The magnitude of syphilis: from prevalence to vertical transmission
ABSTRACT Introduction: In 2013, the World Health Organization (WHO) reported that 1.9 million pregnant women were infected with syphilis worldwide, of which 66.5% had adverse fetal effects in cases of untreated syphilis. Congenital syphilis contributes significantly to infant mortality, accounting f...
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ftdoajarticles:oai:doaj.org/article:05595d0ef9774deab2f9fb3be5c73125 2024-09-09T19:27:31+00:00 The magnitude of syphilis: from prevalence to vertical transmission Luciane Rodrigues Pedreira de Cerqueira Denise L. M. Monteiro Stella R. Taquette Nádia C. P. Rodrigues Alexandre J. B. Trajano Flavio Monteiro de Souza Bianca De Melo Araújo 2017-12-01T00:00:00Z https://doi.org/10.1590/s1678-9946201759078 https://doaj.org/article/05595d0ef9774deab2f9fb3be5c73125 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000246&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201759078 https://doaj.org/article/05595d0ef9774deab2f9fb3be5c73125 Revista do Instituto de Medicina Tropical de São Paulo, Vol 59, Iss 0 (2017) Syphilis Gestation Congenital syphilis Prevalence VDRL Treponemal tests Treponema pallidum Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1590/s1678-9946201759078 2024-08-05T17:49:31Z ABSTRACT Introduction: In 2013, the World Health Organization (WHO) reported that 1.9 million pregnant women were infected with syphilis worldwide, of which 66.5% had adverse fetal effects in cases of untreated syphilis. Congenital syphilis contributes significantly to infant mortality, accounting for 305,000 perinatal deaths worldwide annually. Aim: To estimate the prevalence of syphilis in parturients, the incidence of congenital syphilis and the vertical transmission rate. Material and methods: a cross-sectional study with data collected from 2041 parturients who had undergone treatment between 2012 and 2014 in the maternity section of the Pedro Ernesto Hospital of the State University of Rio de Janeiro, in the metropolitan area of Rio de Janeiro. The inclusion criterion was positive VDRL and treponemal test in a hospital environment. Results: the prevalence of syphilis in pregnant women was 4.1% in 2012, 3.1% in 2013 and 5% in 2014, with official reporting of 15.6%, 25.0% and 48.1%, respectively. The incidence of congenital syphilis (CS) was 22/1,000 in live births (LB) in 2012; 17/1,000 LB in 2013 and 44.8/1,000 LB in 2014. CS underreporting during the period was 6.7%. Vertical transmission occurred in 65.8% of infants from infected mothers. It was concluded that, in 34.6% of the CS cases, maternal VDRL titers were = 1/4. Conclusion: Results demonstrate the magnitude of the disease, fragility of the reporting system in the assessment of the actual prevalence, impact on perinatal outcomes, and they are a warning about the real situation of syphilis, which is still underestimated in the State. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 59 0 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Syphilis Gestation Congenital syphilis Prevalence VDRL Treponemal tests Treponema pallidum Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Syphilis Gestation Congenital syphilis Prevalence VDRL Treponemal tests Treponema pallidum Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Luciane Rodrigues Pedreira de Cerqueira Denise L. M. Monteiro Stella R. Taquette Nádia C. P. Rodrigues Alexandre J. B. Trajano Flavio Monteiro de Souza Bianca De Melo Araújo The magnitude of syphilis: from prevalence to vertical transmission |
topic_facet |
Syphilis Gestation Congenital syphilis Prevalence VDRL Treponemal tests Treponema pallidum Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT Introduction: In 2013, the World Health Organization (WHO) reported that 1.9 million pregnant women were infected with syphilis worldwide, of which 66.5% had adverse fetal effects in cases of untreated syphilis. Congenital syphilis contributes significantly to infant mortality, accounting for 305,000 perinatal deaths worldwide annually. Aim: To estimate the prevalence of syphilis in parturients, the incidence of congenital syphilis and the vertical transmission rate. Material and methods: a cross-sectional study with data collected from 2041 parturients who had undergone treatment between 2012 and 2014 in the maternity section of the Pedro Ernesto Hospital of the State University of Rio de Janeiro, in the metropolitan area of Rio de Janeiro. The inclusion criterion was positive VDRL and treponemal test in a hospital environment. Results: the prevalence of syphilis in pregnant women was 4.1% in 2012, 3.1% in 2013 and 5% in 2014, with official reporting of 15.6%, 25.0% and 48.1%, respectively. The incidence of congenital syphilis (CS) was 22/1,000 in live births (LB) in 2012; 17/1,000 LB in 2013 and 44.8/1,000 LB in 2014. CS underreporting during the period was 6.7%. Vertical transmission occurred in 65.8% of infants from infected mothers. It was concluded that, in 34.6% of the CS cases, maternal VDRL titers were = 1/4. Conclusion: Results demonstrate the magnitude of the disease, fragility of the reporting system in the assessment of the actual prevalence, impact on perinatal outcomes, and they are a warning about the real situation of syphilis, which is still underestimated in the State. |
format |
Article in Journal/Newspaper |
author |
Luciane Rodrigues Pedreira de Cerqueira Denise L. M. Monteiro Stella R. Taquette Nádia C. P. Rodrigues Alexandre J. B. Trajano Flavio Monteiro de Souza Bianca De Melo Araújo |
author_facet |
Luciane Rodrigues Pedreira de Cerqueira Denise L. M. Monteiro Stella R. Taquette Nádia C. P. Rodrigues Alexandre J. B. Trajano Flavio Monteiro de Souza Bianca De Melo Araújo |
author_sort |
Luciane Rodrigues Pedreira de Cerqueira |
title |
The magnitude of syphilis: from prevalence to vertical transmission |
title_short |
The magnitude of syphilis: from prevalence to vertical transmission |
title_full |
The magnitude of syphilis: from prevalence to vertical transmission |
title_fullStr |
The magnitude of syphilis: from prevalence to vertical transmission |
title_full_unstemmed |
The magnitude of syphilis: from prevalence to vertical transmission |
title_sort |
magnitude of syphilis: from prevalence to vertical transmission |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2017 |
url |
https://doi.org/10.1590/s1678-9946201759078 https://doaj.org/article/05595d0ef9774deab2f9fb3be5c73125 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 59, Iss 0 (2017) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000246&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201759078 https://doaj.org/article/05595d0ef9774deab2f9fb3be5c73125 |
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https://doi.org/10.1590/s1678-9946201759078 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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59 |
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