8f8bc9c759bd3ab3a7 Malaria Journal, Vol 19, Iss 1, Pp 1-14 (2020) Suriname Guiana Shield Seroprevalence Plasmodium Customized cut-off value Antibody diversity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-03434-y 2022-12-31T03:28:06Z Abstract Background Suriname has accomplished a steep decline in malaria burden, even reaching elimination levels. Plasmodium serology data are not available for Suriname and even extremely scarce within the region, therefore malaria serology testing was introduced, country customized cut-off values were determined and a study was performed to explore the antibody status for Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae. Methods A cross-sectional survey was conducted between July 2017 and March 2018 in two areas of the interior with different malaria settings: Stoelmanseiland, representing Maroon villages and Benzdorp, a gold mining area, with mostly Brazilian miners. Dried blood spots (DBS) were collected (n = 197) and antibody presence against seven Plasmodium antigens was detected using a multiplex bead-based, IgG antibody assay. Demographic information was gathered through a questionnaire. Country customized cut-off values were generated from a Surinamese malaria-naïve reference population (n = 50). Results Serological analysis for the reference population revealed cut-off values ranging from 14 MFI for LSA-1 to 177 MFI for PmMSP-119. Seroprevalence against any of the three MSP-119 antibodies was similar in both regions and surpassed 75%. Single seropositivity against PfMSP-119 antibodies was higher in Stoelmanseiland (27.0%) than Benzdorp (9.3%), in line with the historical malaria burden of Stoelmanseiland, while the reverse was observed for PvMSP-119 antibodies. Despite sporadic reports of P. malariae infections, PmMSP-119 antibody presence was 39.6%. A more detailed examination of P. falciparum serology data displayed a higher seroprevalence in villagers (90.7%) than in Brazilians (64.6%) and a highly diverse antigenic response with 22 distinct antibody combinations. Conclusions The results on the malaria antibody signature of Maroon villagers and Brazilian miners living in Suriname displayed a high Plasmodium seroprevalence, especially for P. falciparum in villagers, still reflecting ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Suriname Guiana Shield Seroprevalence Plasmodium Customized cut-off value Antibody diversity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Suriname Guiana Shield Seroprevalence Plasmodium Customized cut-off value Antibody diversity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Mergiory Y. Labadie-Bracho Farah T. van Genderen Malti R. Adhin Malaria serology data from the Guiana shield: first insight in IgG antibody responses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae antigens in Suriname |
topic_facet |
Suriname Guiana Shield Seroprevalence Plasmodium Customized cut-off value Antibody diversity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Suriname has accomplished a steep decline in malaria burden, even reaching elimination levels. Plasmodium serology data are not available for Suriname and even extremely scarce within the region, therefore malaria serology testing was introduced, country customized cut-off values were determined and a study was performed to explore the antibody status for Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae. Methods A cross-sectional survey was conducted between July 2017 and March 2018 in two areas of the interior with different malaria settings: Stoelmanseiland, representing Maroon villages and Benzdorp, a gold mining area, with mostly Brazilian miners. Dried blood spots (DBS) were collected (n = 197) and antibody presence against seven Plasmodium antigens was detected using a multiplex bead-based, IgG antibody assay. Demographic information was gathered through a questionnaire. Country customized cut-off values were generated from a Surinamese malaria-naïve reference population (n = 50). Results Serological analysis for the reference population revealed cut-off values ranging from 14 MFI for LSA-1 to 177 MFI for PmMSP-119. Seroprevalence against any of the three MSP-119 antibodies was similar in both regions and surpassed 75%. Single seropositivity against PfMSP-119 antibodies was higher in Stoelmanseiland (27.0%) than Benzdorp (9.3%), in line with the historical malaria burden of Stoelmanseiland, while the reverse was observed for PvMSP-119 antibodies. Despite sporadic reports of P. malariae infections, PmMSP-119 antibody presence was 39.6%. A more detailed examination of P. falciparum serology data displayed a higher seroprevalence in villagers (90.7%) than in Brazilians (64.6%) and a highly diverse antigenic response with 22 distinct antibody combinations. Conclusions The results on the malaria antibody signature of Maroon villagers and Brazilian miners living in Suriname displayed a high Plasmodium seroprevalence, especially for P. falciparum in villagers, still reflecting ... |
format |
Article in Journal/Newspaper |
author |
Mergiory Y. Labadie-Bracho Farah T. van Genderen Malti R. Adhin |
author_facet |
Mergiory Y. Labadie-Bracho Farah T. van Genderen Malti R. Adhin |
author_sort |
Mergiory Y. Labadie-Bracho |
title |
Malaria serology data from the Guiana shield: first insight in IgG antibody responses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae antigens in Suriname |
title_short |
Malaria serology data from the Guiana shield: first insight in IgG antibody responses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae antigens in Suriname |
title_full |
Malaria serology data from the Guiana shield: first insight in IgG antibody responses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae antigens in Suriname |
title_fullStr |
Malaria serology data from the Guiana shield: first insight in IgG antibody responses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae antigens in Suriname |
title_full_unstemmed |
Malaria serology data from the Guiana shield: first insight in IgG antibody responses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae antigens in Suriname |
title_sort |
malaria serology data from the guiana shield: first insight in igg antibody responses to plasmodium falciparum, plasmodium vivax and plasmodium malariae antigens in suriname |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-03434-y https://doaj.org/article/0ab1866c8f4a4c8f8bc9c759bd3ab3a7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-14 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s12936-020-03434-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03434-y 1475-2875 https://doaj.org/article/0ab1866c8f4a4c8f8bc9c759bd3ab3a7 |
op_doi |
https://doi.org/10.1186/s12936-020-03434-y |
container_title |
Malaria Journal |
container_volume |
19 |
container_issue |
1 |
_version_ |
1766347189643116544 |