Malaria vaccines and their potential role in the elimination of malaria
Abstract Research on malaria vaccines is currently directed primarily towards the development of vaccines that prevent clinical malaria. Malaria elimination, now being considered seriously in some epidemiological situations, requires a different vaccine strategy, since success will depend on killing...
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ftdoajarticles:oai:doaj.org/article:05f109f6cb63468f9c184777ac03ba48 2023-05-15T15:07:23+02:00 Malaria vaccines and their potential role in the elimination of malaria Greenwood Brian M Targett Geoffrey A 2008-12-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-S1-S10 https://doaj.org/article/05f109f6cb63468f9c184777ac03ba48 EN eng BMC http://www.malariajournal.com/content/7/S1/S10 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-S1-S10 1475-2875 https://doaj.org/article/05f109f6cb63468f9c184777ac03ba48 Malaria Journal, Vol 7, Iss Suppl 1, p S10 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-S1-S10 2022-12-31T03:30:03Z Abstract Research on malaria vaccines is currently directed primarily towards the development of vaccines that prevent clinical malaria. Malaria elimination, now being considered seriously in some epidemiological situations, requires a different vaccine strategy, since success will depend on killing all parasites in the community in order to stop transmission completely. The feature of the life-cycles of human malarias that presents the greatest challenge to an elimination programme is the persistence of parasites as asymptomatic infections. These are an important source from which transmission to mosquitoes can occur. Consequently, an elimination strategy requires a community-based approach covering all individuals and not just those who are susceptible to clinical malaria. The progress that has been made in development of candidate malaria vaccines is reviewed. It is unlikely that many of these will have the efficacy required for complete elimination of parasites, though they may have an important role to play as part of future integrated control programmes. Vaccines for elimination must have a high level of efficacy in order to stop transmission to mosquitoes. This might be achieved with some pre-erythrocytic stage candidate vaccines or by targeting the sexual stages directly with transmission-blocking vaccines. An expanded malaria vaccine programme with such objectives is now a priority. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 S1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Greenwood Brian M Targett Geoffrey A Malaria vaccines and their potential role in the elimination of malaria |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Research on malaria vaccines is currently directed primarily towards the development of vaccines that prevent clinical malaria. Malaria elimination, now being considered seriously in some epidemiological situations, requires a different vaccine strategy, since success will depend on killing all parasites in the community in order to stop transmission completely. The feature of the life-cycles of human malarias that presents the greatest challenge to an elimination programme is the persistence of parasites as asymptomatic infections. These are an important source from which transmission to mosquitoes can occur. Consequently, an elimination strategy requires a community-based approach covering all individuals and not just those who are susceptible to clinical malaria. The progress that has been made in development of candidate malaria vaccines is reviewed. It is unlikely that many of these will have the efficacy required for complete elimination of parasites, though they may have an important role to play as part of future integrated control programmes. Vaccines for elimination must have a high level of efficacy in order to stop transmission to mosquitoes. This might be achieved with some pre-erythrocytic stage candidate vaccines or by targeting the sexual stages directly with transmission-blocking vaccines. An expanded malaria vaccine programme with such objectives is now a priority. |
format |
Article in Journal/Newspaper |
author |
Greenwood Brian M Targett Geoffrey A |
author_facet |
Greenwood Brian M Targett Geoffrey A |
author_sort |
Greenwood Brian M |
title |
Malaria vaccines and their potential role in the elimination of malaria |
title_short |
Malaria vaccines and their potential role in the elimination of malaria |
title_full |
Malaria vaccines and their potential role in the elimination of malaria |
title_fullStr |
Malaria vaccines and their potential role in the elimination of malaria |
title_full_unstemmed |
Malaria vaccines and their potential role in the elimination of malaria |
title_sort |
malaria vaccines and their potential role in the elimination of malaria |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-S1-S10 https://doaj.org/article/05f109f6cb63468f9c184777ac03ba48 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss Suppl 1, p S10 (2008) |
op_relation |
http://www.malariajournal.com/content/7/S1/S10 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-S1-S10 1475-2875 https://doaj.org/article/05f109f6cb63468f9c184777ac03ba48 |
op_doi |
https://doi.org/10.1186/1475-2875-7-S1-S10 |
container_title |
Malaria Journal |
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7 |
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S1 |
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1766338897528225792 |