Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties
Abstract For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus. However, in the past decades, progressive studi...
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ftdoajarticles:oai:doaj.org/article:07099c97f8054f29af6881849b2a1823 2023-05-15T15:04:38+02:00 Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties Marco Aurélio Sartim Danilo Luccas Menaldo Suely Vilela Sampaio 2018-12-01T00:00:00Z https://doi.org/10.1186/s40409-018-0178-3 https://doaj.org/article/07099c97f8054f29af6881849b2a1823 EN eng SciELO http://link.springer.com/article/10.1186/s40409-018-0178-3 https://doaj.org/toc/1678-9199 doi:10.1186/s40409-018-0178-3 1678-9199 https://doaj.org/article/07099c97f8054f29af6881849b2a1823 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-13 (2018) Crotalus durissus terrificus Crotoxin Innate immunity Adaptative immunity Inflammation Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2018 ftdoajarticles https://doi.org/10.1186/s40409-018-0178-3 2022-12-31T14:06:48Z Abstract For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus. However, in the past decades, progressive studies have led researchers to shift their focus on Crotoxin, opening novel perspectives and applications as a therapeutic approach. Although this toxin acts on a wide variety of biological events, the modulation of immune responses is considered as one of its most relevant behaviors. Therefore, the present review describes the scientific investigations on the capacity of Crotoxin to modulate anti-inflammatory and immunosuppressive responses, and its application as a medicinal immunopharmacological approach. In addition, this review will also discuss its mechanisms, involving cellular and molecular pathways, capable of improving pathological alterations related to immune-associated disorders. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 24 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Crotalus durissus terrificus Crotoxin Innate immunity Adaptative immunity Inflammation Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Crotalus durissus terrificus Crotoxin Innate immunity Adaptative immunity Inflammation Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Marco Aurélio Sartim Danilo Luccas Menaldo Suely Vilela Sampaio Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties |
topic_facet |
Crotalus durissus terrificus Crotoxin Innate immunity Adaptative immunity Inflammation Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus. However, in the past decades, progressive studies have led researchers to shift their focus on Crotoxin, opening novel perspectives and applications as a therapeutic approach. Although this toxin acts on a wide variety of biological events, the modulation of immune responses is considered as one of its most relevant behaviors. Therefore, the present review describes the scientific investigations on the capacity of Crotoxin to modulate anti-inflammatory and immunosuppressive responses, and its application as a medicinal immunopharmacological approach. In addition, this review will also discuss its mechanisms, involving cellular and molecular pathways, capable of improving pathological alterations related to immune-associated disorders. |
format |
Article in Journal/Newspaper |
author |
Marco Aurélio Sartim Danilo Luccas Menaldo Suely Vilela Sampaio |
author_facet |
Marco Aurélio Sartim Danilo Luccas Menaldo Suely Vilela Sampaio |
author_sort |
Marco Aurélio Sartim |
title |
Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties |
title_short |
Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties |
title_full |
Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties |
title_fullStr |
Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties |
title_full_unstemmed |
Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties |
title_sort |
immunotherapeutic potential of crotoxin: anti-inflammatory and immunosuppressive properties |
publisher |
SciELO |
publishDate |
2018 |
url |
https://doi.org/10.1186/s40409-018-0178-3 https://doaj.org/article/07099c97f8054f29af6881849b2a1823 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-13 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s40409-018-0178-3 https://doaj.org/toc/1678-9199 doi:10.1186/s40409-018-0178-3 1678-9199 https://doaj.org/article/07099c97f8054f29af6881849b2a1823 |
op_doi |
https://doi.org/10.1186/s40409-018-0178-3 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
24 |
container_issue |
1 |
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1766336365589430272 |