Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia
Abstract Background In Cambodia, malaria transmission is low and most cases occur in forested areas. Sero-epidemiological techniques can be used to identify both areas of ongoing transmission and high-risk groups to be targeted by control interventions. This study utilizes repeated cross-sectional d...
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ftdoajarticles:oai:doaj.org/article:096d21f5b2444746ac8c39dfefc939f0 2023-05-15T15:17:39+02:00 Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia Cook Jackie Speybroeck Nico Sochanta Tho Somony Heng Sokny Mao Claes Filip Lemmens Kristel Theisen Michael Soares Irene S D'Alessandro Umberto Coosemans Marc Erhart Annette 2012-03-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-86 https://doaj.org/article/096d21f5b2444746ac8c39dfefc939f0 EN eng BMC http://www.malariajournal.com/content/11/1/86 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-86 1475-2875 https://doaj.org/article/096d21f5b2444746ac8c39dfefc939f0 Malaria Journal, Vol 11, Iss 1, p 86 (2012) Malaria Serology Classification and regression tree Elimination Cambodia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-86 2022-12-31T00:34:34Z Abstract Background In Cambodia, malaria transmission is low and most cases occur in forested areas. Sero-epidemiological techniques can be used to identify both areas of ongoing transmission and high-risk groups to be targeted by control interventions. This study utilizes repeated cross-sectional data to assess the risk of being malaria sero-positive at two consecutive time points during the rainy season and investigates who is most likely to sero-convert over the transmission season. Methods In 2005, two cross-sectional surveys, one in the middle and the other at the end of the malaria transmission season, were carried out in two ecologically distinct regions in Cambodia. Parasitological and serological data were collected in four districts. Antibodies to Plasmodium falciparum Glutamate Rich Protein (GLURP) and Plasmodium vivax Merozoite Surface Protein-1 19 (MSP-1 19 ) were detected using Enzyme Linked Immunosorbent Assay (ELISA). The force of infection was estimated using a simple catalytic model fitted using maximum likelihood methods. Risks for sero-converting during the rainy season were analysed using the Classification and Regression Tree (CART) method. Results A total of 804 individuals participating in both surveys were analysed. The overall parasite prevalence was low (4.6% and 2.0% for P. falciparum and 7.9% and 6.0% for P. vivax in August and November respectively). P. falciparum force of infection was higher in the eastern region and increased between August and November, whilst P. vivax force of infection was higher in the western region and remained similar in both surveys. In the western region, malaria transmission changed very little across the season (for both species). CART analysis for P. falciparum in the east highlighted age, ethnicity, village of residence and forest work as important predictors for malaria exposure during the rainy season. Adults were more likely to increase their antibody responses to P. falciparum during the transmission season than children, whilst members of the ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 |
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topic |
Malaria Serology Classification and regression tree Elimination Cambodia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Malaria Serology Classification and regression tree Elimination Cambodia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Cook Jackie Speybroeck Nico Sochanta Tho Somony Heng Sokny Mao Claes Filip Lemmens Kristel Theisen Michael Soares Irene S D'Alessandro Umberto Coosemans Marc Erhart Annette Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia |
topic_facet |
Malaria Serology Classification and regression tree Elimination Cambodia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background In Cambodia, malaria transmission is low and most cases occur in forested areas. Sero-epidemiological techniques can be used to identify both areas of ongoing transmission and high-risk groups to be targeted by control interventions. This study utilizes repeated cross-sectional data to assess the risk of being malaria sero-positive at two consecutive time points during the rainy season and investigates who is most likely to sero-convert over the transmission season. Methods In 2005, two cross-sectional surveys, one in the middle and the other at the end of the malaria transmission season, were carried out in two ecologically distinct regions in Cambodia. Parasitological and serological data were collected in four districts. Antibodies to Plasmodium falciparum Glutamate Rich Protein (GLURP) and Plasmodium vivax Merozoite Surface Protein-1 19 (MSP-1 19 ) were detected using Enzyme Linked Immunosorbent Assay (ELISA). The force of infection was estimated using a simple catalytic model fitted using maximum likelihood methods. Risks for sero-converting during the rainy season were analysed using the Classification and Regression Tree (CART) method. Results A total of 804 individuals participating in both surveys were analysed. The overall parasite prevalence was low (4.6% and 2.0% for P. falciparum and 7.9% and 6.0% for P. vivax in August and November respectively). P. falciparum force of infection was higher in the eastern region and increased between August and November, whilst P. vivax force of infection was higher in the western region and remained similar in both surveys. In the western region, malaria transmission changed very little across the season (for both species). CART analysis for P. falciparum in the east highlighted age, ethnicity, village of residence and forest work as important predictors for malaria exposure during the rainy season. Adults were more likely to increase their antibody responses to P. falciparum during the transmission season than children, whilst members of the ... |
format |
Article in Journal/Newspaper |
author |
Cook Jackie Speybroeck Nico Sochanta Tho Somony Heng Sokny Mao Claes Filip Lemmens Kristel Theisen Michael Soares Irene S D'Alessandro Umberto Coosemans Marc Erhart Annette |
author_facet |
Cook Jackie Speybroeck Nico Sochanta Tho Somony Heng Sokny Mao Claes Filip Lemmens Kristel Theisen Michael Soares Irene S D'Alessandro Umberto Coosemans Marc Erhart Annette |
author_sort |
Cook Jackie |
title |
Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia |
title_short |
Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia |
title_full |
Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia |
title_fullStr |
Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia |
title_full_unstemmed |
Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia |
title_sort |
sero-epidemiological evaluation of changes in plasmodium falciparum and plasmodium vivax transmission patterns over the rainy season in cambodia |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-86 https://doaj.org/article/096d21f5b2444746ac8c39dfefc939f0 |
geographic |
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Arctic |
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Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 86 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/86 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-86 1475-2875 https://doaj.org/article/096d21f5b2444746ac8c39dfefc939f0 |
op_doi |
https://doi.org/10.1186/1475-2875-11-86 |
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Malaria Journal |
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11 |
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1766347899423162368 |