A project to validate the GLU test for preterm birth prediction in First Nations women
The protocol described in the present article aims to validate the GLU test, a test of mid-pregnancy vaginal microbiome, for PTB risk prediction in pregnant First Nations women. Preterm birth (PTB; birth before 37 completed weeks gestation) is associated with a higher risk of adverse neonatal outcom...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
CSIRO Publishing
2022
|
Subjects: | |
Online Access: | https://doaj.org/article/055cab605cb74c918cd65544e2c436d1 |
id |
ftdoajarticles:oai:doaj.org/article:055cab605cb74c918cd65544e2c436d1 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:055cab605cb74c918cd65544e2c436d1 2023-05-15T16:14:26+02:00 A project to validate the GLU test for preterm birth prediction in First Nations women Matthew S. Payne John P. Newnham Jane C. Thorn Lindi Masson Gilda Tachedjian Sarah Holder Agatha Kujawa Martin Lee Dorota A. Doherty Margaret Peel Holger W. Unger Kiarna Brown 2022-01-01T00:00:00Z https://doaj.org/article/055cab605cb74c918cd65544e2c436d1 EN eng CSIRO Publishing https://www.publish.csiro.au/ma/pdf/MA22032 https://doaj.org/toc/1324-4272 https://doaj.org/toc/2201-9189 1324-4272 2201-9189 https://doaj.org/article/055cab605cb74c918cd65544e2c436d1 Microbiology Australia, Vol 43, Iss 3, Pp 130-134 (2022) Australian First Nations diagnostic test genotype microbiome pregnancy preterm labour Microbiology QR1-502 article 2022 ftdoajarticles 2022-12-30T20:52:45Z The protocol described in the present article aims to validate the GLU test, a test of mid-pregnancy vaginal microbiome, for PTB risk prediction in pregnant First Nations women. Preterm birth (PTB; birth before 37 completed weeks gestation) is associated with a higher risk of adverse neonatal outcomes. First Nations communities are affected by increasing PTB rates, highest in remote communities, reaching 23%. Being able to predict women at high risk of PTB is one of the greatest challenges of our time. No reliable clinical predictors of PTB risk currently exist, beyond a previous history. Spontaneous PTB (sPTB) is highly associated with microbial infection. Recently, a Western Australian research team developed an innovative mid-pregnancy vaginal microbial DNA test, the ‘Gardnerella, Lactobacillus, Ureaplasma’ (GLU) test, capable of predicting up to 45% of sPTB cases. However, this test has only been validated in predominantly Caucasian pregnant women. The protocol described aims to validate the GLU test in pregnant First Nations women and where applicable, make modifications to this test to improve sensitivity and specificity within this population. Article in Journal/Newspaper First Nations Directory of Open Access Journals: DOAJ Articles |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Australian First Nations diagnostic test genotype microbiome pregnancy preterm labour Microbiology QR1-502 |
spellingShingle |
Australian First Nations diagnostic test genotype microbiome pregnancy preterm labour Microbiology QR1-502 Matthew S. Payne John P. Newnham Jane C. Thorn Lindi Masson Gilda Tachedjian Sarah Holder Agatha Kujawa Martin Lee Dorota A. Doherty Margaret Peel Holger W. Unger Kiarna Brown A project to validate the GLU test for preterm birth prediction in First Nations women |
topic_facet |
Australian First Nations diagnostic test genotype microbiome pregnancy preterm labour Microbiology QR1-502 |
description |
The protocol described in the present article aims to validate the GLU test, a test of mid-pregnancy vaginal microbiome, for PTB risk prediction in pregnant First Nations women. Preterm birth (PTB; birth before 37 completed weeks gestation) is associated with a higher risk of adverse neonatal outcomes. First Nations communities are affected by increasing PTB rates, highest in remote communities, reaching 23%. Being able to predict women at high risk of PTB is one of the greatest challenges of our time. No reliable clinical predictors of PTB risk currently exist, beyond a previous history. Spontaneous PTB (sPTB) is highly associated with microbial infection. Recently, a Western Australian research team developed an innovative mid-pregnancy vaginal microbial DNA test, the ‘Gardnerella, Lactobacillus, Ureaplasma’ (GLU) test, capable of predicting up to 45% of sPTB cases. However, this test has only been validated in predominantly Caucasian pregnant women. The protocol described aims to validate the GLU test in pregnant First Nations women and where applicable, make modifications to this test to improve sensitivity and specificity within this population. |
format |
Article in Journal/Newspaper |
author |
Matthew S. Payne John P. Newnham Jane C. Thorn Lindi Masson Gilda Tachedjian Sarah Holder Agatha Kujawa Martin Lee Dorota A. Doherty Margaret Peel Holger W. Unger Kiarna Brown |
author_facet |
Matthew S. Payne John P. Newnham Jane C. Thorn Lindi Masson Gilda Tachedjian Sarah Holder Agatha Kujawa Martin Lee Dorota A. Doherty Margaret Peel Holger W. Unger Kiarna Brown |
author_sort |
Matthew S. Payne |
title |
A project to validate the GLU test for preterm birth prediction in First Nations women |
title_short |
A project to validate the GLU test for preterm birth prediction in First Nations women |
title_full |
A project to validate the GLU test for preterm birth prediction in First Nations women |
title_fullStr |
A project to validate the GLU test for preterm birth prediction in First Nations women |
title_full_unstemmed |
A project to validate the GLU test for preterm birth prediction in First Nations women |
title_sort |
project to validate the glu test for preterm birth prediction in first nations women |
publisher |
CSIRO Publishing |
publishDate |
2022 |
url |
https://doaj.org/article/055cab605cb74c918cd65544e2c436d1 |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Microbiology Australia, Vol 43, Iss 3, Pp 130-134 (2022) |
op_relation |
https://www.publish.csiro.au/ma/pdf/MA22032 https://doaj.org/toc/1324-4272 https://doaj.org/toc/2201-9189 1324-4272 2201-9189 https://doaj.org/article/055cab605cb74c918cd65544e2c436d1 |
_version_ |
1766000240722182144 |