Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot
The efficacy of intraperitoneal injection of an oil-based bivalent autogenous vaccine and the commercial vaccine AlphaJect 3000 (Pharmaq AS) to prevent atypical furunculosis and vibriosis in turbot was analyzed. The effect of both vaccines on health parameters and survival of fish after challenge wi...
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MDPI AG
2021
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Online Access: | https://doi.org/10.3390/vaccines9080906 https://doaj.org/article/0572142a4f82451dbfb44d930eac02fb |
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ftdoajarticles:oai:doaj.org/article:0572142a4f82451dbfb44d930eac02fb 2023-05-15T18:40:58+02:00 Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot Yolanda Torres-Corral Albert Girons Oscar González-Barreiro Rafael Seoane Ana Riaza Ysabel Santos 2021-08-01T00:00:00Z https://doi.org/10.3390/vaccines9080906 https://doaj.org/article/0572142a4f82451dbfb44d930eac02fb EN eng MDPI AG https://www.mdpi.com/2076-393X/9/8/906 https://doaj.org/toc/2076-393X doi:10.3390/vaccines9080906 2076-393X https://doaj.org/article/0572142a4f82451dbfb44d930eac02fb Vaccines, Vol 9, Iss 906, p 906 (2021) atypical furunculosis vibriosis autogenous vaccine turbot adjuvants Medicine R article 2021 ftdoajarticles https://doi.org/10.3390/vaccines9080906 2022-12-30T19:56:19Z The efficacy of intraperitoneal injection of an oil-based bivalent autogenous vaccine and the commercial vaccine AlphaJect 3000 (Pharmaq AS) to prevent atypical furunculosis and vibriosis in turbot was analyzed. The effect of both vaccines on health parameters and survival of fish after challenge with V. anguillarum and A. salmonicida subsp. achromogenes was tested. The autogenous vaccine conferred high levels of protection and long-lasting immunity against both pathogens with a single dose. However, severe side effects were observed in turbot injected with this autovaccine and minor negative effects with the AlphaJect 3000 vaccine and the adjuvant Montanide or Eolane. All vaccinated fish showed remarkable antibody agglutination titers, higher than those of control fish, which were maintained 160 d after vaccination. In conclusion, the autogenous bivalent vaccine induces long-lasting protection against atypical furunculosis and vibriosis in turbot, after administration of a single dose, at the cost of high side effects in fish. Therefore, the development of new vaccines should focus on autovaccines and the use of liquid paraffin adjuvants that increase protection with reduced or no side effects. Article in Journal/Newspaper Turbot Directory of Open Access Journals: DOAJ Articles Vaccines 9 8 906 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
atypical furunculosis vibriosis autogenous vaccine turbot adjuvants Medicine R |
spellingShingle |
atypical furunculosis vibriosis autogenous vaccine turbot adjuvants Medicine R Yolanda Torres-Corral Albert Girons Oscar González-Barreiro Rafael Seoane Ana Riaza Ysabel Santos Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
topic_facet |
atypical furunculosis vibriosis autogenous vaccine turbot adjuvants Medicine R |
description |
The efficacy of intraperitoneal injection of an oil-based bivalent autogenous vaccine and the commercial vaccine AlphaJect 3000 (Pharmaq AS) to prevent atypical furunculosis and vibriosis in turbot was analyzed. The effect of both vaccines on health parameters and survival of fish after challenge with V. anguillarum and A. salmonicida subsp. achromogenes was tested. The autogenous vaccine conferred high levels of protection and long-lasting immunity against both pathogens with a single dose. However, severe side effects were observed in turbot injected with this autovaccine and minor negative effects with the AlphaJect 3000 vaccine and the adjuvant Montanide or Eolane. All vaccinated fish showed remarkable antibody agglutination titers, higher than those of control fish, which were maintained 160 d after vaccination. In conclusion, the autogenous bivalent vaccine induces long-lasting protection against atypical furunculosis and vibriosis in turbot, after administration of a single dose, at the cost of high side effects in fish. Therefore, the development of new vaccines should focus on autovaccines and the use of liquid paraffin adjuvants that increase protection with reduced or no side effects. |
format |
Article in Journal/Newspaper |
author |
Yolanda Torres-Corral Albert Girons Oscar González-Barreiro Rafael Seoane Ana Riaza Ysabel Santos |
author_facet |
Yolanda Torres-Corral Albert Girons Oscar González-Barreiro Rafael Seoane Ana Riaza Ysabel Santos |
author_sort |
Yolanda Torres-Corral |
title |
Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
title_short |
Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
title_full |
Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
title_fullStr |
Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
title_full_unstemmed |
Effect of Bivalent Vaccines against Vibrio anguillarum and Aeromonas salmonicida Subspecie achromogenes on Health and Survival of Turbot |
title_sort |
effect of bivalent vaccines against vibrio anguillarum and aeromonas salmonicida subspecie achromogenes on health and survival of turbot |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doi.org/10.3390/vaccines9080906 https://doaj.org/article/0572142a4f82451dbfb44d930eac02fb |
genre |
Turbot |
genre_facet |
Turbot |
op_source |
Vaccines, Vol 9, Iss 906, p 906 (2021) |
op_relation |
https://www.mdpi.com/2076-393X/9/8/906 https://doaj.org/toc/2076-393X doi:10.3390/vaccines9080906 2076-393X https://doaj.org/article/0572142a4f82451dbfb44d930eac02fb |
op_doi |
https://doi.org/10.3390/vaccines9080906 |
container_title |
Vaccines |
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906 |
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