Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice
Objective: To evaluate the potential of Gracilaria changii extract in ameliorating the potential adverse effects of bisphenol A. Methods: The antioxidant capacity of Gracilaria changii extracted using different solvents (methanol, ethanol, and aqueous) was studied. The mice were administered by oral...
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ftdoajarticles:oai:doaj.org/article:08cbcb2bb489410f991b37604297effe 2023-05-15T15:10:00+02:00 Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice Chong Lee Ng Gim Cheong Tan Yoon-Yen Yow Mukesh Kumar Gupta Phek Jin Kwong 2021-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.304299 https://doaj.org/article/08cbcb2bb489410f991b37604297effe EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=1;spage=34;epage=43;aulast=Ng https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.304299 https://doaj.org/article/08cbcb2bb489410f991b37604297effe Asian Pacific Journal of Tropical Medicine, Vol 14, Iss 1, Pp 34-43 (2021) red seaweed gracilaria changii antioxidant endocrine disruptor bisphenol a reproduction Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.4103/1995-7645.304299 2022-12-30T20:39:25Z Objective: To evaluate the potential of Gracilaria changii extract in ameliorating the potential adverse effects of bisphenol A. Methods: The antioxidant capacity of Gracilaria changii extracted using different solvents (methanol, ethanol, and aqueous) was studied. The mice were administered by oral gavage with bisphenol A (60 mg/kg body weight) for 6 weeks with or without Gracilaria changii aqueous extract. Thereafter, the mice were either euthanized for histology and immunohistochemistry studies or mated to evaluate the pregnancy rate. Results: Gracilaria changii aqueous extract showed the highest antioxidant properties compared with extract using methanol and ethanol. The aqueous extract of Gracilaria changii improved the uterus index and uterine lipid peroxidation after bisphenol A exposure, although the uterine expressions of estrogen receptors and complement C3 were not improved. Histological evaluation of the uterus during the estrus stage has revealed that the extract could mitigate bisphenol A-induced adverse effects in the uterus as there was a lower percentage of mice showing abnormalities like decreased eosin staining in the myometrium, and decrease in the number of eosinophil and endometrial glands in the endometrium. Besides, Gracilaria changii aqueous extract improved the pregnancy rate of mice administered with bisphenol A. Conclusions: Gracilaria changii extract protects against bisphenol A-induced female reproductive abnormalities in mice which may be mediated via modulation of eosinophil migration, endometrial gland formation, and protein expressions associated with prostaglandins in the myometrium. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 14 1 34 |
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red seaweed gracilaria changii antioxidant endocrine disruptor bisphenol a reproduction Arctic medicine. Tropical medicine RC955-962 |
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red seaweed gracilaria changii antioxidant endocrine disruptor bisphenol a reproduction Arctic medicine. Tropical medicine RC955-962 Chong Lee Ng Gim Cheong Tan Yoon-Yen Yow Mukesh Kumar Gupta Phek Jin Kwong Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
topic_facet |
red seaweed gracilaria changii antioxidant endocrine disruptor bisphenol a reproduction Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To evaluate the potential of Gracilaria changii extract in ameliorating the potential adverse effects of bisphenol A. Methods: The antioxidant capacity of Gracilaria changii extracted using different solvents (methanol, ethanol, and aqueous) was studied. The mice were administered by oral gavage with bisphenol A (60 mg/kg body weight) for 6 weeks with or without Gracilaria changii aqueous extract. Thereafter, the mice were either euthanized for histology and immunohistochemistry studies or mated to evaluate the pregnancy rate. Results: Gracilaria changii aqueous extract showed the highest antioxidant properties compared with extract using methanol and ethanol. The aqueous extract of Gracilaria changii improved the uterus index and uterine lipid peroxidation after bisphenol A exposure, although the uterine expressions of estrogen receptors and complement C3 were not improved. Histological evaluation of the uterus during the estrus stage has revealed that the extract could mitigate bisphenol A-induced adverse effects in the uterus as there was a lower percentage of mice showing abnormalities like decreased eosin staining in the myometrium, and decrease in the number of eosinophil and endometrial glands in the endometrium. Besides, Gracilaria changii aqueous extract improved the pregnancy rate of mice administered with bisphenol A. Conclusions: Gracilaria changii extract protects against bisphenol A-induced female reproductive abnormalities in mice which may be mediated via modulation of eosinophil migration, endometrial gland formation, and protein expressions associated with prostaglandins in the myometrium. |
format |
Article in Journal/Newspaper |
author |
Chong Lee Ng Gim Cheong Tan Yoon-Yen Yow Mukesh Kumar Gupta Phek Jin Kwong |
author_facet |
Chong Lee Ng Gim Cheong Tan Yoon-Yen Yow Mukesh Kumar Gupta Phek Jin Kwong |
author_sort |
Chong Lee Ng |
title |
Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
title_short |
Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
title_full |
Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
title_fullStr |
Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
title_full_unstemmed |
Gracilaria changii (Rhodophyta) alleviates bisphenol A-induced adverse reproductive abnormalities in mice |
title_sort |
gracilaria changii (rhodophyta) alleviates bisphenol a-induced adverse reproductive abnormalities in mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2021 |
url |
https://doi.org/10.4103/1995-7645.304299 https://doaj.org/article/08cbcb2bb489410f991b37604297effe |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 14, Iss 1, Pp 34-43 (2021) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=1;spage=34;epage=43;aulast=Ng https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.304299 https://doaj.org/article/08cbcb2bb489410f991b37604297effe |
op_doi |
https://doi.org/10.4103/1995-7645.304299 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
14 |
container_issue |
1 |
container_start_page |
34 |
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1766341081567330304 |