Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American.
Toxocara canis and T. cati are parasites of dogs and cats, respectively, that infect humans and cause human toxocariasis. Infection may cause asthma-like symptoms but is often asymptomatic and is associated with a marked eosinophilia. Previous epidemiological studies indicate that T. canis infection...
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ftdoajarticles:oai:doaj.org/article:0a090ad41ca04d48aafbede487a7731f 2023-05-15T15:13:11+02:00 Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. Lívia Ribeiro Mendonça Rafael Valente Veiga Vitor Camilo Cavalcante Dattoli Camila Alexandrina Figueiredo Rosemeire Fiaccone Jackson Santos Álvaro Augusto Cruz Laura Cunha Rodrigues Philip John Cooper Lain Carlos Pontes-de-Carvalho Maurício Lima Barreto Neuza Maria Alcantara-Neves 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001886 https://doaj.org/article/0a090ad41ca04d48aafbede487a7731f EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3486906?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001886 https://doaj.org/article/0a090ad41ca04d48aafbede487a7731f PLoS Neglected Tropical Diseases, Vol 6, Iss 11, p e1886 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001886 2023-01-08T01:26:58Z Toxocara canis and T. cati are parasites of dogs and cats, respectively, that infect humans and cause human toxocariasis. Infection may cause asthma-like symptoms but is often asymptomatic and is associated with a marked eosinophilia. Previous epidemiological studies indicate that T. canis infection may be associated with the development of atopy and asthma.To investigate possible associations between Toxocara spp. seropositivity and atopy and childhood wheezing in a population of children living in non-affluent areas of a large Latin American city.The study was conducted in the city of Salvador, Brazil. Data on wheezing symptoms were collected by questionnaire, and atopy was measured by the presence of aeroallergen-specific IgE (sIgE). Skin prick test (SPT), total IgE and peripheral eosinophilia were measured. Toxocara seropositivity was determined by the presence of anti-Toxocara IgG antibodies, and intestinal helminth infections were determined by stool microscopy.Children aged 4 to 11 years were studied, of whom 47% were seropositive for anti-Toxocara IgG; eosinophilia >4% occurred in 74.2% and >10% in 25.4%; 59.6% had elevated levels of total IgE; 36.8% had sIgE≥0.70 kU/L and 30.4% had SPT for at least one aeroallergen; 22.4% had current wheezing symptoms. Anti-Toxocara IgG was positively associated with elevated eosinophils counts, total IgE and the presence of specific IgE to aeroallergens but was inversely associated with skin prick test reactivity.The prevalence of Toxocara seropositivity was high in the studied population of children living in conditions of poverty in urban Brazil. Toxocara infection, although associated with total IgE, sIgE and eosinophilia, may prevent the development of skin hypersensitivity to aeroallergens, possibly through increased polyclonal IgE and the induction of a modified Th2 immune reaction. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 11 e1886 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Lívia Ribeiro Mendonça Rafael Valente Veiga Vitor Camilo Cavalcante Dattoli Camila Alexandrina Figueiredo Rosemeire Fiaccone Jackson Santos Álvaro Augusto Cruz Laura Cunha Rodrigues Philip John Cooper Lain Carlos Pontes-de-Carvalho Maurício Lima Barreto Neuza Maria Alcantara-Neves Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Toxocara canis and T. cati are parasites of dogs and cats, respectively, that infect humans and cause human toxocariasis. Infection may cause asthma-like symptoms but is often asymptomatic and is associated with a marked eosinophilia. Previous epidemiological studies indicate that T. canis infection may be associated with the development of atopy and asthma.To investigate possible associations between Toxocara spp. seropositivity and atopy and childhood wheezing in a population of children living in non-affluent areas of a large Latin American city.The study was conducted in the city of Salvador, Brazil. Data on wheezing symptoms were collected by questionnaire, and atopy was measured by the presence of aeroallergen-specific IgE (sIgE). Skin prick test (SPT), total IgE and peripheral eosinophilia were measured. Toxocara seropositivity was determined by the presence of anti-Toxocara IgG antibodies, and intestinal helminth infections were determined by stool microscopy.Children aged 4 to 11 years were studied, of whom 47% were seropositive for anti-Toxocara IgG; eosinophilia >4% occurred in 74.2% and >10% in 25.4%; 59.6% had elevated levels of total IgE; 36.8% had sIgE≥0.70 kU/L and 30.4% had SPT for at least one aeroallergen; 22.4% had current wheezing symptoms. Anti-Toxocara IgG was positively associated with elevated eosinophils counts, total IgE and the presence of specific IgE to aeroallergens but was inversely associated with skin prick test reactivity.The prevalence of Toxocara seropositivity was high in the studied population of children living in conditions of poverty in urban Brazil. Toxocara infection, although associated with total IgE, sIgE and eosinophilia, may prevent the development of skin hypersensitivity to aeroallergens, possibly through increased polyclonal IgE and the induction of a modified Th2 immune reaction. |
format |
Article in Journal/Newspaper |
author |
Lívia Ribeiro Mendonça Rafael Valente Veiga Vitor Camilo Cavalcante Dattoli Camila Alexandrina Figueiredo Rosemeire Fiaccone Jackson Santos Álvaro Augusto Cruz Laura Cunha Rodrigues Philip John Cooper Lain Carlos Pontes-de-Carvalho Maurício Lima Barreto Neuza Maria Alcantara-Neves |
author_facet |
Lívia Ribeiro Mendonça Rafael Valente Veiga Vitor Camilo Cavalcante Dattoli Camila Alexandrina Figueiredo Rosemeire Fiaccone Jackson Santos Álvaro Augusto Cruz Laura Cunha Rodrigues Philip John Cooper Lain Carlos Pontes-de-Carvalho Maurício Lima Barreto Neuza Maria Alcantara-Neves |
author_sort |
Lívia Ribeiro Mendonça |
title |
Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. |
title_short |
Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. |
title_full |
Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. |
title_fullStr |
Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. |
title_full_unstemmed |
Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. |
title_sort |
toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban latin american. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001886 https://doaj.org/article/0a090ad41ca04d48aafbede487a7731f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 11, p e1886 (2012) |
op_relation |
http://europepmc.org/articles/PMC3486906?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001886 https://doaj.org/article/0a090ad41ca04d48aafbede487a7731f |
op_doi |
https://doi.org/10.1371/journal.pntd.0001886 |
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PLoS Neglected Tropical Diseases |
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6 |
container_issue |
11 |
container_start_page |
e1886 |
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