The first human epitope map of the alphaviral E1 and E2 proteins reveals a new E2 epitope with significant virus neutralizing activity.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Ann R Hunt, Shana Frederickson, Toshiaki Maruyama, John T Roehrig, Carol D Blair
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2010
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Nigg
• Online Access: https://doi.org/10.1371/journal.pntd.0000739; https://doaj.org/article/05da1765fd2245db852ae49bd17d2266

Venezuelan equine encephalitis virus (VEEV) is responsible for VEE epidemics that occur in South and Central America and the U.S. The VEEV envelope contains two glycoproteins E1 (mediates cell membrane fusion) and E2 (binds receptor and elicits virus neutralizing antibodies). Previously we construct...