Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome
Abstract Background Salmonids are one of the most intensely studied fish, in part due to their economic and environmental importance, and in part due to a recent whole genome duplication in the common ancestor of salmonids. This duplication greatly impacts species diversification, functional special...
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ftdoajarticles:oai:doaj.org/article:08779e0193c443b9aaa329a1e88b9a87 2023-05-15T15:31:41+02:00 Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome Holt Robert A Moore Richard Munro Sarah Liao Nancy Y Messmer Amber M Cooper Glenn A von Schalburg Kristian R Jantzen Stuart G Leong Jong S Jones Steven JM Davidson William S Koop Ben F 2010-04-01T00:00:00Z https://doi.org/10.1186/1471-2164-11-279 https://doaj.org/article/08779e0193c443b9aaa329a1e88b9a87 EN eng BMC http://www.biomedcentral.com/1471-2164/11/279 https://doaj.org/toc/1471-2164 doi:10.1186/1471-2164-11-279 1471-2164 https://doaj.org/article/08779e0193c443b9aaa329a1e88b9a87 BMC Genomics, Vol 11, Iss 1, p 279 (2010) Biotechnology TP248.13-248.65 Genetics QH426-470 article 2010 ftdoajarticles https://doi.org/10.1186/1471-2164-11-279 2022-12-31T08:35:07Z Abstract Background Salmonids are one of the most intensely studied fish, in part due to their economic and environmental importance, and in part due to a recent whole genome duplication in the common ancestor of salmonids. This duplication greatly impacts species diversification, functional specialization, and adaptation. Extensive new genomic resources have recently become available for Atlantic salmon ( Salmo salar ), but documentation of allelic versus duplicate reference genes remains a major uncertainty in the complete characterization of its genome and its evolution. Results From existing expressed sequence tag (EST) resources and three new full-length cDNA libraries, 9,057 reference quality full-length gene insert clones were identified for Atlantic salmon. A further 1,365 reference full-length clones were annotated from 29,221 northern pike ( Esox lucius ) ESTs. Pairwise d N /d S comparisons within each of 408 sets of duplicated salmon genes using northern pike as a diploid out-group show asymmetric relaxation of selection on salmon duplicates. Conclusions 9,057 full-length reference genes were characterized in S. salar and can be used to identify alleles and gene family members. Comparisons of duplicated genes show that while purifying selection is the predominant force acting on both duplicates, consistent with retention of functionality in both copies, some relaxation of pressure on gene duplicates can be identified. In addition, there is evidence that evolution has acted asymmetrically on paralogs, allowing one of the pair to diverge at a faster rate. Article in Journal/Newspaper Atlantic salmon Salmo salar Directory of Open Access Journals: DOAJ Articles BMC Genomics 11 1 279 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Biotechnology TP248.13-248.65 Genetics QH426-470 |
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Biotechnology TP248.13-248.65 Genetics QH426-470 Holt Robert A Moore Richard Munro Sarah Liao Nancy Y Messmer Amber M Cooper Glenn A von Schalburg Kristian R Jantzen Stuart G Leong Jong S Jones Steven JM Davidson William S Koop Ben F Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome |
topic_facet |
Biotechnology TP248.13-248.65 Genetics QH426-470 |
description |
Abstract Background Salmonids are one of the most intensely studied fish, in part due to their economic and environmental importance, and in part due to a recent whole genome duplication in the common ancestor of salmonids. This duplication greatly impacts species diversification, functional specialization, and adaptation. Extensive new genomic resources have recently become available for Atlantic salmon ( Salmo salar ), but documentation of allelic versus duplicate reference genes remains a major uncertainty in the complete characterization of its genome and its evolution. Results From existing expressed sequence tag (EST) resources and three new full-length cDNA libraries, 9,057 reference quality full-length gene insert clones were identified for Atlantic salmon. A further 1,365 reference full-length clones were annotated from 29,221 northern pike ( Esox lucius ) ESTs. Pairwise d N /d S comparisons within each of 408 sets of duplicated salmon genes using northern pike as a diploid out-group show asymmetric relaxation of selection on salmon duplicates. Conclusions 9,057 full-length reference genes were characterized in S. salar and can be used to identify alleles and gene family members. Comparisons of duplicated genes show that while purifying selection is the predominant force acting on both duplicates, consistent with retention of functionality in both copies, some relaxation of pressure on gene duplicates can be identified. In addition, there is evidence that evolution has acted asymmetrically on paralogs, allowing one of the pair to diverge at a faster rate. |
format |
Article in Journal/Newspaper |
author |
Holt Robert A Moore Richard Munro Sarah Liao Nancy Y Messmer Amber M Cooper Glenn A von Schalburg Kristian R Jantzen Stuart G Leong Jong S Jones Steven JM Davidson William S Koop Ben F |
author_facet |
Holt Robert A Moore Richard Munro Sarah Liao Nancy Y Messmer Amber M Cooper Glenn A von Schalburg Kristian R Jantzen Stuart G Leong Jong S Jones Steven JM Davidson William S Koop Ben F |
author_sort |
Holt Robert A |
title |
Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome |
title_short |
Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome |
title_full |
Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome |
title_fullStr |
Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome |
title_full_unstemmed |
Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome |
title_sort |
salmo salar and esox lucius full-length cdna sequences reveal changes in evolutionary pressures on a post-tetraploidization genome |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1471-2164-11-279 https://doaj.org/article/08779e0193c443b9aaa329a1e88b9a87 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
BMC Genomics, Vol 11, Iss 1, p 279 (2010) |
op_relation |
http://www.biomedcentral.com/1471-2164/11/279 https://doaj.org/toc/1471-2164 doi:10.1186/1471-2164-11-279 1471-2164 https://doaj.org/article/08779e0193c443b9aaa329a1e88b9a87 |
op_doi |
https://doi.org/10.1186/1471-2164-11-279 |
container_title |
BMC Genomics |
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11 |
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1 |
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279 |
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1766362216097906688 |