Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract: In vitro and in vivo study
Objective: To evaluate the in vitro and in vivo effect of the Algerian propolis ethanolic extract (EEP) against Echinococcus granulosus (E. granulosus) infection. Methods: In vitro scolicidal activity of EEP was investigated on the protoscolices of hydatid cyst. This in vitro study was conducted by...
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ftdoajarticles:oai:doaj.org/article:07460338d8bb4301bb0b175d4b8b5e87 2023-05-15T15:07:32+02:00 Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract: In vitro and in vivo study Nahla Deghbar Dalila Mezioug Touri Kahina Yacine-Miloud Medjdoub Chafia Touil- Boukoffa 2019-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.254936 https://doaj.org/article/07460338d8bb4301bb0b175d4b8b5e87 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=3;spage=106;epage=116;aulast=Deghbar https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.254936 https://doaj.org/article/07460338d8bb4301bb0b175d4b8b5e87 Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 3, Pp 106-116 (2019) cystic echinococcosis algerian propolis antihydatic effect immunomodulatory effect Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.4103/1995-7645.254936 2022-12-31T01:16:39Z Objective: To evaluate the in vitro and in vivo effect of the Algerian propolis ethanolic extract (EEP) against Echinococcus granulosus (E. granulosus) infection. Methods: In vitro scolicidal activity of EEP was investigated on the protoscolices of hydatid cyst. This in vitro study was conducted by using an in vivo assay. BALB/c mice were inoculated with E. granulosus and treated with propolis for three months. Hydatid cysts development was assessed. Nitric oxide (NO), tumor necrosis factor alpha (TNF-α) production and inducible NO synthase, NF-κB, and TNF-α spleen expression were estimated by Griess method and immunofluorescence respectively. Results: Our study revealed that EEP has a high scolicidal activity against E. granulosus. Oral administration of EEP decreased TNF-α, NF-κB and inducible NO synthase expression in the spleen tissues in the CE+EEP group, in comparison with the CE group. Concomitantly, EEP treatment caused an important systemic decrease in NO and TNF-α levels. These findings are associated with the reduction of CE development. Conclusions: This is the first report demonstrating with interest the antihydatic and immunomodulatory effects of the Algerian EEP, suggesting its therapeutic potential for the hydatid disease treatment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 12 3 106 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
cystic echinococcosis algerian propolis antihydatic effect immunomodulatory effect Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
cystic echinococcosis algerian propolis antihydatic effect immunomodulatory effect Arctic medicine. Tropical medicine RC955-962 Nahla Deghbar Dalila Mezioug Touri Kahina Yacine-Miloud Medjdoub Chafia Touil- Boukoffa Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract: In vitro and in vivo study |
topic_facet |
cystic echinococcosis algerian propolis antihydatic effect immunomodulatory effect Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To evaluate the in vitro and in vivo effect of the Algerian propolis ethanolic extract (EEP) against Echinococcus granulosus (E. granulosus) infection. Methods: In vitro scolicidal activity of EEP was investigated on the protoscolices of hydatid cyst. This in vitro study was conducted by using an in vivo assay. BALB/c mice were inoculated with E. granulosus and treated with propolis for three months. Hydatid cysts development was assessed. Nitric oxide (NO), tumor necrosis factor alpha (TNF-α) production and inducible NO synthase, NF-κB, and TNF-α spleen expression were estimated by Griess method and immunofluorescence respectively. Results: Our study revealed that EEP has a high scolicidal activity against E. granulosus. Oral administration of EEP decreased TNF-α, NF-κB and inducible NO synthase expression in the spleen tissues in the CE+EEP group, in comparison with the CE group. Concomitantly, EEP treatment caused an important systemic decrease in NO and TNF-α levels. These findings are associated with the reduction of CE development. Conclusions: This is the first report demonstrating with interest the antihydatic and immunomodulatory effects of the Algerian EEP, suggesting its therapeutic potential for the hydatid disease treatment. |
format |
Article in Journal/Newspaper |
author |
Nahla Deghbar Dalila Mezioug Touri Kahina Yacine-Miloud Medjdoub Chafia Touil- Boukoffa |
author_facet |
Nahla Deghbar Dalila Mezioug Touri Kahina Yacine-Miloud Medjdoub Chafia Touil- Boukoffa |
author_sort |
Nahla Deghbar |
title |
Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract: In vitro and in vivo study |
title_short |
Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract: In vitro and in vivo study |
title_full |
Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract: In vitro and in vivo study |
title_fullStr |
Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract: In vitro and in vivo study |
title_full_unstemmed |
Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract: In vitro and in vivo study |
title_sort |
antihydatic and immunomodulatory effects of algerian propolis ethanolic extract: in vitro and in vivo study |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2019 |
url |
https://doi.org/10.4103/1995-7645.254936 https://doaj.org/article/07460338d8bb4301bb0b175d4b8b5e87 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 3, Pp 106-116 (2019) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=3;spage=106;epage=116;aulast=Deghbar https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.254936 https://doaj.org/article/07460338d8bb4301bb0b175d4b8b5e87 |
op_doi |
https://doi.org/10.4103/1995-7645.254936 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
12 |
container_issue |
3 |
container_start_page |
106 |
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1766339015969079296 |