Integrated Analysis of Environment, Cattle and Human Serological Data: Risks and Mechanisms of Transmission of Rift Valley Fever in Madagascar.
BACKGROUND:Rift Valley fever (RVF) is a vector-borne disease affecting ruminants and humans. Madagascar was heavily affected by RVF in 2008-2009, with evidence of a large and heterogeneous spread of the disease. The identification of at-risk environments is essential to optimize the available resour...
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ftdoajarticles:oai:doaj.org/article:08070a5d3b3d4075aa20ad6a9d83fd2a 2023-05-15T15:14:21+02:00 Integrated Analysis of Environment, Cattle and Human Serological Data: Risks and Mechanisms of Transmission of Rift Valley Fever in Madagascar. Marie-Marie Olive Véronique Chevalier Vladimir Grosbois Annelise Tran Soa-Fy Andriamandimby Benoit Durand Jean-Pierre Ravalohery Seta Andriamamonjy Fanjasoa Rakotomanana Christophe Rogier Jean-Michel Heraud 2016-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004827 https://doaj.org/article/08070a5d3b3d4075aa20ad6a9d83fd2a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4945045?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004827 https://doaj.org/article/08070a5d3b3d4075aa20ad6a9d83fd2a PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004827 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004827 2022-12-31T14:27:56Z BACKGROUND:Rift Valley fever (RVF) is a vector-borne disease affecting ruminants and humans. Madagascar was heavily affected by RVF in 2008-2009, with evidence of a large and heterogeneous spread of the disease. The identification of at-risk environments is essential to optimize the available resources by targeting RVF surveillance in Madagascar. Herein, the objectives of our study were: (i) to identify the environmental factors and areas favorable to RVF transmission to both cattle and human and (ii) to identify human behaviors favoring human infections in Malagasy contexts. METHODOLOGY/PRINCIPAL FINDINGS:First, we characterized the environments of Malagasy communes using a Multiple Factor Analysis (MFA). Then, we analyzed cattle and human serological data collected at national level using Generalized Linear Mixed Models, with the individual serological status (cattle or human) as the response, and MFA factors, as well as other potential risk factors (cattle density, human behavior) as explanatory variables. Cattle and human seroprevalence rates were positively associated to humid environments (p<0.001). Areas with high cattle density were at risk (p<0.01; OR = 2.6). Furthermore, our analysis showed that frequent contact with raw milk contributed to explain human infection (OR = 1.6). Finally, our study highlighted the eastern-coast, western and north-western parts as high-risk areas for RVF transmission in cattle. CONCLUSIONS/SIGNIFICANCE:Our integrated approach analyzing environmental, cattle and human datasets allow us to bring new insight on RVF transmission patterns in Madagascar. The association between cattle seroprevalence, humid environments and high cattle density suggests that concomitant vectorial and direct transmissions are critical to maintain RVF enzootic transmission. Additionally, in the at-risk humid environment of the western, north-western and the eastern-coast areas, suitable to Culex and Anopheles mosquitoes, vectorial transmission probably occurs in both cattle and human. The ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 7 e0004827 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Marie-Marie Olive Véronique Chevalier Vladimir Grosbois Annelise Tran Soa-Fy Andriamandimby Benoit Durand Jean-Pierre Ravalohery Seta Andriamamonjy Fanjasoa Rakotomanana Christophe Rogier Jean-Michel Heraud Integrated Analysis of Environment, Cattle and Human Serological Data: Risks and Mechanisms of Transmission of Rift Valley Fever in Madagascar. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Rift Valley fever (RVF) is a vector-borne disease affecting ruminants and humans. Madagascar was heavily affected by RVF in 2008-2009, with evidence of a large and heterogeneous spread of the disease. The identification of at-risk environments is essential to optimize the available resources by targeting RVF surveillance in Madagascar. Herein, the objectives of our study were: (i) to identify the environmental factors and areas favorable to RVF transmission to both cattle and human and (ii) to identify human behaviors favoring human infections in Malagasy contexts. METHODOLOGY/PRINCIPAL FINDINGS:First, we characterized the environments of Malagasy communes using a Multiple Factor Analysis (MFA). Then, we analyzed cattle and human serological data collected at national level using Generalized Linear Mixed Models, with the individual serological status (cattle or human) as the response, and MFA factors, as well as other potential risk factors (cattle density, human behavior) as explanatory variables. Cattle and human seroprevalence rates were positively associated to humid environments (p<0.001). Areas with high cattle density were at risk (p<0.01; OR = 2.6). Furthermore, our analysis showed that frequent contact with raw milk contributed to explain human infection (OR = 1.6). Finally, our study highlighted the eastern-coast, western and north-western parts as high-risk areas for RVF transmission in cattle. CONCLUSIONS/SIGNIFICANCE:Our integrated approach analyzing environmental, cattle and human datasets allow us to bring new insight on RVF transmission patterns in Madagascar. The association between cattle seroprevalence, humid environments and high cattle density suggests that concomitant vectorial and direct transmissions are critical to maintain RVF enzootic transmission. Additionally, in the at-risk humid environment of the western, north-western and the eastern-coast areas, suitable to Culex and Anopheles mosquitoes, vectorial transmission probably occurs in both cattle and human. The ... |
format |
Article in Journal/Newspaper |
author |
Marie-Marie Olive Véronique Chevalier Vladimir Grosbois Annelise Tran Soa-Fy Andriamandimby Benoit Durand Jean-Pierre Ravalohery Seta Andriamamonjy Fanjasoa Rakotomanana Christophe Rogier Jean-Michel Heraud |
author_facet |
Marie-Marie Olive Véronique Chevalier Vladimir Grosbois Annelise Tran Soa-Fy Andriamandimby Benoit Durand Jean-Pierre Ravalohery Seta Andriamamonjy Fanjasoa Rakotomanana Christophe Rogier Jean-Michel Heraud |
author_sort |
Marie-Marie Olive |
title |
Integrated Analysis of Environment, Cattle and Human Serological Data: Risks and Mechanisms of Transmission of Rift Valley Fever in Madagascar. |
title_short |
Integrated Analysis of Environment, Cattle and Human Serological Data: Risks and Mechanisms of Transmission of Rift Valley Fever in Madagascar. |
title_full |
Integrated Analysis of Environment, Cattle and Human Serological Data: Risks and Mechanisms of Transmission of Rift Valley Fever in Madagascar. |
title_fullStr |
Integrated Analysis of Environment, Cattle and Human Serological Data: Risks and Mechanisms of Transmission of Rift Valley Fever in Madagascar. |
title_full_unstemmed |
Integrated Analysis of Environment, Cattle and Human Serological Data: Risks and Mechanisms of Transmission of Rift Valley Fever in Madagascar. |
title_sort |
integrated analysis of environment, cattle and human serological data: risks and mechanisms of transmission of rift valley fever in madagascar. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004827 https://doaj.org/article/08070a5d3b3d4075aa20ad6a9d83fd2a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004827 (2016) |
op_relation |
http://europepmc.org/articles/PMC4945045?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004827 https://doaj.org/article/08070a5d3b3d4075aa20ad6a9d83fd2a |
op_doi |
https://doi.org/10.1371/journal.pntd.0004827 |
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PLOS Neglected Tropical Diseases |
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10 |
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7 |
container_start_page |
e0004827 |
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