Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam
Objective: To determine the prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam and to explore its underlying causes. Methods: A retrospective cohort study was conducted where data on socio-demographics, clinical characteristics and treatment outcomes of all tuber...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:05bfc15090084d0885c53d06561332ed 2023-05-15T15:09:49+02:00 Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam Liling Chaw Nurul Huda Jeludin Kyaw Thu 2023-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.368018 https://doaj.org/article/05bfc15090084d0885c53d06561332ed EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=1;spage=9;epage=15;aulast=Chaw https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.368018 https://doaj.org/article/05bfc15090084d0885c53d06561332ed Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 1, Pp 9-15 (2023) mycobacterium infections tuberculosis mortality brunei Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.4103/1995-7645.368018 2023-02-19T01:28:01Z Objective: To determine the prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam and to explore its underlying causes. Methods: A retrospective cohort study was conducted where data on socio-demographics, clinical characteristics and treatment outcomes of all tuberculosis patients registered at the National tuberculosis Coordinating Centre between 2013 and 2017 were collected. Overall tuberculosis mortality and the proportion of tuberculosis-related deaths were calculated. Logistic regression analysis was used to determine the risk factors of tuberculosis mortality when compared to those who are cured and/or completed tuberculosis treatment. Results: Of 1 107 tuberculosis cases, 99 died, giving an overall tuberculosis mortality rate of 8.9% (95% CI 7.4%-10.8%). Significant risk factors associated with tuberculosis mortality were age ⩾40 years (adjusted OR for 40-59 years was 3.89; 95% CI 1.13-1.69; adjusted OR for ⩾60 years was 22.3; 95% CI 7.27-91.9, using 20-39 years as reference), female sex (adjusted OR 1.74; 95% CI 1.09-2.79), having renal disease (adjusted OR 25.7; 95% CI 2.82-191.50) and having any cancers (adjusted OR 3.61; 95% CI 1.26-10.00). The majority (75.8%) of the recorded deaths were not related to tuberculosis. Conclusions: Tuberculosis patients who were older than 40 years, female, and having renal disease and any cancer will need close monitoring in their management program to prevent tuberculosis mortality. Clinicians should also focus on other non-tuberculosis aspects of the patient’s medical history. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 16 1 9 |
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Directory of Open Access Journals: DOAJ Articles |
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mycobacterium infections tuberculosis mortality brunei Arctic medicine. Tropical medicine RC955-962 |
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mycobacterium infections tuberculosis mortality brunei Arctic medicine. Tropical medicine RC955-962 Liling Chaw Nurul Huda Jeludin Kyaw Thu Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam |
topic_facet |
mycobacterium infections tuberculosis mortality brunei Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To determine the prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam and to explore its underlying causes. Methods: A retrospective cohort study was conducted where data on socio-demographics, clinical characteristics and treatment outcomes of all tuberculosis patients registered at the National tuberculosis Coordinating Centre between 2013 and 2017 were collected. Overall tuberculosis mortality and the proportion of tuberculosis-related deaths were calculated. Logistic regression analysis was used to determine the risk factors of tuberculosis mortality when compared to those who are cured and/or completed tuberculosis treatment. Results: Of 1 107 tuberculosis cases, 99 died, giving an overall tuberculosis mortality rate of 8.9% (95% CI 7.4%-10.8%). Significant risk factors associated with tuberculosis mortality were age ⩾40 years (adjusted OR for 40-59 years was 3.89; 95% CI 1.13-1.69; adjusted OR for ⩾60 years was 22.3; 95% CI 7.27-91.9, using 20-39 years as reference), female sex (adjusted OR 1.74; 95% CI 1.09-2.79), having renal disease (adjusted OR 25.7; 95% CI 2.82-191.50) and having any cancers (adjusted OR 3.61; 95% CI 1.26-10.00). The majority (75.8%) of the recorded deaths were not related to tuberculosis. Conclusions: Tuberculosis patients who were older than 40 years, female, and having renal disease and any cancer will need close monitoring in their management program to prevent tuberculosis mortality. Clinicians should also focus on other non-tuberculosis aspects of the patient’s medical history. |
format |
Article in Journal/Newspaper |
author |
Liling Chaw Nurul Huda Jeludin Kyaw Thu |
author_facet |
Liling Chaw Nurul Huda Jeludin Kyaw Thu |
author_sort |
Liling Chaw |
title |
Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam |
title_short |
Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam |
title_full |
Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam |
title_fullStr |
Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam |
title_full_unstemmed |
Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam |
title_sort |
prevalence and risk factors associated with tuberculosis mortality in brunei darussalam |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2023 |
url |
https://doi.org/10.4103/1995-7645.368018 https://doaj.org/article/05bfc15090084d0885c53d06561332ed |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 1, Pp 9-15 (2023) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=1;spage=9;epage=15;aulast=Chaw https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.368018 https://doaj.org/article/05bfc15090084d0885c53d06561332ed |
op_doi |
https://doi.org/10.4103/1995-7645.368018 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
16 |
container_issue |
1 |
container_start_page |
9 |
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1766340928896761856 |