Association of ADAMTS13 polymorphism with cerebral malaria
Abstract Background Cerebral malaria is one of the most severe manifestations of Plasmodium falciparum malaria. The sequestration of parasitized red blood cells (PRBCs) to brain microvascular endothelium has been shown to contribute to the pathophysiology of cerebral malaria. Recent studies reported...
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ftdoajarticles:oai:doaj.org/article:0a4586cdc8d44df691bf4cb88168e479 2023-05-15T15:10:00+02:00 Association of ADAMTS13 polymorphism with cerebral malaria Kraisin Sirima Naka Izumi Patarapotikul Jintana Nantakomol Duangdao Nuchnoi Pornlada Hananantachai Hathairad Tsuchiya Naoyuki Ohashi Jun 2011-12-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-366 https://doaj.org/article/0a4586cdc8d44df691bf4cb88168e479 EN eng BMC http://www.malariajournal.com/content/10/1/366 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-366 1475-2875 https://doaj.org/article/0a4586cdc8d44df691bf4cb88168e479 Malaria Journal, Vol 10, Iss 1, p 366 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-366 2022-12-31T08:51:07Z Abstract Background Cerebral malaria is one of the most severe manifestations of Plasmodium falciparum malaria. The sequestration of parasitized red blood cells (PRBCs) to brain microvascular endothelium has been shown to contribute to the pathophysiology of cerebral malaria. Recent studies reported increased levels of von Willebrand factor (VWF) and reduced activity of VWF-cleaving protease, ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), in patients with cerebral malaria. Methods Association of six single nucleotide polymorphisms (SNPs) of the ADAMTS13 gene with cerebral malaria was examined in 708 Thai patients with P. falciparum malaria. Results Among six SNPs, the derived allele of a SNP located in intron 28, rs4962153-A, was significantly associated with protection against cerebral malaria when 115 cerebral malaria patients were compared with 367 mild malaria patients (Fisher's exact P -value = 0.0057; OR = 0.27; 95% CI = 0.096-0.76). Significant association was also detected between 115 cerebral malaria and 593 non-cerebral malaria (226 non-cerebral severe malaria and 367 mild malaria) patients (Fisher's exact P -value = 0.012; OR = 0.30; 95% CI = 0.11-0.83). Conclusions Excessive adhesion of PRBCs to the platelet-decorated ultra-large VWF (ULVWF) appears to enhance the sequestration of PRBCs to cerebral microvascular endothelium. The genetic association observed in the present study implies that the regulation of platelet-decorated ULVWF strings by ADAMTS13 may play a role in the development of cerebral malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 366 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kraisin Sirima Naka Izumi Patarapotikul Jintana Nantakomol Duangdao Nuchnoi Pornlada Hananantachai Hathairad Tsuchiya Naoyuki Ohashi Jun Association of ADAMTS13 polymorphism with cerebral malaria |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Cerebral malaria is one of the most severe manifestations of Plasmodium falciparum malaria. The sequestration of parasitized red blood cells (PRBCs) to brain microvascular endothelium has been shown to contribute to the pathophysiology of cerebral malaria. Recent studies reported increased levels of von Willebrand factor (VWF) and reduced activity of VWF-cleaving protease, ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), in patients with cerebral malaria. Methods Association of six single nucleotide polymorphisms (SNPs) of the ADAMTS13 gene with cerebral malaria was examined in 708 Thai patients with P. falciparum malaria. Results Among six SNPs, the derived allele of a SNP located in intron 28, rs4962153-A, was significantly associated with protection against cerebral malaria when 115 cerebral malaria patients were compared with 367 mild malaria patients (Fisher's exact P -value = 0.0057; OR = 0.27; 95% CI = 0.096-0.76). Significant association was also detected between 115 cerebral malaria and 593 non-cerebral malaria (226 non-cerebral severe malaria and 367 mild malaria) patients (Fisher's exact P -value = 0.012; OR = 0.30; 95% CI = 0.11-0.83). Conclusions Excessive adhesion of PRBCs to the platelet-decorated ultra-large VWF (ULVWF) appears to enhance the sequestration of PRBCs to cerebral microvascular endothelium. The genetic association observed in the present study implies that the regulation of platelet-decorated ULVWF strings by ADAMTS13 may play a role in the development of cerebral malaria. |
format |
Article in Journal/Newspaper |
author |
Kraisin Sirima Naka Izumi Patarapotikul Jintana Nantakomol Duangdao Nuchnoi Pornlada Hananantachai Hathairad Tsuchiya Naoyuki Ohashi Jun |
author_facet |
Kraisin Sirima Naka Izumi Patarapotikul Jintana Nantakomol Duangdao Nuchnoi Pornlada Hananantachai Hathairad Tsuchiya Naoyuki Ohashi Jun |
author_sort |
Kraisin Sirima |
title |
Association of ADAMTS13 polymorphism with cerebral malaria |
title_short |
Association of ADAMTS13 polymorphism with cerebral malaria |
title_full |
Association of ADAMTS13 polymorphism with cerebral malaria |
title_fullStr |
Association of ADAMTS13 polymorphism with cerebral malaria |
title_full_unstemmed |
Association of ADAMTS13 polymorphism with cerebral malaria |
title_sort |
association of adamts13 polymorphism with cerebral malaria |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-366 https://doaj.org/article/0a4586cdc8d44df691bf4cb88168e479 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 366 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/366 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-366 1475-2875 https://doaj.org/article/0a4586cdc8d44df691bf4cb88168e479 |
op_doi |
https://doi.org/10.1186/1475-2875-10-366 |
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Malaria Journal |
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10 |
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1 |
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366 |
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1766341077762048000 |