Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children
Objective. In a recent study, we found that Greenlandic Inuit children had a more adverse metabolic profile than Danish children. Aerobic fitness and adiposity could only partly account for the differences. Therefore, we set out to evaluate and compare plasma leptin and adiponectin levels in Danish...
Published in: | International Journal of Circumpolar Health |
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Taylor & Francis Group
2013
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Online Access: | https://doi.org/10.3402/ijch.v72i0.21458 https://doaj.org/article/05ebc8ccc411481b94604f1e0f94341b |
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ftdoajarticles:oai:doaj.org/article:05ebc8ccc411481b94604f1e0f94341b 2023-05-15T15:13:55+02:00 Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children Thor Munch-Andersen Kaspar Sorensen Niels-Jacob Aachmann-Andersen Lise Aksglaede Anders Juul Jørn W. Helge 2013-08-01T00:00:00Z https://doi.org/10.3402/ijch.v72i0.21458 https://doaj.org/article/05ebc8ccc411481b94604f1e0f94341b EN eng Taylor & Francis Group www.circumpolarhealthjournal.net/index.php/ijch/article/download/21458/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.21458 2242-3982 https://doaj.org/article/05ebc8ccc411481b94604f1e0f94341b International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-7 (2013) leptin adiponectin children metabolic syndrome ethnic differences Inuit leptin/adiponectin ratio Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.3402/ijch.v72i0.21458 2022-12-31T13:33:49Z Objective. In a recent study, we found that Greenlandic Inuit children had a more adverse metabolic profile than Danish children. Aerobic fitness and adiposity could only partly account for the differences. Therefore, we set out to evaluate and compare plasma leptin and adiponectin levels in Danish and Inuit children. Methods. In total, 187 Inuit and 132 Danish children (5.7–17.1 years) had examinations of anthropometrics, body fat content, pubertal staging, fasting blood and aerobic fitness. Results. Plasma leptin was higher in Danish boys [3,774 (4,741–3,005)] [pg/mL unadjusted geometric mean (95% CI)] compared to both northern [2,076 (2,525–1,706)] (p<0.001) and southern (2,515 (3,137–2,016)) (p<0.001) living Inuit boys and higher in Danish girls [6,988 (8,353–5,847)] compared to southern living Inuit girls [4,910 (6,370–3,785)] (p=0.021) and tended to be higher compared to northern living Inuit girls [5,131 (6,444–4,085)] (p=0.052). Plasma adiponectin was higher for both Danish boys [22,359 (2,573–19,428)] [ng/mL unadjusted geometric mean (95% CI)] and girls [26,609 (28,994–24,420)] compared to southern living Inuit boys [15,306 (18,406–12,728)] and girls [18,864 (22,640–15,717)] (both p<0.001), respectively. All differences remained after adjustment for body fat percentage (BF%), aerobic fitness, age and puberty. The leptin/adiponectin ratio was higher in Danish boys and tended to be higher in Danish girls compared to northern living Inuit boys and girls, respectively. These differences were eliminated after adjustment for BF%, aerobic fitness, age and puberty. Conclusions. In contrast to our hypothesis, plasma leptin was higher in Danish children despite a more healthy metabolic profile compared to Inuit children. As expected, plasma adiponectin was lowest in Inuit children with the most adverse metabolic profile. Article in Journal/Newspaper Arctic Circumpolar Health greenlandic International Journal of Circumpolar Health inuit Directory of Open Access Journals: DOAJ Articles Arctic International Journal of Circumpolar Health 72 1 21458 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
leptin adiponectin children metabolic syndrome ethnic differences Inuit leptin/adiponectin ratio Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
leptin adiponectin children metabolic syndrome ethnic differences Inuit leptin/adiponectin ratio Arctic medicine. Tropical medicine RC955-962 Thor Munch-Andersen Kaspar Sorensen Niels-Jacob Aachmann-Andersen Lise Aksglaede Anders Juul Jørn W. Helge Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
topic_facet |
leptin adiponectin children metabolic syndrome ethnic differences Inuit leptin/adiponectin ratio Arctic medicine. Tropical medicine RC955-962 |
description |
Objective. In a recent study, we found that Greenlandic Inuit children had a more adverse metabolic profile than Danish children. Aerobic fitness and adiposity could only partly account for the differences. Therefore, we set out to evaluate and compare plasma leptin and adiponectin levels in Danish and Inuit children. Methods. In total, 187 Inuit and 132 Danish children (5.7–17.1 years) had examinations of anthropometrics, body fat content, pubertal staging, fasting blood and aerobic fitness. Results. Plasma leptin was higher in Danish boys [3,774 (4,741–3,005)] [pg/mL unadjusted geometric mean (95% CI)] compared to both northern [2,076 (2,525–1,706)] (p<0.001) and southern (2,515 (3,137–2,016)) (p<0.001) living Inuit boys and higher in Danish girls [6,988 (8,353–5,847)] compared to southern living Inuit girls [4,910 (6,370–3,785)] (p=0.021) and tended to be higher compared to northern living Inuit girls [5,131 (6,444–4,085)] (p=0.052). Plasma adiponectin was higher for both Danish boys [22,359 (2,573–19,428)] [ng/mL unadjusted geometric mean (95% CI)] and girls [26,609 (28,994–24,420)] compared to southern living Inuit boys [15,306 (18,406–12,728)] and girls [18,864 (22,640–15,717)] (both p<0.001), respectively. All differences remained after adjustment for body fat percentage (BF%), aerobic fitness, age and puberty. The leptin/adiponectin ratio was higher in Danish boys and tended to be higher in Danish girls compared to northern living Inuit boys and girls, respectively. These differences were eliminated after adjustment for BF%, aerobic fitness, age and puberty. Conclusions. In contrast to our hypothesis, plasma leptin was higher in Danish children despite a more healthy metabolic profile compared to Inuit children. As expected, plasma adiponectin was lowest in Inuit children with the most adverse metabolic profile. |
format |
Article in Journal/Newspaper |
author |
Thor Munch-Andersen Kaspar Sorensen Niels-Jacob Aachmann-Andersen Lise Aksglaede Anders Juul Jørn W. Helge |
author_facet |
Thor Munch-Andersen Kaspar Sorensen Niels-Jacob Aachmann-Andersen Lise Aksglaede Anders Juul Jørn W. Helge |
author_sort |
Thor Munch-Andersen |
title |
Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
title_short |
Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
title_full |
Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
title_fullStr |
Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
title_full_unstemmed |
Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
title_sort |
ethnic differences in leptin and adiponectin levels between greenlandic inuit and danish children |
publisher |
Taylor & Francis Group |
publishDate |
2013 |
url |
https://doi.org/10.3402/ijch.v72i0.21458 https://doaj.org/article/05ebc8ccc411481b94604f1e0f94341b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Circumpolar Health greenlandic International Journal of Circumpolar Health inuit |
genre_facet |
Arctic Circumpolar Health greenlandic International Journal of Circumpolar Health inuit |
op_source |
International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-7 (2013) |
op_relation |
www.circumpolarhealthjournal.net/index.php/ijch/article/download/21458/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.21458 2242-3982 https://doaj.org/article/05ebc8ccc411481b94604f1e0f94341b |
op_doi |
https://doi.org/10.3402/ijch.v72i0.21458 |
container_title |
International Journal of Circumpolar Health |
container_volume |
72 |
container_issue |
1 |
container_start_page |
21458 |
_version_ |
1766344421833441280 |