Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea.
Onchocerciasis, also known as river blindness, is a parasitic disease. More than 99 percent of all cases occur in Africa. Bioko Island (Equatorial Guinea) is the only island endemic for onchocerciasis in the world. Since 2005, when vector Simulium yahense was eliminated, there have not been any repo...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0006471 https://doaj.org/article/0a9fd848edd544039781c1ab7eec2b2f |
id |
ftdoajarticles:oai:doaj.org/article:0a9fd848edd544039781c1ab7eec2b2f |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:0a9fd848edd544039781c1ab7eec2b2f 2023-05-15T15:14:56+02:00 Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea. Zaida Herrador Belén Garcia Policarpo Ncogo Maria Jesus Perteguer Jose Miguel Rubio Eva Rivas Marta Cimas Guillermo Ordoñez Silvia de Pablos Ana Hernández-González Rufino Nguema Laura Moya María Romay-Barja Teresa Garate Kira Barbre Agustín Benito 2018-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006471 https://doaj.org/article/0a9fd848edd544039781c1ab7eec2b2f EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5953477?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006471 https://doaj.org/article/0a9fd848edd544039781c1ab7eec2b2f PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006471 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006471 2022-12-30T22:30:01Z Onchocerciasis, also known as river blindness, is a parasitic disease. More than 99 percent of all cases occur in Africa. Bioko Island (Equatorial Guinea) is the only island endemic for onchocerciasis in the world. Since 2005, when vector Simulium yahense was eliminated, there have not been any reported cases of infection. This study aimed to demonstrate that updated WHO criteria for stopping mass drug administration (MDA) have been met.A cross-sectional study was conducted from September 2016 to January 2017. Participants were 5- to 9-year-old school children. Onchocerciasis/lymphatic Filariasis (LF, only in endemic districts) rapid diagnostic tests (RDTs) were performed. Blood spots were collected from RDT positive children and 10 percent of the RDT negatives to determine Ov16 and Wb123 IgG4 antibodies through enzyme-linked immunosorbent assay (ELISA). Skin snips were collected from RDT positives. Filarial detection was performed by PCR in positives and indeterminate sera. Black fly collection was carried out in traditional breeding sites. A total of 7,052 children, ranging from 5 to 9 years of age, were included in the study. Four children (0.06%) were Ov16 IgG4 RDT positives, but negative by ELISA Ov16, while 6 RDT negative children tested positive by ELISA. A total of 1,230 children from the Riaba and Baney districts were tested for LF. One child was Wb123 RDT positive (0.08%), but ELISA negative, while 3 RDT negative children were positive by Wb123 ELISA. All positive samples were negative by PCR for onchocerciasis and LF (in blood spot and skin snip). All fly collections and larval prospections in the traditional catching and prospection sites were negative.WHO criteria have been met, therefore MDA in Bioko Island can be stopped. Three years of post-treatment surveillance should be implemented to identify any new occurrences of exposure or infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 5 e0006471 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Zaida Herrador Belén Garcia Policarpo Ncogo Maria Jesus Perteguer Jose Miguel Rubio Eva Rivas Marta Cimas Guillermo Ordoñez Silvia de Pablos Ana Hernández-González Rufino Nguema Laura Moya María Romay-Barja Teresa Garate Kira Barbre Agustín Benito Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Onchocerciasis, also known as river blindness, is a parasitic disease. More than 99 percent of all cases occur in Africa. Bioko Island (Equatorial Guinea) is the only island endemic for onchocerciasis in the world. Since 2005, when vector Simulium yahense was eliminated, there have not been any reported cases of infection. This study aimed to demonstrate that updated WHO criteria for stopping mass drug administration (MDA) have been met.A cross-sectional study was conducted from September 2016 to January 2017. Participants were 5- to 9-year-old school children. Onchocerciasis/lymphatic Filariasis (LF, only in endemic districts) rapid diagnostic tests (RDTs) were performed. Blood spots were collected from RDT positive children and 10 percent of the RDT negatives to determine Ov16 and Wb123 IgG4 antibodies through enzyme-linked immunosorbent assay (ELISA). Skin snips were collected from RDT positives. Filarial detection was performed by PCR in positives and indeterminate sera. Black fly collection was carried out in traditional breeding sites. A total of 7,052 children, ranging from 5 to 9 years of age, were included in the study. Four children (0.06%) were Ov16 IgG4 RDT positives, but negative by ELISA Ov16, while 6 RDT negative children tested positive by ELISA. A total of 1,230 children from the Riaba and Baney districts were tested for LF. One child was Wb123 RDT positive (0.08%), but ELISA negative, while 3 RDT negative children were positive by Wb123 ELISA. All positive samples were negative by PCR for onchocerciasis and LF (in blood spot and skin snip). All fly collections and larval prospections in the traditional catching and prospection sites were negative.WHO criteria have been met, therefore MDA in Bioko Island can be stopped. Three years of post-treatment surveillance should be implemented to identify any new occurrences of exposure or infection. |
format |
Article in Journal/Newspaper |
author |
Zaida Herrador Belén Garcia Policarpo Ncogo Maria Jesus Perteguer Jose Miguel Rubio Eva Rivas Marta Cimas Guillermo Ordoñez Silvia de Pablos Ana Hernández-González Rufino Nguema Laura Moya María Romay-Barja Teresa Garate Kira Barbre Agustín Benito |
author_facet |
Zaida Herrador Belén Garcia Policarpo Ncogo Maria Jesus Perteguer Jose Miguel Rubio Eva Rivas Marta Cimas Guillermo Ordoñez Silvia de Pablos Ana Hernández-González Rufino Nguema Laura Moya María Romay-Barja Teresa Garate Kira Barbre Agustín Benito |
author_sort |
Zaida Herrador |
title |
Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea. |
title_short |
Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea. |
title_full |
Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea. |
title_fullStr |
Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea. |
title_full_unstemmed |
Interruption of onchocerciasis transmission in Bioko Island: Accelerating the movement from control to elimination in Equatorial Guinea. |
title_sort |
interruption of onchocerciasis transmission in bioko island: accelerating the movement from control to elimination in equatorial guinea. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006471 https://doaj.org/article/0a9fd848edd544039781c1ab7eec2b2f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006471 (2018) |
op_relation |
http://europepmc.org/articles/PMC5953477?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006471 https://doaj.org/article/0a9fd848edd544039781c1ab7eec2b2f |
op_doi |
https://doi.org/10.1371/journal.pntd.0006471 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
5 |
container_start_page |
e0006471 |
_version_ |
1766345332516454400 |