Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels
INTRODUCTION: Approximately 30% of hepatitis C virus (HCV) monoinfected patients present persistently normal alanine aminotransferase (ALT) levels. Most of these patients have a slow progression of liver fibrosis. Studies have demonstrated the rate of liver fibrosis progression in hepatitis C virus-...
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ftdoajarticles:oai:doaj.org/article:09549bcd331f4dada8d9bcceaa7fb701 2023-05-15T15:13:08+02:00 Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels Fábio Heleno de Lima Pace Lincoln Eduardo Vieira de Castro Ferreira Antonio Eduardo Benedito Silva Maria Lucia Gomes Ferraz 2012-08-01T00:00:00Z https://doi.org/10.1590/S0037-86822012000400005 https://doaj.org/article/09549bcd331f4dada8d9bcceaa7fb701 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000400005&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822012000400005 https://doaj.org/article/09549bcd331f4dada8d9bcceaa7fb701 Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 4, Pp 444-447 (2012) Cirrose hepática Hepatite C HIV Aminotransferases Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles https://doi.org/10.1590/S0037-86822012000400005 2022-12-30T21:38:33Z INTRODUCTION: Approximately 30% of hepatitis C virus (HCV) monoinfected patients present persistently normal alanine aminotransferase (ALT) levels. Most of these patients have a slow progression of liver fibrosis. Studies have demonstrated the rate of liver fibrosis progression in hepatitis C virus-human immunodeficiency virus (HCV-HIV) coinfected patients is faster than in patients infected only by HCV. Few studies have evaluated the histological features of chronic hepatitis C in HIV-infected patients with normal ALT levels. METHODS: HCV-HIV coinfected patients (HCV-RNA and anti-HIV positive) with known time of HCV infection (intravenous drugs users) were selected. Patients with hepatitis B surface antigen (HBsAg) positive or hepatitis C treatment before liver biopsy were excluded. Patients were considered to have a normal ALT levels if they had at least 3 normal determinations in the previous 6 months prior to liver biopsy. All patients were submitted to liver biopsy and METAVIR scale was used. RESULTS: Of 50 studied patients 40 (80%) were males. All patients were treated with antiretroviral therapy. The ALT levels were normal in 13 (26%) patients. HCV-HIV co-infected patients with normal ALT levels had presented means of the liver fibrosis stages (0.77±0.44 versus 1.86±1.38; p<0.001) periportal inflammatory activity (0.62±0.77 versus 2.24±1.35; p<0.001) and liver fibrosis progression rate (0.058±0.043 fibrosis unit/year versus 0.118±0.102 fibrosis unit/year) significantly lower as compared to those with elevated ALT. CONCLUSIONS: HCV-HIV coinfected patients with persistently normal ALTs showed slower progression of liver fibrosis. In these patients the development of liver cirrhosis is improbable. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 45 4 444 447 |
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Directory of Open Access Journals: DOAJ Articles |
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Cirrose hepática Hepatite C HIV Aminotransferases Arctic medicine. Tropical medicine RC955-962 |
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Cirrose hepática Hepatite C HIV Aminotransferases Arctic medicine. Tropical medicine RC955-962 Fábio Heleno de Lima Pace Lincoln Eduardo Vieira de Castro Ferreira Antonio Eduardo Benedito Silva Maria Lucia Gomes Ferraz Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels |
topic_facet |
Cirrose hepática Hepatite C HIV Aminotransferases Arctic medicine. Tropical medicine RC955-962 |
description |
INTRODUCTION: Approximately 30% of hepatitis C virus (HCV) monoinfected patients present persistently normal alanine aminotransferase (ALT) levels. Most of these patients have a slow progression of liver fibrosis. Studies have demonstrated the rate of liver fibrosis progression in hepatitis C virus-human immunodeficiency virus (HCV-HIV) coinfected patients is faster than in patients infected only by HCV. Few studies have evaluated the histological features of chronic hepatitis C in HIV-infected patients with normal ALT levels. METHODS: HCV-HIV coinfected patients (HCV-RNA and anti-HIV positive) with known time of HCV infection (intravenous drugs users) were selected. Patients with hepatitis B surface antigen (HBsAg) positive or hepatitis C treatment before liver biopsy were excluded. Patients were considered to have a normal ALT levels if they had at least 3 normal determinations in the previous 6 months prior to liver biopsy. All patients were submitted to liver biopsy and METAVIR scale was used. RESULTS: Of 50 studied patients 40 (80%) were males. All patients were treated with antiretroviral therapy. The ALT levels were normal in 13 (26%) patients. HCV-HIV co-infected patients with normal ALT levels had presented means of the liver fibrosis stages (0.77±0.44 versus 1.86±1.38; p<0.001) periportal inflammatory activity (0.62±0.77 versus 2.24±1.35; p<0.001) and liver fibrosis progression rate (0.058±0.043 fibrosis unit/year versus 0.118±0.102 fibrosis unit/year) significantly lower as compared to those with elevated ALT. CONCLUSIONS: HCV-HIV coinfected patients with persistently normal ALTs showed slower progression of liver fibrosis. In these patients the development of liver cirrhosis is improbable. |
format |
Article in Journal/Newspaper |
author |
Fábio Heleno de Lima Pace Lincoln Eduardo Vieira de Castro Ferreira Antonio Eduardo Benedito Silva Maria Lucia Gomes Ferraz |
author_facet |
Fábio Heleno de Lima Pace Lincoln Eduardo Vieira de Castro Ferreira Antonio Eduardo Benedito Silva Maria Lucia Gomes Ferraz |
author_sort |
Fábio Heleno de Lima Pace |
title |
Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels |
title_short |
Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels |
title_full |
Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels |
title_fullStr |
Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels |
title_full_unstemmed |
Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels |
title_sort |
liver fibrosis progression in hiv/hepatitis c virus coinfected patients with normal aminotransferases levels |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2012 |
url |
https://doi.org/10.1590/S0037-86822012000400005 https://doaj.org/article/09549bcd331f4dada8d9bcceaa7fb701 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 4, Pp 444-447 (2012) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000400005&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822012000400005 https://doaj.org/article/09549bcd331f4dada8d9bcceaa7fb701 |
op_doi |
https://doi.org/10.1590/S0037-86822012000400005 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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45 |
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444 |
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447 |
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