Associations between Vitamin D Status and Type 2 Diabetes Measures among Inuit in Greenland May Be Affected by Other Factors.
OBJECTIVE:Epidemiological studies have provided evidence of an association between vitamin D insufficiency and type 2 diabetes. Vitamin D levels have decreased among Inuit in Greenland, and type 2 diabetes is increasing. We hypothesized that the decline in vitamin D could have contributed to the inc...
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ftdoajarticles:oai:doaj.org/article:099f4b6b83d44ecc8669bfbda9b2127d 2023-05-15T16:28:29+02:00 Associations between Vitamin D Status and Type 2 Diabetes Measures among Inuit in Greenland May Be Affected by Other Factors. Nina O Nielsen Peter Bjerregaard Pernille F Rønn Henrik Friis Stig Andersen Mads Melbye Marika Lundqvist Arieh S Cohen David M Hougaard Marit E Jørgensen 2016-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0152763 https://doaj.org/article/099f4b6b83d44ecc8669bfbda9b2127d EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4830590?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0152763 https://doaj.org/article/099f4b6b83d44ecc8669bfbda9b2127d PLoS ONE, Vol 11, Iss 4, p e0152763 (2016) Medicine R Science Q article 2016 ftdoajarticles https://doi.org/10.1371/journal.pone.0152763 2022-12-30T22:00:11Z OBJECTIVE:Epidemiological studies have provided evidence of an association between vitamin D insufficiency and type 2 diabetes. Vitamin D levels have decreased among Inuit in Greenland, and type 2 diabetes is increasing. We hypothesized that the decline in vitamin D could have contributed to the increase in type 2 diabetes, and therefore investigated associations between serum 25(OH)D3 as a measure of vitamin D status and glucose homeostasis and glucose intolerance in an adult Inuit population. METHODS:2877 Inuit (≥18 years) randomly selected for participation in the Inuit Health in Transition study were included. Fasting- and 2hour plasma glucose and insulin, C-peptide and HbA1c were measured, and associations with serum 25(OH)D3 were analysed using linear and logistic regression. A subsample of 330 individuals who also donated a blood sample in 1987, were furthermore included. RESULTS:After adjustment, increasing serum 25(OH)D3 (per 10 nmol/L) was associated with higher fasting plasma glucose (0.02 mmol/L, p = 0.004), 2hour plasma glucose (0.05 nmol/L, p = 0.002) and HbA1c (0.39%, p<0.001), and with lower beta-cell function (-1.00 mmol/L, p<0.001). Serum 25(OH)D3 was positively associated with impaired fasting glycaemia (OR: 1.08, p = 0.001), but not with IGT or type 2 diabetes. CONCLUSIONS:Our results did not support an association between low vitamin D levels and risk of type 2 diabetes. Instead, we found weak positive associations between vitamin D levels and fasting- and 2hour plasma glucose levels, HbA1c and impaired fasting glycaemia, and a negative association with beta-cell function, underlining the need for determination of the causal relationship. Article in Journal/Newspaper Greenland inuit Directory of Open Access Journals: DOAJ Articles Greenland PLOS ONE 11 4 e0152763 |
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English |
topic |
Medicine R Science Q |
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Medicine R Science Q Nina O Nielsen Peter Bjerregaard Pernille F Rønn Henrik Friis Stig Andersen Mads Melbye Marika Lundqvist Arieh S Cohen David M Hougaard Marit E Jørgensen Associations between Vitamin D Status and Type 2 Diabetes Measures among Inuit in Greenland May Be Affected by Other Factors. |
topic_facet |
Medicine R Science Q |
description |
OBJECTIVE:Epidemiological studies have provided evidence of an association between vitamin D insufficiency and type 2 diabetes. Vitamin D levels have decreased among Inuit in Greenland, and type 2 diabetes is increasing. We hypothesized that the decline in vitamin D could have contributed to the increase in type 2 diabetes, and therefore investigated associations between serum 25(OH)D3 as a measure of vitamin D status and glucose homeostasis and glucose intolerance in an adult Inuit population. METHODS:2877 Inuit (≥18 years) randomly selected for participation in the Inuit Health in Transition study were included. Fasting- and 2hour plasma glucose and insulin, C-peptide and HbA1c were measured, and associations with serum 25(OH)D3 were analysed using linear and logistic regression. A subsample of 330 individuals who also donated a blood sample in 1987, were furthermore included. RESULTS:After adjustment, increasing serum 25(OH)D3 (per 10 nmol/L) was associated with higher fasting plasma glucose (0.02 mmol/L, p = 0.004), 2hour plasma glucose (0.05 nmol/L, p = 0.002) and HbA1c (0.39%, p<0.001), and with lower beta-cell function (-1.00 mmol/L, p<0.001). Serum 25(OH)D3 was positively associated with impaired fasting glycaemia (OR: 1.08, p = 0.001), but not with IGT or type 2 diabetes. CONCLUSIONS:Our results did not support an association between low vitamin D levels and risk of type 2 diabetes. Instead, we found weak positive associations between vitamin D levels and fasting- and 2hour plasma glucose levels, HbA1c and impaired fasting glycaemia, and a negative association with beta-cell function, underlining the need for determination of the causal relationship. |
format |
Article in Journal/Newspaper |
author |
Nina O Nielsen Peter Bjerregaard Pernille F Rønn Henrik Friis Stig Andersen Mads Melbye Marika Lundqvist Arieh S Cohen David M Hougaard Marit E Jørgensen |
author_facet |
Nina O Nielsen Peter Bjerregaard Pernille F Rønn Henrik Friis Stig Andersen Mads Melbye Marika Lundqvist Arieh S Cohen David M Hougaard Marit E Jørgensen |
author_sort |
Nina O Nielsen |
title |
Associations between Vitamin D Status and Type 2 Diabetes Measures among Inuit in Greenland May Be Affected by Other Factors. |
title_short |
Associations between Vitamin D Status and Type 2 Diabetes Measures among Inuit in Greenland May Be Affected by Other Factors. |
title_full |
Associations between Vitamin D Status and Type 2 Diabetes Measures among Inuit in Greenland May Be Affected by Other Factors. |
title_fullStr |
Associations between Vitamin D Status and Type 2 Diabetes Measures among Inuit in Greenland May Be Affected by Other Factors. |
title_full_unstemmed |
Associations between Vitamin D Status and Type 2 Diabetes Measures among Inuit in Greenland May Be Affected by Other Factors. |
title_sort |
associations between vitamin d status and type 2 diabetes measures among inuit in greenland may be affected by other factors. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pone.0152763 https://doaj.org/article/099f4b6b83d44ecc8669bfbda9b2127d |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_source |
PLoS ONE, Vol 11, Iss 4, p e0152763 (2016) |
op_relation |
http://europepmc.org/articles/PMC4830590?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0152763 https://doaj.org/article/099f4b6b83d44ecc8669bfbda9b2127d |
op_doi |
https://doi.org/10.1371/journal.pone.0152763 |
container_title |
PLOS ONE |
container_volume |
11 |
container_issue |
4 |
container_start_page |
e0152763 |
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1766018135806181376 |