Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study.
BACKGROUND: Dengue hemorrhagic fever (DHF) is a severe form of dengue, characterized by bleeding and plasma leakage. A number of DHF risk factors had been suggested. However, these risk factors may not be generalized to all populations and epidemics for screening and clinical management of patients...
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Online Access: | https://doi.org/10.1371/journal.pntd.0001641 https://doaj.org/article/05b4b6c7e6c4415fb85df3f83ea5f5dc |
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ftdoajarticles:oai:doaj.org/article:05b4b6c7e6c4415fb85df3f83ea5f5dc 2023-05-15T15:18:35+02:00 Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. Junxiong Pang Agus Salim Vernon J Lee Martin L Hibberd Kee Seng Chia Yee Sin Leo David C Lye 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001641 https://doaj.org/article/05b4b6c7e6c4415fb85df3f83ea5f5dc EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3341340?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001641 https://doaj.org/article/05b4b6c7e6c4415fb85df3f83ea5f5dc PLoS Neglected Tropical Diseases, Vol 6, Iss 5, p e1641 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001641 2022-12-31T03:57:40Z BACKGROUND: Dengue hemorrhagic fever (DHF) is a severe form of dengue, characterized by bleeding and plasma leakage. A number of DHF risk factors had been suggested. However, these risk factors may not be generalized to all populations and epidemics for screening and clinical management of patients at risk of developing DHF. This study explored demographic and comorbidity risk factors for DHF in adult dengue epidemics in Singapore in year 2006 (predominantly serotype 1) and in year 2007-2008 (predominantly serotype 2). METHODS: A retrospective case-control study was conducted with 149 DHF and 326 dengue fever (DF) patients from year 2006, and 669 DHF and 1,141 DF patients from year 2007-2008. Demographic and reported comorbidity data were collected from patients previously. We performed multivariate logistic regression to assess the association between DHF and demographic and co-morbidities for year 2006 and year 2007-2008, respectively. RESULTS: Only Chinese (adjusted odds ratio [AOR] = 1.90; 95% confidence interval [CI]: 1.01-3.56) was independently associated with DHF in year 2006. In contrast, age groups of 30-39 years (AOR = 1.41; 95% CI:1.09-1.81), 40-49 years (AOR = 1.34; 95% CI:1.09-1.81), female (AOR = 1.57; 95% CI:1.28-1.94), Chinese (AOR = 1.67; 95% CI:1.24-2.24), diabetes (AOR = 1.78; 95% CI:1.06-2.97), and diabetes with hypertension (AOR = 2.16; 95%CI:1.18-3.96) were independently associated with DHF in year 2007-2008. Hypertension was proposed to have effect modification on the risk of DHF outcome in dengue patients with diabetes. Chinese who had diabetes with hypertension had 2.1 (95% CI:1.07-4.12) times higher risk of DHF compared with Chinese who had no diabetes and no hypertension. CONCLUSIONS: Adult dengue patients in Singapore who were 30-49 years, Chinese, female, had diabetes or diabetes with hypertension were at greater risk of developing DHF during epidemic of predominantly serotype 2. These risk factors can be used to guide triaging of patients who require closer clinical monitoring and ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 5 e1641 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Junxiong Pang Agus Salim Vernon J Lee Martin L Hibberd Kee Seng Chia Yee Sin Leo David C Lye Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Dengue hemorrhagic fever (DHF) is a severe form of dengue, characterized by bleeding and plasma leakage. A number of DHF risk factors had been suggested. However, these risk factors may not be generalized to all populations and epidemics for screening and clinical management of patients at risk of developing DHF. This study explored demographic and comorbidity risk factors for DHF in adult dengue epidemics in Singapore in year 2006 (predominantly serotype 1) and in year 2007-2008 (predominantly serotype 2). METHODS: A retrospective case-control study was conducted with 149 DHF and 326 dengue fever (DF) patients from year 2006, and 669 DHF and 1,141 DF patients from year 2007-2008. Demographic and reported comorbidity data were collected from patients previously. We performed multivariate logistic regression to assess the association between DHF and demographic and co-morbidities for year 2006 and year 2007-2008, respectively. RESULTS: Only Chinese (adjusted odds ratio [AOR] = 1.90; 95% confidence interval [CI]: 1.01-3.56) was independently associated with DHF in year 2006. In contrast, age groups of 30-39 years (AOR = 1.41; 95% CI:1.09-1.81), 40-49 years (AOR = 1.34; 95% CI:1.09-1.81), female (AOR = 1.57; 95% CI:1.28-1.94), Chinese (AOR = 1.67; 95% CI:1.24-2.24), diabetes (AOR = 1.78; 95% CI:1.06-2.97), and diabetes with hypertension (AOR = 2.16; 95%CI:1.18-3.96) were independently associated with DHF in year 2007-2008. Hypertension was proposed to have effect modification on the risk of DHF outcome in dengue patients with diabetes. Chinese who had diabetes with hypertension had 2.1 (95% CI:1.07-4.12) times higher risk of DHF compared with Chinese who had no diabetes and no hypertension. CONCLUSIONS: Adult dengue patients in Singapore who were 30-49 years, Chinese, female, had diabetes or diabetes with hypertension were at greater risk of developing DHF during epidemic of predominantly serotype 2. These risk factors can be used to guide triaging of patients who require closer clinical monitoring and ... |
format |
Article in Journal/Newspaper |
author |
Junxiong Pang Agus Salim Vernon J Lee Martin L Hibberd Kee Seng Chia Yee Sin Leo David C Lye |
author_facet |
Junxiong Pang Agus Salim Vernon J Lee Martin L Hibberd Kee Seng Chia Yee Sin Leo David C Lye |
author_sort |
Junxiong Pang |
title |
Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. |
title_short |
Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. |
title_full |
Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. |
title_fullStr |
Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. |
title_full_unstemmed |
Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. |
title_sort |
diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001641 https://doaj.org/article/05b4b6c7e6c4415fb85df3f83ea5f5dc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 5, p e1641 (2012) |
op_relation |
http://europepmc.org/articles/PMC3341340?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001641 https://doaj.org/article/05b4b6c7e6c4415fb85df3f83ea5f5dc |
op_doi |
https://doi.org/10.1371/journal.pntd.0001641 |
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PLoS Neglected Tropical Diseases |
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6 |
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5 |
container_start_page |
e1641 |
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1766348783108489216 |