COVID-19 and newborn health: systematic review
Objective. To describe perinatal and neonatal outcomes in newborns exposed to SARS-CoV-2. Methods. A systematic review was conducted by searching PubMed Central, LILACS, and Google Scholar using the keywords ‘covid’ AND ‘newborn’ OR ‘child’ OR ‘infant,’ on 18 March 2020, and again on 17 April 2020....
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ftdoajarticles:oai:doaj.org/article:0a837fa17be44472bc1dec771820ff42 2023-05-15T15:16:52+02:00 COVID-19 and newborn health: systematic review Pablo Duran Stephen Berman Susan Niermeyer Thomas Jaenisch Thais Forster Rodolfo Gomez Ponce de Leon Bremen De Mucio Suzanne Serruya 2020-04-01T00:00:00Z https://doi.org/10.26633/RPSP.2020.54 https://doaj.org/article/0a837fa17be44472bc1dec771820ff42 EN ES PT eng spa por Pan American Health Organization https://iris.paho.org/handle/10665.2/52039 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 doi:10.26633/RPSP.2020.54 https://doaj.org/article/0a837fa17be44472bc1dec771820ff42 Revista Panamericana de Salud Pública, Vol 44, Iss 54, Pp 1-12 (2020) coronavirus infection virus diseases pandemics sars virus congenital hereditary and neonatal diseases and abnormalities infectious disease transmission vertical Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.26633/RPSP.2020.54 2022-12-31T09:23:06Z Objective. To describe perinatal and neonatal outcomes in newborns exposed to SARS-CoV-2. Methods. A systematic review was conducted by searching PubMed Central, LILACS, and Google Scholar using the keywords ‘covid’ AND ‘newborn’ OR ‘child’ OR ‘infant,’ on 18 March 2020, and again on 17 April 2020. One researcher conducted the search and extracted data on demographics, maternal outcomes, diagnostic tests, imaging, and neonatal outcomes. Results. Of 256 publications identified, 20 met inclusion criteria and comprised neonatal outcome data for 222 newborns whose mothers were suspected or confirmed to be SARS-CoV-2 positive perinatally (17 studies) or of newborns referred to hospital with infection/pneumonia (3 studies). Most (12 studies) were case-series reports; all were from China, except three (Australia, Iran, and Spain). Of the 222 newborns, 13 were reported as positive for SARS-CoV-2; most of the studies reported no or mild symptoms and no adverse perinatal outcomes. Two papers among those from newborns who tested positive reported moderate or severe clinical characteristics. Five studies using data on umbilical cord blood, placenta, and/or amniotic fluid reported no positive results. Nine studies reported radiographic imaging, including 5 with images of pneumonia, increased lung marking, thickened texture, or high-density nodular shadow. Minor, non-specific changes in biochemical variables were reported. Studies that tested breast milk reported negative SARS-CoV-2 results. Conclusions. Given the paucity of studies at this time, vertical transmission cannot be confirmed or denied. Current literature does not support abstaining from breastfeeding nor separating mothers and newborns. Further evidence and data collection networks, particularly in the Americas, are needed for establishing definitive guidelines and recommendations. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista Panamericana de Salud Pública 44 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
coronavirus infection virus diseases pandemics sars virus congenital hereditary and neonatal diseases and abnormalities infectious disease transmission vertical Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
coronavirus infection virus diseases pandemics sars virus congenital hereditary and neonatal diseases and abnormalities infectious disease transmission vertical Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Pablo Duran Stephen Berman Susan Niermeyer Thomas Jaenisch Thais Forster Rodolfo Gomez Ponce de Leon Bremen De Mucio Suzanne Serruya COVID-19 and newborn health: systematic review |
topic_facet |
coronavirus infection virus diseases pandemics sars virus congenital hereditary and neonatal diseases and abnormalities infectious disease transmission vertical Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Objective. To describe perinatal and neonatal outcomes in newborns exposed to SARS-CoV-2. Methods. A systematic review was conducted by searching PubMed Central, LILACS, and Google Scholar using the keywords ‘covid’ AND ‘newborn’ OR ‘child’ OR ‘infant,’ on 18 March 2020, and again on 17 April 2020. One researcher conducted the search and extracted data on demographics, maternal outcomes, diagnostic tests, imaging, and neonatal outcomes. Results. Of 256 publications identified, 20 met inclusion criteria and comprised neonatal outcome data for 222 newborns whose mothers were suspected or confirmed to be SARS-CoV-2 positive perinatally (17 studies) or of newborns referred to hospital with infection/pneumonia (3 studies). Most (12 studies) were case-series reports; all were from China, except three (Australia, Iran, and Spain). Of the 222 newborns, 13 were reported as positive for SARS-CoV-2; most of the studies reported no or mild symptoms and no adverse perinatal outcomes. Two papers among those from newborns who tested positive reported moderate or severe clinical characteristics. Five studies using data on umbilical cord blood, placenta, and/or amniotic fluid reported no positive results. Nine studies reported radiographic imaging, including 5 with images of pneumonia, increased lung marking, thickened texture, or high-density nodular shadow. Minor, non-specific changes in biochemical variables were reported. Studies that tested breast milk reported negative SARS-CoV-2 results. Conclusions. Given the paucity of studies at this time, vertical transmission cannot be confirmed or denied. Current literature does not support abstaining from breastfeeding nor separating mothers and newborns. Further evidence and data collection networks, particularly in the Americas, are needed for establishing definitive guidelines and recommendations. |
format |
Article in Journal/Newspaper |
author |
Pablo Duran Stephen Berman Susan Niermeyer Thomas Jaenisch Thais Forster Rodolfo Gomez Ponce de Leon Bremen De Mucio Suzanne Serruya |
author_facet |
Pablo Duran Stephen Berman Susan Niermeyer Thomas Jaenisch Thais Forster Rodolfo Gomez Ponce de Leon Bremen De Mucio Suzanne Serruya |
author_sort |
Pablo Duran |
title |
COVID-19 and newborn health: systematic review |
title_short |
COVID-19 and newborn health: systematic review |
title_full |
COVID-19 and newborn health: systematic review |
title_fullStr |
COVID-19 and newborn health: systematic review |
title_full_unstemmed |
COVID-19 and newborn health: systematic review |
title_sort |
covid-19 and newborn health: systematic review |
publisher |
Pan American Health Organization |
publishDate |
2020 |
url |
https://doi.org/10.26633/RPSP.2020.54 https://doaj.org/article/0a837fa17be44472bc1dec771820ff42 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 44, Iss 54, Pp 1-12 (2020) |
op_relation |
https://iris.paho.org/handle/10665.2/52039 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 doi:10.26633/RPSP.2020.54 https://doaj.org/article/0a837fa17be44472bc1dec771820ff42 |
op_doi |
https://doi.org/10.26633/RPSP.2020.54 |
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Revista Panamericana de Salud Pública |
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44 |
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