TGF-β1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Fabiane Vieira Berg Shehadeh, Rosiane Ribeiro dos Santos, Laiane Alzira Denski da Silva, Waldir Veríssimo da Silva Júnior, Rejane Ribas-Silva, Adriana Danmvolf Ribas, Thaís Gomes Verzignassi Silveira, Sueli Donizete Borelli, Sandra Mara Alessi Aristides
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2019
• Subjects: Cutaneous leishmaniasis; Genotyping; Gene polymorphisms; Cytokines; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0415-2017; https://doaj.org/article/069a47c78ec346f781faa623202860ab

Abstract INTRODUCTION: Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL). METHODS: Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay. RESULTS: G and C alleles of TGF- β1 (codon 25) were the most common in controls and patients, respectively. G/G was the most frequent genotype in controls, and G/C and C/C in patients. CONCLUSIONS: G/G genotype of codon 25 in TGF-β1 appeared to confer resistance, and G/C and C/C genotypes, susceptibility to TL in this population.