Association between Antibiotic Consumption and Resistance in Mink Production
Antibiotic consumption is considered to be a main driver of antibiotic resistant bacteria. Mink breeding follows a distinctive seasonal reproduction cycle, and all of the mink produced in the northern hemisphere are bred, born, and pelted around the same time of year. Some of the diseases are age-re...
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2022
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ftdoajarticles:oai:doaj.org/article:065e4040edd342a1ac16744a6a4cf308 2024-01-07T09:44:19+01:00 Association between Antibiotic Consumption and Resistance in Mink Production Nanett Kvist Nikolaisen Mette Fertner Desiree Corvera Kløve Lassen Chaza Nazih Chehabi Amir Atabak Ronaghinia Mariann Chriél Vibeke Frøkjær Jensen Lars Bogø Jensen Karl Pedersen Tina Struve 2022-07-01T00:00:00Z https://doi.org/10.3390/antibiotics11070927 https://doaj.org/article/065e4040edd342a1ac16744a6a4cf308 EN eng MDPI AG https://www.mdpi.com/2079-6382/11/7/927 https://doaj.org/toc/2079-6382 doi:10.3390/antibiotics11070927 2079-6382 https://doaj.org/article/065e4040edd342a1ac16744a6a4cf308 Antibiotics, Vol 11, Iss 7, p 927 (2022) antibiotic resistance antibiotic consumption Staphylococcus delphini Escherichia coli epidemiology Therapeutics. Pharmacology RM1-950 article 2022 ftdoajarticles https://doi.org/10.3390/antibiotics11070927 2023-12-10T01:43:24Z Antibiotic consumption is considered to be a main driver of antibiotic resistant bacteria. Mink breeding follows a distinctive seasonal reproduction cycle, and all of the mink produced in the northern hemisphere are bred, born, and pelted around the same time of year. Some of the diseases are age-related, which is reflected in the seasonal variation of antibiotic consumption. The seasonality makes mink a good model for the investigation of the association between antibiotic consumption and resistance. The objectives of this study were (1) to monitor the farm level of antibiotic resistance during one production cycle and (2) to assess the potential associations between antibiotic consumption and resistance. Twenty-four farms were included in this study (Denmark n = 20, Iceland n = 2, and The Netherlands n = 2), following a cohort of animals born in 2018. Staphylococcus delphini and Escherichia coli were isolated from samples of the carcasses and faeces and were collected randomly. The isolates were susceptibility tested and subsequently divided into the sensitive wildtype (WT) and the resistant non-wildtype (NWT) populations. The antibiotic consumption relative to the sampling periods was assessed as having a short-term or a long-term impact, i.e., in two explanatory factors. For both S. delphini and E. coli , a large between-farm variation of NWT profiles was detected. In the final multivariable, generalized linear mixed models, significant associations between NWT isolates and the consumption of specific antibiotics were found: the short-term use of tetracyclines in the growth period was associated with the occurrence of tetracycline NWT E. coli in the growth period (OR: 11.94 [1.78; 89.28]), and the long-term use of macrolide and tetracyclines was associated with the occurrence of erythromycin NWT S. delphini in the weaning period (OR: 18.2 [2.26; 321.36]) and tetracycline NWT S. delphini in the growth period (OR: 8.2 [1.27; 63.31]), respectively. Farms with zero consumption in the study years prior to ... Article in Journal/Newspaper Iceland Directory of Open Access Journals: DOAJ Articles Antibiotics 11 7 927 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
antibiotic resistance antibiotic consumption Staphylococcus delphini Escherichia coli epidemiology Therapeutics. Pharmacology RM1-950 |
spellingShingle |
antibiotic resistance antibiotic consumption Staphylococcus delphini Escherichia coli epidemiology Therapeutics. Pharmacology RM1-950 Nanett Kvist Nikolaisen Mette Fertner Desiree Corvera Kløve Lassen Chaza Nazih Chehabi Amir Atabak Ronaghinia Mariann Chriél Vibeke Frøkjær Jensen Lars Bogø Jensen Karl Pedersen Tina Struve Association between Antibiotic Consumption and Resistance in Mink Production |
