Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population
ABSTRACT This study presents 25 cases of recurrent respiratory papillomatosis (RRP) that occurred in Sao Luis, Maranhao State, Northeast region, Brazil, between January 2007 and December 2018. Sociodemographic and clinical profile of patients as well as human papillomavirus (HPV) infection status we...
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Universidade de São Paulo (USP)
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ftdoajarticles:oai:doaj.org/article:0852650dd2a84adbb3fb5db7e50871a5 2024-09-09T19:27:31+00:00 Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population Ana Maria Almeida Silva Carvalho Danielle Salgado de Brito Ana Paula Almeida Cunha Pablo de Matos Monteiro Mariele Borges Ferreira Diogo Souza Ferreira Rubim de Assis Janaína Oliveira Bentivi Marcelo Souza de Andrade Flávia Castello Branco Vidal Natalino Salgado Filho 2021-08-01T00:00:00Z https://doi.org/10.1590/s1678-9946202163063 https://doaj.org/article/0852650dd2a84adbb3fb5db7e50871a5 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652021000100234&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946202163063 https://doaj.org/article/0852650dd2a84adbb3fb5db7e50871a5 Revista do Instituto de Medicina Tropical de São Paulo, Vol 63 (2021) Recurrent respiratory papillomatosis Human papillomavirus Genotype Larynx Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1590/s1678-9946202163063 2024-08-05T17:49:30Z ABSTRACT This study presents 25 cases of recurrent respiratory papillomatosis (RRP) that occurred in Sao Luis, Maranhao State, Northeast region, Brazil, between January 2007 and December 2018. Sociodemographic and clinical profile of patients as well as human papillomavirus (HPV) infection status were evaluated. Clinical and histopathological data were collected from the patients’ medical records. For the HPV infection analysis, DNA was extracted and subjected to amplification by a nested polymerase chain reaction. Viral genotyping was performed by automated sequencing. The median age of patients was 12.40 ± 12.6. years, and the juvenile form of the disease (68%) was the predominant form of disease. Female participants were predominant (60%), and they were from cities located in the interior of the State (60%). The most common clinical manifestation was dysphonia; recurrence was observed in most cases (56%), and tracheostomy was necessary in seven patients (26.9%). When comparing the RRP forms, patients in the juvenile-RRP group had higher recurrence rates and need of tracheostomy than those in the adult-RRP group. The viral genotyping analysis revealed that 47.8% of patients had low-risk HPVs, whereas 13.1% had high-risk HPVs, and in 39.1% of patients the viral genotype was not obtained. HPV-6 was the most prevalent type and Juvenile-RRP was more prevalent in our population. HPV was present at a high rate, and HPV-6 was the predominant genotype. This study serves as the basis for further studies to be conducted in the Brazilian population. Our findings aid the better understanding of RRP, possibly suggesting some prognostic factors associated with the disease aggressiveness. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 63 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
Recurrent respiratory papillomatosis Human papillomavirus Genotype Larynx Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Recurrent respiratory papillomatosis Human papillomavirus Genotype Larynx Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ana Maria Almeida Silva Carvalho Danielle Salgado de Brito Ana Paula Almeida Cunha Pablo de Matos Monteiro Mariele Borges Ferreira Diogo Souza Ferreira Rubim de Assis Janaína Oliveira Bentivi Marcelo Souza de Andrade Flávia Castello Branco Vidal Natalino Salgado Filho Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population |
topic_facet |
Recurrent respiratory papillomatosis Human papillomavirus Genotype Larynx Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT This study presents 25 cases of recurrent respiratory papillomatosis (RRP) that occurred in Sao Luis, Maranhao State, Northeast region, Brazil, between January 2007 and December 2018. Sociodemographic and clinical profile of patients as well as human papillomavirus (HPV) infection status were evaluated. Clinical and histopathological data were collected from the patients’ medical records. For the HPV infection analysis, DNA was extracted and subjected to amplification by a nested polymerase chain reaction. Viral genotyping was performed by automated sequencing. The median age of patients was 12.40 ± 12.6. years, and the juvenile form of the disease (68%) was the predominant form of disease. Female participants were predominant (60%), and they were from cities located in the interior of the State (60%). The most common clinical manifestation was dysphonia; recurrence was observed in most cases (56%), and tracheostomy was necessary in seven patients (26.9%). When comparing the RRP forms, patients in the juvenile-RRP group had higher recurrence rates and need of tracheostomy than those in the adult-RRP group. The viral genotyping analysis revealed that 47.8% of patients had low-risk HPVs, whereas 13.1% had high-risk HPVs, and in 39.1% of patients the viral genotype was not obtained. HPV-6 was the most prevalent type and Juvenile-RRP was more prevalent in our population. HPV was present at a high rate, and HPV-6 was the predominant genotype. This study serves as the basis for further studies to be conducted in the Brazilian population. Our findings aid the better understanding of RRP, possibly suggesting some prognostic factors associated with the disease aggressiveness. |
format |
Article in Journal/Newspaper |
author |
Ana Maria Almeida Silva Carvalho Danielle Salgado de Brito Ana Paula Almeida Cunha Pablo de Matos Monteiro Mariele Borges Ferreira Diogo Souza Ferreira Rubim de Assis Janaína Oliveira Bentivi Marcelo Souza de Andrade Flávia Castello Branco Vidal Natalino Salgado Filho |
author_facet |
Ana Maria Almeida Silva Carvalho Danielle Salgado de Brito Ana Paula Almeida Cunha Pablo de Matos Monteiro Mariele Borges Ferreira Diogo Souza Ferreira Rubim de Assis Janaína Oliveira Bentivi Marcelo Souza de Andrade Flávia Castello Branco Vidal Natalino Salgado Filho |
author_sort |
Ana Maria Almeida Silva Carvalho |
title |
Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population |
title_short |
Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population |
title_full |
Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population |
title_fullStr |
Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population |
title_full_unstemmed |
Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population |
title_sort |
recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a brazilian population |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2021 |
url |
https://doi.org/10.1590/s1678-9946202163063 https://doaj.org/article/0852650dd2a84adbb3fb5db7e50871a5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 63 (2021) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652021000100234&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946202163063 https://doaj.org/article/0852650dd2a84adbb3fb5db7e50871a5 |
op_doi |
https://doi.org/10.1590/s1678-9946202163063 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
63 |
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