Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study.
Background Cryptococcosis is a neglected and predominantly opportunistic mycosis that, in Brazil, poses an important public health problem, due to its late diagnosis and high lethality. Methods The present study analysed cryptococcosis mortality in Brazil from January 2000 to December 2012, based on...
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ftdoajarticles:oai:doaj.org/article:09d967fe739c478ea7bb188de7619b5f 2023-05-15T15:13:24+02:00 Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study. Emmanuel Alves Soares Márcia Dos Santos Lazera Bodo Wanke Marcela de Faria Ferreira Raquel Vasconcellos Carvalhaes de Oliveira Adeno Gonçalves Oliveira Ziadir Francisco Coutinho 2019-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007569 https://doaj.org/article/09d967fe739c478ea7bb188de7619b5f EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007569 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007569 https://doaj.org/article/09d967fe739c478ea7bb188de7619b5f PLoS Neglected Tropical Diseases, Vol 13, Iss 7, p e0007569 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007569 2022-12-31T07:16:57Z Background Cryptococcosis is a neglected and predominantly opportunistic mycosis that, in Brazil, poses an important public health problem, due to its late diagnosis and high lethality. Methods The present study analysed cryptococcosis mortality in Brazil from January 2000 to December 2012, based on secondary data (Mortality Information System/SIM-DATASUS and IBGE). Results Out of 5,755 recorded deaths in which cryptococcosis was mentioned as one of the morbid states that contributed to death, two distinct groups emerged: 1,121 (19.5%) registered cryptococcosis as the basic cause of death, and 4,634 (80.5%) registered cryptococcosis associated with risk factors, mainly AIDS (75%), followed by other host risks (5.5%). The mortality rate by cryptococcosis as the basic cause was 6.19/million inhabitants, whereas the mortality rate by cryptococcosis as an associated cause was 25.19/million inhabitants. Meningitis was the predominant clinical form (80%), males were the more affected (69%), and 39.5 years old was the mean age. The highest mortality rate due to cryptococcosis as basic cause occurred in the state of Mato Grosso (10.96/million inhabitants). Mortality rates due to cryptococcosis as associated cause were highest in the states of Santa Catarina (70.41/million inhabitants) and Rio Grande do Sul (64.40/million inhabitants), both in the South Region. Southeast, Northeast and South showed significant time trends in mortality rates. Conclusions This study is relevant because it shows the magnitude of cryptococcosis mortality linked to AIDS and removes the invisibility of a particular non-AIDS-related disease, accounting for almost 20% of all cryptococcosis deaths. It can also contribute to control and surveillance programs, beyond highlighting the urgent prioritization of early diagnosis and proper treatment to reduce the unacceptable mortality rate of this neglected mycosis in Brazil. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 7 e0007569 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Emmanuel Alves Soares Márcia Dos Santos Lazera Bodo Wanke Marcela de Faria Ferreira Raquel Vasconcellos Carvalhaes de Oliveira Adeno Gonçalves Oliveira Ziadir Francisco Coutinho Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Cryptococcosis is a neglected and predominantly opportunistic mycosis that, in Brazil, poses an important public health problem, due to its late diagnosis and high lethality. Methods The present study analysed cryptococcosis mortality in Brazil from January 2000 to December 2012, based on secondary data (Mortality Information System/SIM-DATASUS and IBGE). Results Out of 5,755 recorded deaths in which cryptococcosis was mentioned as one of the morbid states that contributed to death, two distinct groups emerged: 1,121 (19.5%) registered cryptococcosis as the basic cause of death, and 4,634 (80.5%) registered cryptococcosis associated with risk factors, mainly AIDS (75%), followed by other host risks (5.5%). The mortality rate by cryptococcosis as the basic cause was 6.19/million inhabitants, whereas the mortality rate by cryptococcosis as an associated cause was 25.19/million inhabitants. Meningitis was the predominant clinical form (80%), males were the more affected (69%), and 39.5 years old was the mean age. The highest mortality rate due to cryptococcosis as basic cause occurred in the state of Mato Grosso (10.96/million inhabitants). Mortality rates due to cryptococcosis as associated cause were highest in the states of Santa Catarina (70.41/million inhabitants) and Rio Grande do Sul (64.40/million inhabitants), both in the South Region. Southeast, Northeast and South showed significant time trends in mortality rates. Conclusions This study is relevant because it shows the magnitude of cryptococcosis mortality linked to AIDS and removes the invisibility of a particular non-AIDS-related disease, accounting for almost 20% of all cryptococcosis deaths. It can also contribute to control and surveillance programs, beyond highlighting the urgent prioritization of early diagnosis and proper treatment to reduce the unacceptable mortality rate of this neglected mycosis in Brazil. |
format |
Article in Journal/Newspaper |
author |
Emmanuel Alves Soares Márcia Dos Santos Lazera Bodo Wanke Marcela de Faria Ferreira Raquel Vasconcellos Carvalhaes de Oliveira Adeno Gonçalves Oliveira Ziadir Francisco Coutinho |
author_facet |
Emmanuel Alves Soares Márcia Dos Santos Lazera Bodo Wanke Marcela de Faria Ferreira Raquel Vasconcellos Carvalhaes de Oliveira Adeno Gonçalves Oliveira Ziadir Francisco Coutinho |
author_sort |
Emmanuel Alves Soares |
title |
Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study. |
title_short |
Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study. |
title_full |
Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study. |
title_fullStr |
Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study. |
title_full_unstemmed |
Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study. |
title_sort |
mortality by cryptococcosis in brazil from 2000 to 2012: a descriptive epidemiological study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007569 https://doaj.org/article/09d967fe739c478ea7bb188de7619b5f |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 7, p e0007569 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007569 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007569 https://doaj.org/article/09d967fe739c478ea7bb188de7619b5f |
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https://doi.org/10.1371/journal.pntd.0007569 |
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PLOS Neglected Tropical Diseases |
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e0007569 |
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