topic_facet |
antibiotic resistance antibiotic consumption Staphylococcus delphini Escherichia coli epidemiology Therapeutics. Pharmacology RM1-950 |
description |
Antibiotic consumption is considered to be a main driver of antibiotic resistant bacteria. Mink breeding follows a distinctive seasonal reproduction cycle, and all of the mink produced in the northern hemisphere are bred, born, and pelted around the same time of year. Some of the diseases are age-related, which is reflected in the seasonal variation of antibiotic consumption. The seasonality makes mink a good model for the investigation of the association between antibiotic consumption and resistance. The objectives of this study were (1) to monitor the farm level of antibiotic resistance during one production cycle and (2) to assess the potential associations between antibiotic consumption and resistance. Twenty-four farms were included in this study (Denmark n = 20, Iceland n = 2, and The Netherlands n = 2), following a cohort of animals born in 2018. Staphylococcus delphini and Escherichia coli were isolated from samples of the carcasses and faeces and were collected randomly. The isolates were susceptibility tested and subsequently divided into the sensitive wildtype (WT) and the resistant non-wildtype (NWT) populations. The antibiotic consumption relative to the sampling periods was assessed as having a short-term or a long-term impact, i.e., in two explanatory factors. For both S. delphini and E. coli , a large between-farm variation of NWT profiles was detected. In the final multivariable, generalized linear mixed models, significant associations between NWT isolates and the consumption of specific antibiotics were found: the short-term use of tetracyclines in the growth period was associated with the occurrence of tetracycline NWT E. coli in the growth period (OR: 11.94 [1.78; 89.28]), and the long-term use of macrolide and tetracyclines was associated with the occurrence of erythromycin NWT S. delphini in the weaning period (OR: 18.2 [2.26; 321.36]) and tetracycline NWT S. delphini in the growth period (OR: 8.2 [1.27; 63.31]), respectively. Farms with zero consumption in the study years prior to ... |
format |
Article in Journal/Newspaper |
author |
Nanett Kvist Nikolaisen Mette Fertner Desiree Corvera Kløve Lassen Chaza Nazih Chehabi Amir Atabak Ronaghinia Mariann Chriél Vibeke Frøkjær Jensen Lars Bogø Jensen Karl Pedersen Tina Struve |
author_facet |
Nanett Kvist Nikolaisen Mette Fertner Desiree Corvera Kløve Lassen Chaza Nazih Chehabi Amir Atabak Ronaghinia Mariann Chriél Vibeke Frøkjær Jensen Lars Bogø Jensen Karl Pedersen Tina Struve |
author_sort |
Nanett Kvist Nikolaisen |
title |
Association between Antibiotic Consumption and Resistance in Mink Production |
title_short |
Association between Antibiotic Consumption and Resistance in Mink Production |
title_full |
Association between Antibiotic Consumption and Resistance in Mink Production |
title_fullStr |
Association between Antibiotic Consumption and Resistance in Mink Production |
title_full_unstemmed |
Association between Antibiotic Consumption and Resistance in Mink Production |
title_sort |
association between antibiotic consumption and resistance in mink production |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/antibiotics11070927 https://doaj.org/article/065e4040edd342a1ac16744a6a4cf308 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Antibiotics, Vol 11, Iss 7, p 927 (2022) |
op_relation |
https://www.mdpi.com/2079-6382/11/7/927 https://doaj.org/toc/2079-6382 doi:10.3390/antibiotics11070927 2079-6382 https://doaj.org/article/065e4040edd342a1ac16744a6a4cf308 |
op_doi |
https://doi.org/10.3390/antibiotics11070927 |
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Antibiotics |
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11 |
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7 |
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927 |
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