Dicer-2-dependent activation of Culex Vago occurs via the TRAF-Rel2 signaling pathway.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Prasad N Paradkar, Jean-Bernard Duchemin, Rhonda Voysey, Peter J Walker
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2014
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Vago
• Online Access: https://doi.org/10.1371/journal.pntd.0002823; https://doaj.org/article/08b9af2b9c954542937c7c7728f74d90

Despite their importance as vectors of human and livestock diseases, relatively little is known about innate antiviral immune pathways in mosquitoes and other insects. Previous work has shown that Culex Vago (CxVago), which is induced and secreted from West Nile virus (WNV)-infected mosquito cells,...