PREVALENCE OF HEPATITIS B AND HEPATITIS C MARKERS IN ALCOHOLICS WITH AND WITHOUT CLINICALLY EVIDENT HEPATIC CIRRHOSIS
We assessed the frequency of serological markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in 365 alcoholics by determining, by ELISA, the presence of HBsAg, anti-HBc, anti-HBs and anti-HCV. Fifty patients were cirrhotics and 315 had no evidence of hepatic cirrhosis; of the l...
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Universidade de São Paulo (USP)
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ftdoajarticles:oai:doaj.org/article:0a50420341784ecba05eb2c499ceecca 2024-09-09T19:27:28+00:00 PREVALENCE OF HEPATITIS B AND HEPATITIS C MARKERS IN ALCOHOLICS WITH AND WITHOUT CLINICALLY EVIDENT HEPATIC CIRRHOSIS OLIVEIRA Luiz Carlos Marques de BUSO Abadia Gilda OLIVEIRA Alessandra Terezinha Rodrigues de ARANTES Cidamaiá Aparecida BORGES Luciana Vasconcelos VALENTE Selma Regina Guerra 1999-01-01T00:00:00Z https://doaj.org/article/0a50420341784ecba05eb2c499ceecca EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651999000200002 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/0a50420341784ecba05eb2c499ceecca Revista do Instituto de Medicina Tropical de São Paulo, Vol 41, Iss 2, Pp 69-73 (1999) Hepatitis B virus Hepatitis C virus Alcoholism Alcoholic liver disease Alcoholic cirrhosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1999 ftdoajarticles 2024-08-05T17:49:30Z We assessed the frequency of serological markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in 365 alcoholics by determining, by ELISA, the presence of HBsAg, anti-HBc, anti-HBs and anti-HCV. Fifty patients were cirrhotics and 315 had no evidence of hepatic cirrhosis; of the latter HBsAg was assessed in all, anti-HBc and anti-HBs in 130, and anti-HCV in 210. Among the alcoholics the frequencies of HBsAg (1.9%), anti-HBc (28.3%) and anti-HCV (3.8%) were higher (p<0.001) than among the controls (N=17,059), 0.4%, 4.0% and 0.4% respectively. The frequency of positive HBsAg was higher (p<0.001) in the cirrhotic patients (8.0%) than in alcoholics without cirrhosis (0.95%) and in controls (0.4%), and similar between the latter; of anti-HBc in alcoholics without cirrhosis (28.5%) was similar in cirrhotics patients (28.0%) and higher (p<0.001) than in the controls (4.0%); of anti-HBs in alcoholics without cirrhosis (20.8%) was similar to that of the cirrhotic patients (10.0%), and the anti-HCV was similar between alcoholics with (6.0%) and without cirrhosis (3.3%) and higher (p<0.001) than in controls (0.4%). We concluded that: a) alcoholics with or without cirrhosis have similar frequencies of infection with HBV and HCV between them, and higher than in nonalcoholics; b) alcoholics without cirrhosis had a frequency of HBV active infection (HBsAg+) which was similar to the controls, whereas among those who progressed to cirrhosis this frequency was significantly higher, what suggests that HBV may be implicated in the pathogenesis of cirrhosis in a few alcoholic individuals. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Hepatitis B virus Hepatitis C virus Alcoholism Alcoholic liver disease Alcoholic cirrhosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Hepatitis B virus Hepatitis C virus Alcoholism Alcoholic liver disease Alcoholic cirrhosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 OLIVEIRA Luiz Carlos Marques de BUSO Abadia Gilda OLIVEIRA Alessandra Terezinha Rodrigues de ARANTES Cidamaiá Aparecida BORGES Luciana Vasconcelos VALENTE Selma Regina Guerra PREVALENCE OF HEPATITIS B AND HEPATITIS C MARKERS IN ALCOHOLICS WITH AND WITHOUT CLINICALLY EVIDENT HEPATIC CIRRHOSIS |
