Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea.
Plasmodium vivax is highly endemic in the lowlands of Papua New Guinea and accounts for a large proportion of the malaria cases in children less than 5 years of age. We collected 2117 blood samples at 2-monthly intervals from a cohort of 268 children aged 1 to 4.5 years and estimated the diversity a...
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ftdoajarticles:oai:doaj.org/article:08b3f08b5c9e4ceaa070561b3e974ae1 2023-05-15T15:05:15+02:00 Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea. Cristian Koepfli Amanda Ross Benson Kiniboro Thomas A Smith Peter A Zimmerman Peter Siba Ivo Mueller Ingrid Felger 2011-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001424 https://doaj.org/article/08b3f08b5c9e4ceaa070561b3e974ae1 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3243695?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001424 https://doaj.org/article/08b3f08b5c9e4ceaa070561b3e974ae1 PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1424 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001424 2023-01-08T01:28:23Z Plasmodium vivax is highly endemic in the lowlands of Papua New Guinea and accounts for a large proportion of the malaria cases in children less than 5 years of age. We collected 2117 blood samples at 2-monthly intervals from a cohort of 268 children aged 1 to 4.5 years and estimated the diversity and multiplicity of P. vivax infection. All P. vivax clones were genotyped using the merozoite surface protein 1 F3 fragment (msp1F3) and the microsatellite MS16 as molecular markers. High diversity was observed with msp1F3 (H(E) = 88.1%) and MS16 (H(E) = 97.8%). Of the 1162 P. vivax positive samples, 74% harbored multi-clone infections with a mean multiplicity of 2.7 (IQR = 1-3). The multiplicity of P. vivax infection increased slightly with age (P = 0.02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and monitoring the effects of interventions. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 12 e1424 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Cristian Koepfli Amanda Ross Benson Kiniboro Thomas A Smith Peter A Zimmerman Peter Siba Ivo Mueller Ingrid Felger Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Plasmodium vivax is highly endemic in the lowlands of Papua New Guinea and accounts for a large proportion of the malaria cases in children less than 5 years of age. We collected 2117 blood samples at 2-monthly intervals from a cohort of 268 children aged 1 to 4.5 years and estimated the diversity and multiplicity of P. vivax infection. All P. vivax clones were genotyped using the merozoite surface protein 1 F3 fragment (msp1F3) and the microsatellite MS16 as molecular markers. High diversity was observed with msp1F3 (H(E) = 88.1%) and MS16 (H(E) = 97.8%). Of the 1162 P. vivax positive samples, 74% harbored multi-clone infections with a mean multiplicity of 2.7 (IQR = 1-3). The multiplicity of P. vivax infection increased slightly with age (P = 0.02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and monitoring the effects of interventions. |
format |
Article in Journal/Newspaper |
author |
Cristian Koepfli Amanda Ross Benson Kiniboro Thomas A Smith Peter A Zimmerman Peter Siba Ivo Mueller Ingrid Felger |
author_facet |
Cristian Koepfli Amanda Ross Benson Kiniboro Thomas A Smith Peter A Zimmerman Peter Siba Ivo Mueller Ingrid Felger |
author_sort |
Cristian Koepfli |
title |
Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea. |
title_short |
Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea. |
title_full |
Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea. |
title_fullStr |
Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea. |
title_full_unstemmed |
Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea. |
title_sort |
multiplicity and diversity of plasmodium vivax infections in a highly endemic region in papua new guinea. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001424 https://doaj.org/article/08b3f08b5c9e4ceaa070561b3e974ae1 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1424 (2011) |
op_relation |
http://europepmc.org/articles/PMC3243695?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001424 https://doaj.org/article/08b3f08b5c9e4ceaa070561b3e974ae1 |
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https://doi.org/10.1371/journal.pntd.0001424 |
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PLoS Neglected Tropical Diseases |
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5 |
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12 |
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e1424 |
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