One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border.
BACKGROUND:Chagas disease (Trypanosoma cruzi infection) is the leading cause of non-ischemic dilated cardiomyopathy in Latin America. Texas, particularly the southern region, has compounding factors that could contribute to T. cruzi transmission; however, epidemiologic studies are lacking. The aim o...
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ftdoajarticles:oai:doaj.org/article:053c4156cc1946c2b918c19a2e43df72 2023-05-15T15:08:39+02:00 One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border. Melissa N Garcia Sarah O'Day Susan Fisher-Hoch Rodion Gorchakov Ramiro Patino Teresa P Feria Arroyo Susan T Laing Job E Lopez Alexandra Ingber Kathryn M Jones Kristy O Murray 2016-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005074 https://doaj.org/article/053c4156cc1946c2b918c19a2e43df72 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5104435?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005074 https://doaj.org/article/053c4156cc1946c2b918c19a2e43df72 PLoS Neglected Tropical Diseases, Vol 10, Iss 11, p e0005074 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005074 2022-12-31T00:49:32Z BACKGROUND:Chagas disease (Trypanosoma cruzi infection) is the leading cause of non-ischemic dilated cardiomyopathy in Latin America. Texas, particularly the southern region, has compounding factors that could contribute to T. cruzi transmission; however, epidemiologic studies are lacking. The aim of this study was to ascertain the prevalence of T. cruzi in three different mammalian species (coyotes, stray domestic dogs, and humans) and vectors (Triatoma species) to understand the burden of Chagas disease among sylvatic, peridomestic, and domestic cycles. METHODOLOGY/PRINCIPAL FINDINGS:To determine prevalence of infection, we tested sera from coyotes, stray domestic dogs housed in public shelters, and residents participating in related research studies and found 8%, 3.8%, and 0.36% positive for T. cruzi, respectively. PCR was used to determine the prevalence of T. cruzi DNA in vectors collected in peridomestic locations in the region, with 56.5% testing positive for the parasite, further confirming risk of transmission in the region. CONCLUSIONS/SIGNIFICANCE:Our findings contribute to the growing body of evidence for autochthonous Chagas disease transmission in south Texas. Considering this region has a population of 1.3 million, and up to 30% of T. cruzi infected individuals developing severe cardiac disease, it is imperative that we identify high risk groups for surveillance and treatment purposes. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 11 e0005074 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Melissa N Garcia Sarah O'Day Susan Fisher-Hoch Rodion Gorchakov Ramiro Patino Teresa P Feria Arroyo Susan T Laing Job E Lopez Alexandra Ingber Kathryn M Jones Kristy O Murray One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Chagas disease (Trypanosoma cruzi infection) is the leading cause of non-ischemic dilated cardiomyopathy in Latin America. Texas, particularly the southern region, has compounding factors that could contribute to T. cruzi transmission; however, epidemiologic studies are lacking. The aim of this study was to ascertain the prevalence of T. cruzi in three different mammalian species (coyotes, stray domestic dogs, and humans) and vectors (Triatoma species) to understand the burden of Chagas disease among sylvatic, peridomestic, and domestic cycles. METHODOLOGY/PRINCIPAL FINDINGS:To determine prevalence of infection, we tested sera from coyotes, stray domestic dogs housed in public shelters, and residents participating in related research studies and found 8%, 3.8%, and 0.36% positive for T. cruzi, respectively. PCR was used to determine the prevalence of T. cruzi DNA in vectors collected in peridomestic locations in the region, with 56.5% testing positive for the parasite, further confirming risk of transmission in the region. CONCLUSIONS/SIGNIFICANCE:Our findings contribute to the growing body of evidence for autochthonous Chagas disease transmission in south Texas. Considering this region has a population of 1.3 million, and up to 30% of T. cruzi infected individuals developing severe cardiac disease, it is imperative that we identify high risk groups for surveillance and treatment purposes. |
format |
Article in Journal/Newspaper |
author |
Melissa N Garcia Sarah O'Day Susan Fisher-Hoch Rodion Gorchakov Ramiro Patino Teresa P Feria Arroyo Susan T Laing Job E Lopez Alexandra Ingber Kathryn M Jones Kristy O Murray |
author_facet |
Melissa N Garcia Sarah O'Day Susan Fisher-Hoch Rodion Gorchakov Ramiro Patino Teresa P Feria Arroyo Susan T Laing Job E Lopez Alexandra Ingber Kathryn M Jones Kristy O Murray |
author_sort |
Melissa N Garcia |
title |
One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border. |
title_short |
One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border. |
title_full |
One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border. |
title_fullStr |
One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border. |
title_full_unstemmed |
One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border. |
title_sort |
one health interactions of chagas disease vectors, canid hosts, and human residents along the texas-mexico border. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0005074 https://doaj.org/article/053c4156cc1946c2b918c19a2e43df72 |
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Arctic |
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Arctic |
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Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 11, p e0005074 (2016) |
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http://europepmc.org/articles/PMC5104435?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005074 https://doaj.org/article/053c4156cc1946c2b918c19a2e43df72 |
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https://doi.org/10.1371/journal.pntd.0005074 |
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PLOS Neglected Tropical Diseases |
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11 |
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e0005074 |
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