topic_facet |
Hepatitis B virus Hepatitis C virus Alcoholism Alcoholic liver disease Alcoholic cirrhosis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
We assessed the frequency of serological markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in 365 alcoholics by determining, by ELISA, the presence of HBsAg, anti-HBc, anti-HBs and anti-HCV. Fifty patients were cirrhotics and 315 had no evidence of hepatic cirrhosis; of the latter HBsAg was assessed in all, anti-HBc and anti-HBs in 130, and anti-HCV in 210. Among the alcoholics the frequencies of HBsAg (1.9%), anti-HBc (28.3%) and anti-HCV (3.8%) were higher (p<0.001) than among the controls (N=17,059), 0.4%, 4.0% and 0.4% respectively. The frequency of positive HBsAg was higher (p<0.001) in the cirrhotic patients (8.0%) than in alcoholics without cirrhosis (0.95%) and in controls (0.4%), and similar between the latter; of anti-HBc in alcoholics without cirrhosis (28.5%) was similar in cirrhotics patients (28.0%) and higher (p<0.001) than in the controls (4.0%); of anti-HBs in alcoholics without cirrhosis (20.8%) was similar to that of the cirrhotic patients (10.0%), and the anti-HCV was similar between alcoholics with (6.0%) and without cirrhosis (3.3%) and higher (p<0.001) than in controls (0.4%). We concluded that: a) alcoholics with or without cirrhosis have similar frequencies of infection with HBV and HCV between them, and higher than in nonalcoholics; b) alcoholics without cirrhosis had a frequency of HBV active infection (HBsAg+) which was similar to the controls, whereas among those who progressed to cirrhosis this frequency was significantly higher, what suggests that HBV may be implicated in the pathogenesis of cirrhosis in a few alcoholic individuals. |
format |
Article in Journal/Newspaper |
author |
OLIVEIRA Luiz Carlos Marques de BUSO Abadia Gilda OLIVEIRA Alessandra Terezinha Rodrigues de ARANTES Cidamaiá Aparecida BORGES Luciana Vasconcelos VALENTE Selma Regina Guerra |
author_facet |
OLIVEIRA Luiz Carlos Marques de BUSO Abadia Gilda OLIVEIRA Alessandra Terezinha Rodrigues de ARANTES Cidamaiá Aparecida BORGES Luciana Vasconcelos VALENTE Selma Regina Guerra |
author_sort |
OLIVEIRA Luiz Carlos Marques de |
title |
PREVALENCE OF HEPATITIS B AND HEPATITIS C MARKERS IN ALCOHOLICS WITH AND WITHOUT CLINICALLY EVIDENT HEPATIC CIRRHOSIS |
title_short |
PREVALENCE OF HEPATITIS B AND HEPATITIS C MARKERS IN ALCOHOLICS WITH AND WITHOUT CLINICALLY EVIDENT HEPATIC CIRRHOSIS |
title_full |
PREVALENCE OF HEPATITIS B AND HEPATITIS C MARKERS IN ALCOHOLICS WITH AND WITHOUT CLINICALLY EVIDENT HEPATIC CIRRHOSIS |
title_fullStr |
PREVALENCE OF HEPATITIS B AND HEPATITIS C MARKERS IN ALCOHOLICS WITH AND WITHOUT CLINICALLY EVIDENT HEPATIC CIRRHOSIS |
title_full_unstemmed |
PREVALENCE OF HEPATITIS B AND HEPATITIS C MARKERS IN ALCOHOLICS WITH AND WITHOUT CLINICALLY EVIDENT HEPATIC CIRRHOSIS |
title_sort |
prevalence of hepatitis b and hepatitis c markers in alcoholics with and without clinically evident hepatic cirrhosis |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1999 |
url |
https://doaj.org/article/0a50420341784ecba05eb2c499ceecca |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 41, Iss 2, Pp 69-73 (1999) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651999000200002 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/0a50420341784ecba05eb2c499ceecca |
_version_ |
1809896891989622784 |