The association between obesity and dengue severity among pediatric patients: A systematic review and meta-analysis.
Severe dengue infection often has unpredictable clinical progressions and outcomes. Obesity may play a role in the deterioration of dengue infection due to stronger body immune responses. Several studies found that obese dengue patients have a more severe presentation with a poorer prognosis. Howeve...
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ftdoajarticles:oai:doaj.org/article:07f3826bfb154d34924c3ebbd90590ff 2023-05-15T15:12:25+02:00 The association between obesity and dengue severity among pediatric patients: A systematic review and meta-analysis. Mohd Syis Zulkipli Maznah Dahlui Nor'ashikin Jamil Devi Peramalah Hoe Victor Chee Wai Awang Bulgiba Sanjay Rampal 2018-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006263 https://doaj.org/article/07f3826bfb154d34924c3ebbd90590ff EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5819989?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006263 https://doaj.org/article/07f3826bfb154d34924c3ebbd90590ff PLoS Neglected Tropical Diseases, Vol 12, Iss 2, p e0006263 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006263 2022-12-31T00:17:50Z Severe dengue infection often has unpredictable clinical progressions and outcomes. Obesity may play a role in the deterioration of dengue infection due to stronger body immune responses. Several studies found that obese dengue patients have a more severe presentation with a poorer prognosis. However, the association was inconclusive due to the variation in the results of earlier studies. Therefore, we conducted a systematic review and meta-analysis to explore the relationship between obesity and dengue severity.We performed a systematic search of relevant studies on Ovid (MEDLINE), EMBASE, the Cochrane Library, Web of Science, Scopus and grey literature databases. At least two authors independently conducted the literature search, selecting eligible studies, and extracting data. Meta-analysis using random-effects model was conducted to compute the pooled odds ratio with 95% confidence intervals (CI).We obtained a total of 13,333 articles from the searches. For the final analysis, we included a total of fifteen studies among pediatric patients. Three cohort studies, two case-control studies, and one cross-sectional study found an association between obesity and dengue severity. In contrast, six cohort studies and three case-control studies found no significant relationship between obesity and dengue severity. Our meta-analysis revealed that there was 38 percent higher odds (Odds Ratio = 1.38; 95% CI:1.10, 1.73) of developing severe dengue infection among obese children compared to non-obese children. We found no heterogeneity found between studies. The differences in obesity classification, study quality, and study design do not modify the association between obesity and dengue severity.This review found that obesity is a risk factor for dengue severity among children. The result highlights and improves our understanding that obesity might influence the severity of dengue infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 2 e0006263 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Mohd Syis Zulkipli Maznah Dahlui Nor'ashikin Jamil Devi Peramalah Hoe Victor Chee Wai Awang Bulgiba Sanjay Rampal The association between obesity and dengue severity among pediatric patients: A systematic review and meta-analysis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Severe dengue infection often has unpredictable clinical progressions and outcomes. Obesity may play a role in the deterioration of dengue infection due to stronger body immune responses. Several studies found that obese dengue patients have a more severe presentation with a poorer prognosis. However, the association was inconclusive due to the variation in the results of earlier studies. Therefore, we conducted a systematic review and meta-analysis to explore the relationship between obesity and dengue severity.We performed a systematic search of relevant studies on Ovid (MEDLINE), EMBASE, the Cochrane Library, Web of Science, Scopus and grey literature databases. At least two authors independently conducted the literature search, selecting eligible studies, and extracting data. Meta-analysis using random-effects model was conducted to compute the pooled odds ratio with 95% confidence intervals (CI).We obtained a total of 13,333 articles from the searches. For the final analysis, we included a total of fifteen studies among pediatric patients. Three cohort studies, two case-control studies, and one cross-sectional study found an association between obesity and dengue severity. In contrast, six cohort studies and three case-control studies found no significant relationship between obesity and dengue severity. Our meta-analysis revealed that there was 38 percent higher odds (Odds Ratio = 1.38; 95% CI:1.10, 1.73) of developing severe dengue infection among obese children compared to non-obese children. We found no heterogeneity found between studies. The differences in obesity classification, study quality, and study design do not modify the association between obesity and dengue severity.This review found that obesity is a risk factor for dengue severity among children. The result highlights and improves our understanding that obesity might influence the severity of dengue infection. |
format |
Article in Journal/Newspaper |
author |
Mohd Syis Zulkipli Maznah Dahlui Nor'ashikin Jamil Devi Peramalah Hoe Victor Chee Wai Awang Bulgiba Sanjay Rampal |
author_facet |
Mohd Syis Zulkipli Maznah Dahlui Nor'ashikin Jamil Devi Peramalah Hoe Victor Chee Wai Awang Bulgiba Sanjay Rampal |
author_sort |
Mohd Syis Zulkipli |
title |
The association between obesity and dengue severity among pediatric patients: A systematic review and meta-analysis. |
title_short |
The association between obesity and dengue severity among pediatric patients: A systematic review and meta-analysis. |
title_full |
The association between obesity and dengue severity among pediatric patients: A systematic review and meta-analysis. |
title_fullStr |
The association between obesity and dengue severity among pediatric patients: A systematic review and meta-analysis. |
title_full_unstemmed |
The association between obesity and dengue severity among pediatric patients: A systematic review and meta-analysis. |
title_sort |
association between obesity and dengue severity among pediatric patients: a systematic review and meta-analysis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006263 https://doaj.org/article/07f3826bfb154d34924c3ebbd90590ff |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 2, p e0006263 (2018) |
op_relation |
http://europepmc.org/articles/PMC5819989?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006263 https://doaj.org/article/07f3826bfb154d34924c3ebbd90590ff |
op_doi |
https://doi.org/10.1371/journal.pntd.0006263 |
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PLOS Neglected Tropical Diseases |
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12 |
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2 |
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e0006263 |
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1766343093896871936 |